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  • Douglas McFadden

Poxviruses and the evolution of host range and virulence

Haller, S. L., Peng, C., McFadden, G. & Rothenburg, S., Jan 2014, In : Infection, Genetics and Evolution. 21, p. 15-40 26 p.

Research output: Contribution to journalReview article

83 Scopus citations

Poxvirus oncolytic virotherapy

Torres-Domínguez, L. E. & McFadden, G., Jun 3 2019, In : Expert Opinion on Biological Therapy. 19, 6, p. 561-573 13 p.

Research output: Contribution to journalReview article

5 Scopus citations

Production of myxoma virus gateway entry and expression libraries and validation of viral protein expression

Smallwood, S. E., Rahman, M. M., Werden, S. J., Martino, M. F. & McFadden, G., 2011, In : Current Protocols in Microbiology. SUPPL.21

Research output: Contribution to journalArticle

2 Scopus citations

Quantifying Antibody Responses Induced by Antigen-Agnostic Immunotherapies

van Vloten, J. P., Klafuric, E. M., Karimi, K., McFadden, G., Petrik, J. J., Wootton, S. K. & Bridle, B. W., Sep 13 2019, In : Molecular Therapy - Methods and Clinical Development. 14, p. 189-196 8 p.

Research output: Contribution to journalArticle

Open Access

Quantifying Antigen-Specific T Cell Responses When Using Antigen-Agnostic Immunotherapies

van Vloten, J. P., Santry, L. A., McAusland, T. M., Karimi, K., McFadden, D., Petrik, J. J., Wootton, S. K. & Bridle, B. W., Jun 14 2019, In : Molecular Therapy - Methods and Clinical Development. 13, p. 154-166 13 p.

Research output: Contribution to journalArticle

1 Scopus citations
6 Scopus citations

Resistance to Oncolytic Myxoma Virus Therapy in Nf1-/-/Trp53-/- Syngeneic Mouse Glioma Models Is Independent of Anti-Viral Type-I Interferon

Zemp, F. J., McKenzie, B. A., Lun, X., Maxwell, L., Reilly, K. M., McFadden, G., Yong, V. W. & Forsyth, P. A., Jun 6 2013, In : PloS one. 8, 6, e65801.

Research output: Contribution to journalArticle

10 Scopus citations

Scalable collaborative infrastructure for a learning healthcare system (SCILHS): Architecture

Mandl, K. D., Kohane, I. S., McFadden, D., Weber, G. M., Natter, M., Mandel, J., Schneeweiss, S., Weiler, S., Klann, J. G., Bickel, J., Adams, W. G., Ge, Y., Zhou, X., Perkins, J., Marsolo, K., Berns tam, E., Showalter, J., Quarshie, A., Ofili, E., Hripcsak, G. & 1 others, Murphy, S. N., 2014, In : Journal of the American Medical Informatics Association. 21, 4, p. 615-620 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Selective Purging of Human Multiple Myeloma Cells from Autologous Stem Cell Transplantation Grafts using Oncolytic Myxoma Virus

Bartee, E., Chan, W. M., Moreb, J. S., Cogle, C. R. & McFadden, G., Oct 2012, In : Biology of Blood and Marrow Transplantation. 18, 10, p. 1540-1551 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Serpins: Development for therapeutic applications

Lucas, A., Yaron, J. R., Zhang, L., Macaulay, C. & McFadden, D., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 255-265 11 p. (Methods in Molecular Biology; vol. 1826).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Suppression of collagen-induced arthritis with a serine proteinase inhibitor (serpin) derived from myxoma virus

Brahn, E., Lee, S., Lucas, A., McFadden, G. & MaCaulay, C., Aug 2014, In : Clinical Immunology. 153, 2, p. 254-263 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma

Tang, B., Guo, Z. S., Bartlett, D. L., Yan, D. Z., Schane, C. P., Thomas, D. L., Liu, J., McFadden, G., Shisler, J. L., Roy, E. J. & Roy, E. J., May 1 2020, In : Clinical Cancer Research. 26, 9, p. 2216-2230 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Tanapox virus

Barrett, J. W. & McFadden, D., Apr 19 2016, Molecular Detection of Human Viral Pathogens. CRC Press, p. 1039-1046 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Targeting gallbladder cancer: Oncolytic virotherapy with myxoma virus is enhanced by rapamycin in vitro and further improved by hyaluronan in vivo

Weng, M., Gong, W., Ma, M., Chu, B., Qin, Y., Zhang, M., Lun, X., McFadden, G., Forsyth, P., Yang, Y. & Quan, Z., Apr 13 2014, In : Molecular Cancer. 13, 1, 82.

Research output: Contribution to journalArticle

12 Scopus citations

The current status and future directions of myxoma virus, a master in immune evasion

Spiesschaert, B., McFadden, G., Hermans, K., Nauwynck, H. & Van De Walle, G. R., 2011, In : Veterinary Research. 42, 1, 76.

Research output: Contribution to journalReview article

28 Scopus citations

The poxvirus C7L host range factor superfamily

Liu, J., Rothenburg, S. & McFadden, G., Dec 2012, In : Current opinion in virology. 2, 6, p. 764-772 9 p.

Research output: Contribution to journalReview article

11 Scopus citations

Therapeutics for graft-versus-host disease: From conventional therapies to novel virotherapeutic strategies

Villa, N. Y., Rahman, M. M., McFadden, G. & Cogle, C. R., Mar 2016, In : Viruses. 8, 3, 85.

Research output: Contribution to journalReview article

4 Scopus citations

The serpin solution; targeting thrombotic and thrombolytic serine proteases in inflammation

Chen, H., Davids, J. A., Zheng, D., Bryant, M., Bot, I., van Berckel, T. J. C., Biessen, E., Pepine, C., Ryman, K., Progulski-Fox, A., Kesavalu, L., Moyer, R., McFadden, G. & Lucas, A., Jan 1 2013, In : Cardiovascular and Hematological Disorders - Drug Targets. 13, 2, p. 99-110 12 p.

Research output: Contribution to journalReview article

10 Scopus citations

The tanapoxvirus 15L protein is a virus-encoded neuregulin that promotes viral replication in human endothelial cells

Jeng, D., Ma, Z., Barrett, J. W., McFadden, G., Loeb, J. A. & Essania, K., Mar 2013, In : Journal of virology. 87, 6, p. 3018-3026 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

The virome: Viral ghost companion, virus wars

Lucas, A., Ambadapadi, S., Zheng, D., Chen, H., Lakshmyya, K., Progulske-Fox, A., Krafft, A., Bryant, M., O’Regan, S., Moyer, R., McFadden, G., Jobin, C. & Rand, K., Jan 1 2014, In : Journal of Clinical and Experimental Cardiology. 5, 8, e136.

Research output: Contribution to journalEditorial

1 Scopus citations

The wide utility of rabbits as models of human diseases

Esteves, P. J., Abrantes, J., Baldauf, H. M., BenMohamed, L., Chen, Y., Christensen, N., González-Gallego, J., Giacani, L., Hu, J., Kaplan, G., Keppler, O. T., Knight, K. L., Kong, X. P., Lanning, D. K., Le Pendu, J., De Matos, A. L., Liu, J., Liu, S., Lopes, A. M., Lu, S. & 17 others, Lukehart, S., Manabe, Y. C., Neves, F., McFadden, D., Pan, R., Peng, X., de Sousa-Pereira, P., Pinheiro, A., Rahman, M., Ruvoën-Clouet, N., Subbian, S., Tuñón, M. J., van der Loo, W., Vaine, M., Via, L. E., Wang, S. & Mage, R., May 2018, In : Experimental and Molecular Medicine. 50, 5, 66.

Research output: Contribution to journalArticle

24 Scopus citations

Treating brain tumor-initiating cells using a combination of myxoma virus and rapamycin

Zemp, F. J., Lun, X., McKenzie, B. A., Zhou, H., Maxwell, L., Sun, B., Kelly, J. J. P., Stechishin, O., Luchman, A., Weiss, S., Cairncross, J. G., Hamilton, M. G., Rabinovich, B. A., Rahman, M. M., Mohamed, M. R., Smallwood, S., Senger, D. L., Bell, J., McFadden, G. & Forsyth, P. A., Jul 2013, In : Neuro-Oncology. 15, 7, p. 904-920 17 p.

Research output: Contribution to journalArticle

24 Scopus citations

Tumor necrosis factor inhibitors from poxviruses with an emphasis on tanapoxvirus-2L protein

Jeng, D., Rahman, M. M., McFadden, G. & Essani, K., Aug 1 2011, In : Recent Patents on DNA and Gene Sequences. 5, 2, p. 97-103 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Vaccinia virus dissemination requires p21-activated kinase 1

Andrade, L. G., Albarnaz, J. D., Mügge, F. L. B., David, B. A., Abrahão, J. S., da Fonseca, F. G., Kroon, E. G., Menezes, G. B., McFadden, D. & Bonjardim, C. A., Nov 1 2016, In : Archives of Virology. 161, 11, p. 2991-3002 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Viral anti-inflammatory proteins target diverging immune pathways with converging effects on arterial dilatation, plaque and apoptosis

Davids, J. A., Dai, E., Chen, H., Bartee, M. Y., Liu, L., Fortunel, A., Moyer, R., Mcfadden, G. & Lucas, A. R., Jan 1 2014, In : European Journal of Inflammation. 12, 1, p. 131-145 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Viral serpin therapeutics: From concept to clinic

Chen, H., Zheng, D., Davids, J., Bartee, M. Y., Dai, E., Liu, L., Petrov, L., Macaulay, C., Thoburn, R., Sobel, E., Moyer, R., McFadden, D. & Lucas, A., Jun 24 2011, In : Methods in Enzymology. 499, p. 301-329 29 p.

Research output: Contribution to journalArticle

17 Scopus citations

Virotherapy as Potential Adjunct Therapy for Graft-Vs-Host Disease

Villa, N. Y. & McFadden, G., Dec 1 2018, In : Current Pathobiology Reports. 6, 4, p. 247-263 17 p.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

Virotherapy using Myxoma virus prevents lethal graft-versus-host disease following xeno-transplantation with primary human hematopoietic stem cells

Bartee, E., Meacham, A., Wise, E., Cogle, C. R. & McFadden, G., Aug 14 2012, In : PloS one. 7, 8, e43298.

Research output: Contribution to journalArticle

11 Scopus citations

Viruses for tumor therapy

Bell, J. & McFadden, G., Mar 12 2014, In : Cell Host and Microbe. 15, 3, p. 260-265 6 p.

Research output: Contribution to journalReview article

75 Scopus citations

White paper on microbial anti-cancer therapy and prevention

Forbes, N. S., Coffin, R. S., Deng, L., Evgin, L., Fiering, S., Giacalone, M., Gravekamp, C., Gulley, J. L., Gunn, H., Hoffman, R. M., Kaur, B., Liu, K., Lyerly, H. K., Marciscano, A. E., Moradian, E., Ruppel, S., Saltzman, D. A., Tattersall, P. J., Thorne, S., Vile, R. G. & 3 others, Zhang, H. H., Zhou, S. & McFadden, D., Aug 6 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 78.

Research output: Contribution to journalArticle

18 Scopus citations

Women in cardiology: The x factor and the heart of medicine

Lucas, A., Eaverly, M., McFadden, G. & Bryant, M., Feb 2014, In : Journal of Clinical and Experimental Cardiology. 5, 2

Research output: Contribution to journalEditorial