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2015
10 Citations (Scopus)

Microfluidic sorting of protein nanocrystals by size for X-ray free-electron laser diffraction

Abdallah, B. G., Zatsepin, N., Roy-Chowdhury, S., Coe, J., Conrad, C. E., Dörner, K., Sierra, R. G., Stevenson, H. P., Camacho-Alanis, F., Grant, T. D., Nelson, G., James, D., Calero, G., Wachter, R., Spence, J., Weierstall, U., Fromme, P. & Ros, A., Jul 1 2015, In : Structural Dynamics. 2, 4, 041719.

Research output: Contribution to journalArticle

X ray lasers
Free electron lasers
classifying
Sorting
Microfluidics
36 Citations (Scopus)

Serial femtosecond crystallography of soluble proteins in lipidic cubic phase

Fromme, R., Ishchenko, A., Metz, M., Chowdhury, S. R., Basu, S., Boutet, S., Fromme, P., White, T. A., Barty, A., Spence, J., Weierstall, U., Liu, W. & Cherezov, V., Sep 1 2015, In : IUCrJ. 2, p. 545-551 7 p.

Research output: Contribution to journalArticle

Crystallography
crystallography
Microcrystals
proteins
Proteins
9 Citations (Scopus)

Serial femtosecond X-ray diffraction of enveloped virus microcrystals

Lawrence, R. M., Conrad, C. E., Zatsepin, N., Grant, T. D., Liu, H., James, D., Nelson, G., Subramanian, G., Aquila, A., Hunter, M. S., Liang, M., Boutet, S., Coe, J., Spence, J., Weierstall, U., Liu, W., Fromme, P., Cherezov, V. & Hogue, B., Jul 1 2015, In : Structural Dynamics. 2, 4, 041720.

Research output: Contribution to journalArticle

Microcrystals
microcrystals
viruses
Viruses
X ray diffraction
22 Citations (Scopus)

Solving protein nanocrystals by cryo-EM diffraction: Multiple scattering artifacts

Subramanian, G., Basu, S., Liu, H., Zuo, J. M. & Spence, J., Jan 1 2015, In : Ultramicroscopy. 148, p. 87-93 7 p.

Research output: Contribution to journalArticle

Multiple scattering
Nanocrystals
artifacts
nanocrystals
Diffraction
96 Citations (Scopus)

Structural basis for bifunctional peptide recognition at human δ-opioid receptor

Fenalti, G., Zatsepin, N., Betti, C., Giguere, P., Han, G. W., Ishchenko, A., Liu, W., Guillemyn, K., Zhang, H., James, D., Wang, D., Weierstall, U., Spence, J., Boutet, S., Messerschmidt, M., Williams, G. J., Gati, C., Yefanov, O. M., White, T. A., Oberthuer, D. & 16 others, Metz, M., Yoon, C. H., Barty, A., Chapman, H. N., Basu, S., Coe, J., Conrad, C. E., Fromme, R., Fromme, P., Tourwé, D., Schiller, P. W., Roth, B. L., Ballet, S., Katritch, V., Stevens, R. C. & Cherezov, V., Mar 6 2015, In : Nature Structural and Molecular Biology. 22, 3, p. 265-268 4 p.

Research output: Contribution to journalArticle

Opioid Receptors
Peptides
Analgesics
Opiate Alkaloids
phenylalanylphenylalanine
90 Citations (Scopus)

The linac coherent light source single particle imaging road map

Aquila, A., Barty, A., Bostedt, C., Boutet, S., Carini, G., DePonte, D., Drell, P., Doniach, S., Downing, K. H., Earnest, T., Elmlund, H., Elser, V., Gühr, M., Hajdu, J., Hastings, J., Hau-Riege, S. P., Huang, Z., Lattman, E. E., Maia, F. R. N. C., Marchesini, S. & 10 others, Ourmazd, A., Pellegrini, C., Santra, R., Schlichting, I., Schroer, C., Spence, J., Vartanyants, I. A., Wakatsuki, S., Weis, W. I. & Williams, G. J., Jul 1 2015, In : Structural Dynamics. 2, 4, 041701.

Research output: Contribution to journalArticle

coherent light
Light sources
light sources
Free electron lasers
Imaging techniques
5 Citations (Scopus)

X-ray lasers and serial crystallography

Spence, J., Apr 30 2015, In : IUCrJ. 2, p. 305-306 2 p.

Research output: Contribution to journalArticle

X ray lasers
Crystallography
2014
29 Citations (Scopus)

7 Å resolution in protein twodimensional-crystal X-ray diffraction at Linac Coherent Light Source

Pedrini, B., Tsai, C. J., Capitani, G., Padeste, C., Hunter, M. S., Zatsepin, N., Barty, A., Henry Benner, W., Boutet, S., Feld, G. K., Hau-Riege, S. P., Kirian, R., Kupitz, C., Messerschmitt, M., Ogren, J. I., Pardini, T., Segelke, B., Williams, G. J., Spence, J., Abela, R. & 5 others, Coleman, M., Evans, J. E., Schertler, G. F. X., Frank, M. & Li, X. D., Jul 17 2014, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1647, 20130500.

Research output: Contribution to journalArticle

crystal proteins
X ray lasers
X-ray diffraction
X-Ray Diffraction
crystals
14 Citations (Scopus)

Ab-initio phasing using nanocrystal shape transforms with incomplete unit cells

Liu, H., Zatsepin, N. & Spence, J., Jan 1 2014, In : IUCrJ. 1, p. 19-27 9 p.

Research output: Contribution to journalArticle

Nanoparticles
Nanocrystals
nanocrystals
Crystals
cells
15 Citations (Scopus)

Approaches to time-resolved diffraction using an XFEL

Spence, J., Dec 1 2014, In : Faraday Discussions. 171, p. 429-438 10 p.

Research output: Contribution to journalArticle

Diffraction
delivery
recording
diffraction
Crystallography
11 Citations (Scopus)

Coherent convergent-beam time-resolved X-ray diffraction

Spence, J., Zatsepin, N. & Li, C., Jul 17 2014, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1647, 20130325.

Research output: Contribution to journalArticle

X ray lasers
nanocrystals
X-ray diffraction
X-Ray Diffraction
Nanocrystals
13 Citations (Scopus)

Direct phasing in femtosecond nanocrystallography. I. Diffraction characteristics

Chen, J. P. J., Spence, J. & Millane, R. P., 2014, In : Acta Crystallographica Section A: Foundations and Advances. 70, 2, p. 143-153 11 p.

Research output: Contribution to journalArticle

Nanoparticles
Noise
Diffraction
X-Rays
Crystallography
10 Citations (Scopus)

Direct phasing in femtosecond nanocrystallography. II. Phase retrieval

Chen, J. P. J., Spence, J. & Millane, R. P., 2014, In : Acta Crystallographica Section A: Foundations and Advances. 70, 2, p. 154-161 8 p.

Research output: Contribution to journalArticle

X ray lasers
Free electron lasers
Nanocrystals
Diffraction patterns
retrieval
43 Citations (Scopus)

Double-focusing mixing jet for XFEL study of chemical kinetics

Wang, D., Weierstall, U., Pollack, L. & Spence, J., Nov 1 2014, In : Journal of Synchrotron Radiation. 21, p. 1364-1366 3 p.

Research output: Contribution to journalArticle

Reaction kinetics
reaction kinetics
X-Rays
Equipment and Supplies
Motion Pictures
5 Citations (Scopus)

Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1

Lee, H. H., Cherni, I., Yu, H., Fromme, R., Doran, J. D., Grotjohann, I., Mittman, M., Basu, S., Deb, A., Dörner, K., Aquila, A., Barty, A., Boutet, S., Chapman, H. N., Doak, R. B., Hunter, M. S., James, D., Kirian, R., Kupitz, C., Lawrence, R. M. & 17 others, Liu, H., Nass, K., Schlichting, I., Schmidt, K., Seibert, M. M., Shoeman, R. L., Spence, J., Stellato, F., Weierstall, U., Williams, G. J., Yoon, C., Wang, D., Zatsepin, N., Hogue, B., Matoba, N., Fromme, P. & Leket-Mor, T., Aug 29 2014, In : IUCrJ. 1, p. 305-317 13 p.

Research output: Contribution to journalArticle

vaccines
human immunodeficiency virus
Vaccines
Crystallization
Viruses
54 Citations (Scopus)

Femtosecond X-ray diffraction from two-dimensional protein crystals

Frank, M., Carlson, D. B., Hunter, M. S., Williams, G. J., Messerschmidt, M., Zatsepin, N., Barty, A., Benner, W. H., Chu, K., Graf, A. T., Hau-Riege, S. P., Kirian, R., Padeste, C., Pardini, T., Pedrini, B., Segelke, B., Seibert, M. M., Spence, J., Tsai, C. J., Lane, S. M. & 5 others, Li, X. D., Schertler, G., Boutet, S., Coleman, M. & Evans, J. E., Feb 28 2014, In : IUCrJ. 1, p. 95-100 6 p.

Research output: Contribution to journalArticle

X-Ray Diffraction
X-Rays
proteins
Proteins
X ray diffraction
1 Citation (Scopus)

Instrumentation and methods: General discussion

Küpper, J., Williams, G., Chapman, H., Reid, K., Christensen, J., Wörner, H. J., Seddon, E., Dixit, G., Campbell, E., Underwood, J., Woerner, M., Spence, J., Van Thor, J., Wolf, M., Vendrell, O., De Ninno, G., Bressler, C. & Berrah, N., Dec 1 2014, In : Faraday Discussions. 171, p. 505-523 19 p.

Research output: Contribution to journalArticle

304 Citations (Scopus)

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

Weierstall, U., James, D., Wang, C., White, T. A., Wang, D., Liu, W., Spence, J., Bruce Doak, R., Nelson, G., Fromme, P., Fromme, R., Grotjohann, I., Kupitz, C., Zatsepin, N., Liu, H., Basu, S., Wacker, D., Won Han, G., Katritch, V., Boutet, S. & 17 others, Messerschmidt, M., Williams, G. J., Koglin, J. E., Marvin Seibert, M., Klinker, M., Gati, C., Shoeman, R. L., Barty, A., Chapman, H. N., Kirian, R., Beyerlein, K. R., Stevens, R. C., Li, D., Shah, S. T. A., Howe, N., Caffrey, M. & Cherezov, V., Feb 14 2014, In : Nature Communications. 5, 3309.

Research output: Contribution to journalArticle

Crystallography
injectors
crystallography
Membrane Proteins
membranes
22 Citations (Scopus)

Mapping the continuous reciprocal space intensity distribution of X-ray serial crystallography

Yefanov, O., Gati, C., Bourenkov, G., Kirian, R., White, T. A., Spence, J., Chapman, H. N. & Barty, A., Jul 17 2014, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1647, 20130333.

Research output: Contribution to journalArticle

crystallography
X ray lasers
Crystallography
X ray crystallography
Free electron lasers
1 Citation (Scopus)

Near edge fine structure analysis of copper in Cu-Bi<inf>2</inf>Se<inf>3</inf> topological insulators

Subramanian, G., Jiang, N., Chen, Y. & Spence, J., Aug 1 2014, In : Microscopy and Microanalysis. 20, 3, p. 160-161 2 p.

Research output: Contribution to journalArticle

fine structure
insulators
Copper
copper
271 Citations (Scopus)

Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser

Kupitz, C., Basu, S., Grotjohann, I., Fromme, R., Zatsepin, N., Rendek, K. N., Hunter, M. S., Shoeman, R. L., White, T. A., Wang, D., James, D., Yang, J. H., Cobb, D. E., Reeder, B., Sierra, R. G., Liu, H., Barty, A., Aquila, A. L., Deponte, D., Kirian, R. & 39 others, Bari, S., Bergkamp, J. J., Beyerlein, K. R., Bogan, M. J., Caleman, C., Chao, T. C., Conrad, C. E., Davis, K. M., Fleckenstein, H., Galli, L., Hau-Riege, S. P., Kassemeyer, S., Laksmono, H., Liang, M., Lomb, L., Marchesini, S., Martin, A. V., Messerschmidt, M., Milathianaki, D., Nass, K., Ros, A., Roy-Chowdhury, S., Schmidt, K., Seibert, M., Steinbrener, J., Stellato, F., Yan, L., Yoon, C., Moore, T., Moore, A., Pushkar, Y., Williams, G. J., Boutet, S., Doak, R. B., Weierstall, U., Frank, M., Chapman, H. N., Spence, J. & Fromme, P., Sep 11 2014, In : Nature. 513, 7517, p. 261-265 5 p.

Research output: Contribution to journalArticle

Crystallography
Photosystem II Protein Complex
Lasers
X-Rays
Photosynthesis

Solving protein nanocrystals by cryo-EM: Multiple scattering artifacts

Subramanian, G., Basu, S., Liu, H., Zuo, J. M. & Spence, J., Aug 1 2014, In : Microscopy and Microanalysis. 20, 3, p. 1242-1243 2 p.

Research output: Contribution to journalArticle

Multiple scattering
Nanocrystals
artifacts
nanocrystals
proteins
22 Citations (Scopus)

The birth of a new field

Spence, J. & Chapman, H. N., Jul 17 2014, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1647, 20130309.

Research output: Contribution to journalArticle

X ray lasers
X ray diffraction
Electrons
Lasers
18 Citations (Scopus)

The indexing ambiguity in serial femtosecond crystallography (SFX) resolved using an expectation maximization algorithm

Liu, H. & Spence, J., Oct 10 2014, In : IUCrJ. 1, p. 393-401 9 p.

Research output: Contribution to journalArticle

Crystallography
ambiguity
crystallography
Photosystem I Protein Complex
Diffraction patterns
224 Citations (Scopus)

Time-resolved serial crystallography captures high-resolution intermediates of photoactive yellow protein

Tenboer, J., Basu, S., Zatsepin, N., Pande, K., Milathianaki, D., Frank, M., Hunter, M., Boutet, S., Williams, G. J., Koglin, J. E., Oberthuer, D., Heymann, M., Kupitz, C., Conrad, C., Coe, J., Roy-Chowdhury, S., Weierstall, U., James, D., Wang, D., Grant, T. & 16 others, Barty, A., Yefanov, O., Scales, J., Gati, C., Seuring, C., Srajer, V., Henning, R., Schwander, P., Fromme, R., Ourmazd, A., Moffat, K., Van Thor, J. J., Spence, J., Fromme, P., Chapman, H. N. & Schmidt, M., Dec 5 2014, In : Science. 346, 6214, p. 1242-1246 5 p.

Research output: Contribution to journalArticle

Crystallography
Electrons
Light
Bacterial Proteins
Proteins
2 Citations (Scopus)

Time-resolved spectra from millivolt EELS data

Li, C., Subramanian, G. & Spence, J., 2014, In : Microscopy and Microanalysis. 20, 3, p. 837-846 10 p.

Research output: Contribution to journalArticle

Energy dissipation
energy dissipation
electron energy
Electrons
Electron microscopes

Trace phase detection and strain characterization from serial X-ray free-electron laser crystallography of a Pr

Beyerlein, K. R., Jooss, C., Barty, A., Bean, R., Boutet, S., Dhesi, S. S., Doak, R. B., Först, M., Galli, L., Kirian, R., Kozak, J., Lang, M., Mankowsky, R., Messerschmidt, M., Spence, J., Wang, D., Weierstall, U., White, T. A., Williams, G. J., Yefanov, O. & 3 others, Zatsepin, N., Cavalleri, A. & Chapman, H. N., Nov 17 2014, In : Powder Diffraction. 761

Research output: Contribution to journalArticle

X ray lasers
Crystallography
Free electron lasers
free electron lasers
Powders
3 Citations (Scopus)

Trace phase detection and strain characterization from serial X-ray free-electron laser crystallography of a Pr<inf>0.5</inf>Ca<inf>0.5</inf>MnO<inf>3</inf> powder

Beyerlein, K. R., Jooss, C., Barty, A., Bean, R., Boutet, S., Dhesi, S. S., Doak, R. B., Först, M., Galli, L., Kirian, R., Kozak, J., Lang, M., Mankowsky, R., Messerschmidt, M., Spence, J., Wang, D., Weierstall, U., White, T. A., Williams, G. J., Yefanov, O. & 3 others, Zatsepin, N., Cavalleri, A. & Chapman, H. N., Mar 3 2014, In : Powder Diffraction. 30, p. S25-S30

Research output: Contribution to journalArticle

X ray lasers
Crystallography
Free electron lasers
free electron lasers
Powders
107 Citations (Scopus)

Visualizing a protein quake with time-resolved X-ray scattering at a free-electron laser

Arnlund, D., Johansson, L. C., Wickstrand, C., Barty, A., Williams, G. J., Malmerberg, E., Davidsson, J., Milathianaki, D., DePonte, D. P., Shoeman, R. L., Wang, D., James, D., Katona, G., Westenhoff, S., White, T. A., Aquila, A., Bari, S., Berntsen, P., Bogan, M., Van Driel, T. B. & 26 others, Doak, R. B., Kjær, K. S., Frank, M., Fromme, R., Grotjohann, I., Henning, R., Hunter, M. S., Kirian, R., Kosheleva, I., Kupitz, C., Liang, M., Martin, A. V., Nielsen, M. M., Messerschmidt, M., Seibert, M. M., Sjöhamn, J., Stellato, F., Weierstall, U., Zatsepin, N., Spence, J., Fromme, P., Schlichting, I., Boutet, S., Groenhof, G., Chapman, H. N. & Neutze, R., 2014, In : Nature Methods. 11, 9, p. 923-926 4 p.

Research output: Contribution to journalArticle

Free electron lasers
X ray scattering
Lasers
X-Rays
Electrons
160 Citations (Scopus)

X-ray diffraction from isolated and strongly aligned gas-phase molecules with a free-electron laser

Küpper, J., Stern, S., Holmegaard, L., Filsinger, F., Rouzée, A., Rudenko, A., Johnsson, P., Martin, A. V., Adolph, M., Aquila, A., Bajt, S., Barty, A., Bostedt, C., Bozek, J., Caleman, C., Coffee, R., Coppola, N., Delmas, T., Epp, S., Erk, B. & 35 others, Foucar, L., Gorkhover, T., Gumprecht, L., Hartmann, A., Hartmann, R., Hauser, G., Holl, P., Hömke, A., Kimmel, N., Krasniqi, F., Kühnel, K. U., Maurer, J., Messerschmidt, M., Moshammer, R., Reich, C., Rudek, B., Santra, R., Schlichting, I., Schmidt, C., Schorb, S., Schulz, J., Soltau, H., Spence, J., Starodub, D., Strüder, L., Thøgersen, J., Vrakking, M. J. J., Weidenspointner, G., White, T. A., Wunderer, C., Meijer, G., Ullrich, J., Stapelfeldt, H., Rolles, D. & Chapman, H. N., Feb 28 2014, In : Physical Review Letters. 112, 8, 083002.

Research output: Contribution to journalArticle

free electron lasers
vapor phases
diffraction
molecules
x rays
1 Citation (Scopus)

X-ray lasers and crystallography

Spence, J., Apr 30 2014, In : IUCrJ. 1, p. 151-152 2 p.

Research output: Contribution to journalArticle

X ray lasers
Crystallography
X ray crystallography
2013
4 Citations (Scopus)

Casimir torque between birefringent plates with metamaterials

Chen, X. & Spence, J., Sep 2013, In : Physica Status Solidi (A) Applications and Materials Science. 210, 9, p. 1925-1932 8 p.

Research output: Contribution to journalArticle

Metamaterials
torque
Refractive index
Torque
refractivity
6 Citations (Scopus)

Development of coherent scattering and diffractive imaging and the COSMIC facility at the Advanced Light Source

Shapiro, D., Roy, S., Celestre, R., Chao, W., Doering, D., Howells, M., Kevan, S., Kilcoyne, D., Kirz, J., Marchesini, S., Seu, K. A., Schirotzek, A., Spence, J., Tyliszczak, T., Warwick, T., Voronov, D. & Padmore, H. A., 2013, In : Journal of Physics: Conference Series. 425, PART 19, 192011.

Research output: Contribution to journalArticle

coherent scattering
light sources
data transmission
cryogenic temperature
charge coupled devices
4 Citations (Scopus)

Lawrence Bragg, microdiffraction and X-ray lasers

Spence, J., 2013, In : Acta Crystallographica Section A: Foundations of Crystallography. 69, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

X ray lasers
Lasers
X ray microscopes
X-Rays
Proteins
301 Citations (Scopus)

Natively inhibited trypanosoma brucei cathepsin B structure determined by using an x-ray laser

Redecke, L., Nass, K., DePonte, D. P., White, T. A., Rehders, D., Barty, A., Stellato, F., Liang, M., Barends, T. R. M., Boutet, S., Williams, G. J., Messerschmidt, M., Seibert, M. M., Aquila, A., Arnlund, D., Bajt, S., Barth, T. B., Bogan, M. J., Caleman, C., Chao, T. C. & 29 others, Doak, R. B., Fleckenstein, H., Frank, M., Fromme, R., Galli, L., Grotjohann, I., Hunter, M. S., Johansson, L. C., Kassemeyer, S., Katona, G., Kirian, R., Koopmann, R., Kupitz, C., Lomb, L., Martin, A. V., Mogk, S., Neutze, R., Shoeman, R. L., Steinbrener, J., Timneanu, N., Wang, D., Weierstall, U., Zatsepin, N., Spence, J., Fromme, P., Schlichting, I., Duszenko, M., Betzel, C. & Chapman, H. N., Jan 11 2013, In : Science. 339, 6116, p. 227-230 4 p.

Research output: Contribution to journalArticle

Cathepsin B
Trypanosoma brucei brucei
Cysteine Proteases
Lasers
X-Rays
286 Citations (Scopus)

Serial femtosecond crystallography of G protein-coupled receptors

Liu, W., Wacker, D., Gati, C., Han, G. W., James, D., Wang, D., Nelson, G., Weierstall, U., Katritch, V., Barty, A., Zatsepin, N., Li, D., Messerschmidt, M., Boutet, S., Williams, G. J., Koglin, J. E., Seibert, M. M., Wang, C., Shah, S. T. A., Basu, S. & 13 others, Fromme, R., Kupitz, C., Rendek, K. N., Grotjohann, I., Fromme, P., Kirian, R., Beyerlein, K. R., White, T. A., Chapman, H. N., Caffrey, M., Spence, J., Stevens, R. C. & Cherezov, V., 2013, In : Science. 342, 6165, p. 1521-1524 4 p.

Research output: Contribution to journalArticle

Protein
Laser
Damage
Temperature
Radiation
65 Citations (Scopus)

Structure of a photosynthetic reaction centre determined by serial femtosecond crystallography

Johansson, L. C., Arnlund, D., Katona, G., White, T. A., Barty, A., Deponte, D. P., Shoeman, R. L., Wickstrand, C., Sharma, A., Williams, G. J., Aquila, A., Bogan, M. J., Caleman, C., Davidsson, J., Doak, R. B., Frank, M., Fromme, R., Galli, L., Grotjohann, I., Hunter, M. S. & 25 others, Kassemeyer, S., Kirian, R., Kupitz, C., Liang, M., Lomb, L., Malmerberg, E., Martin, A. V., Messerschmidt, M., Nass, K., Redecke, L., Seibert, M. M., Sjöhamn, J., Steinbrener, J., Stellato, F., Wang, D., Wahlgren, W. Y., Weierstall, U., Westenhoff, S., Zatsepin, N., Boutet, S., Spence, J., Schlichting, I., Chapman, H. N., Fromme, P. & Neutze, R., Dec 19 2013, In : Nature Communications. 4, 2911.

Research output: Contribution to journalArticle

Photosynthetic Reaction Center Complex Proteins
Crystallography
Microcrystals
X Ray Crystallography
X-Ray Diffraction
3 Citations (Scopus)

The extraction of single-particle diffraction patterns from a multiple-particle diffraction pattern

Martin, A. V., Morgan, A. J., Ekeberg, T., Loh, N. D., Maia, F. R. N. C., Wang, F., Spence, J. & Chapman, H. N., Jul 1 2013, In : Optics Express. 21, 13, p. 15102-15112 11 p.

Research output: Contribution to journalArticle

diffraction patterns
molecules
x rays
free electron lasers
recording
30 Citations (Scopus)

Three-dimensional single-particle imaging using angular correlations from X-ray laser data

Liu, H., Poon, B. K., Saldin, D. K., Spence, J. & Zwart, P. H., Jul 2013, In : Acta Crystallographica Section A: Foundations of Crystallography. 69, 4, a69.

Research output: Contribution to journalArticle

X ray lasers
angular correlation
Lasers
X-Rays
Scattering
8 Citations (Scopus)

Valence electron energy-loss spectroscopy study of ZrSiO4 and ZrO2

Jiang, N. & Spence, J., Nov 2013, In : Ultramicroscopy. 134, p. 68-76 9 p.

Research output: Contribution to journalArticle

Electron energy loss spectroscopy
energy dissipation
electron energy
valence
spectroscopy
2012
53 Citations (Scopus)

Femtosecond free-electron laser X-ray diffraction data sets for algorithm development

Kassemeyer, S., Steinbrener, J., Lomb, L., Hartmann, E., Aquila, A., Barty, A., Martin, A. V., Hampton, C. Y., Bajt, S., Barthelmess, M., Barends, T. R. M., Bostedt, C., Bott, M., Bozek, J. D., Coppola, N., Cryle, M., De Ponte, D. P., Doak, R. B., Epp, S. W., Erk, B. & 42 others, Fleckenstein, H., Foucar, L., Graafsma, H., Gumprecht, L., Hartmann, A., Hartmann, R., Hauser, G., Hirsemann, H., Hömke, A., Holl, P., Jönsson, O., Kimmel, N., Krasniqi, F., Liang, M., Maia, F. R. N. C., Marchesini, S., Nass, K., Reich, C., Rolles, D., Rudek, B., Rudenko, A., Schmidt, C., Schulz, J., Shoeman, R. L., Sierra, R. G., Soltau, H., Spence, J., Starodub, D., Stellato, F., Stern, S., Stier, G., Svenda, M., Weidenspointner, G., Weierstall, U., White, T. A., Wunderer, C., Frank, M., Chapman, H. N., Ullrich, J., Strüder, L., Bogan, M. J. & Schlichting, I., Feb 13 2012, In : Optics Express. 20, 4, p. 4149-4158 10 p.

Research output: Contribution to journalArticle

free electron lasers
diffraction
x rays
coherent light
viruses
511 Citations (Scopus)

High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography

Boutet, S., Lomb, L., Williams, G. J., Barends, T. R. M., Aquila, A., Doak, R. B., Weierstall, U., DePonte, D. P., Steinbrener, J., Shoeman, R. L., Messerschmidt, M., Barty, A., White, T. A., Kassemeyer, S., Kirian, R., Seibert, M. M., Montanez, P. A., Kenney, C., Herbst, R., Hart, P. & 34 others, Pines, J., Haller, G., Gruner, S. M., Philipp, H. T., Tate, M. W., Hromalik, M., Koerner, L. J., Van Bakel, N., Morse, J., Ghonsalves, W., Arnlund, D., Bogan, M. J., Caleman, C., Fromme, R., Hampton, C. Y., Hunter, M. S., Johansson, L. C., Katona, G., Kupitz, C., Liang, M., Martin, A. V., Nass, K., Redecke, L., Stellato, F., Timneanu, N., Wang, D., Zatsepin, N., Schafer, D., Defever, J., Neutze, R., Fromme, P., Spence, J., Chapman, H. N. & Schlichting, I., Jul 20 2012, In : Science. 337, 6092, p. 362-364 3 p.

Research output: Contribution to journalArticle

Crystallography
X-Rays
Synchrotrons
Muramidase
Proteins
144 Citations (Scopus)

Injector for scattering measurements on fully solvated biospecies

Weierstall, U., Spence, J. & Doak, R. B., Mar 2012, In : Review of Scientific Instruments. 83, 3, 035108.

Research output: Contribution to journalArticle

injectors
Gases
Scattering
Gas dynamics
Vacuum
126 Citations (Scopus)

In vivo protein crystallization opens new routes in structural biology

Koopmann, R., Cupelli, K., Redecke, L., Nass, K., Deponte, D. P., White, T. A., Stellato, F., Rehders, D., Liang, M., Andreasson, J., Aquila, A., Bajt, S., Barthelmess, M., Barty, A., Bogan, M. J., Bostedt, C., Boutet, S., Bozek, J. D., Caleman, C., Coppola, N. & 49 others, Davidsson, J., Doak, R. B., Ekeberg, T., Epp, S. W., Erk, B., Fleckenstein, H., Foucar, L., Graafsma, H., Gumprecht, L., Hajdu, J., Hampton, C. Y., Hartmann, A., Hartmann, R., Hauser, G., Hirsemann, H., Holl, P., Hunter, M. S., Kassemeyer, S., Kirian, R., Lomb, L., Maia, F. R. N. C., Kimmel, N., Martin, A. V., Messerschmidt, M., Reich, C., Rolles, D., Rudek, B., Rudenko, A., Schlichting, I., Schulz, J., Seibert, M. M., Shoeman, R. L., Sierra, R. G., Soltau, H., Stern, S., Strülder, L., Timneanu, N., Ullrich, J., Wang, X., Weidenspointner, G., Weierstall, U., Williams, G. J., Wunderer, C. B., Fromme, P., Spence, J., Stehle, T., Chapman, H. N., Betzel, C. & Duszenko, M., Mar 2012, In : Nature Methods. 9, 3, p. 259-262 4 p.

Research output: Contribution to journalArticle

Trypanosoma brucei brucei
Crystallography
Systems Biology
Crystallization
Lasers
120 Citations (Scopus)

Lipidic phase membrane protein serial femtosecond crystallography

Johansson, L. C., Arnlund, D., White, T. A., Katona, G., Deponte, D. P., Weierstall, U., Doak, R. B., Shoeman, R. L., Lomb, L., Malmerberg, E., Davidsson, J., Nass, K., Liang, M., Andreasson, J., Aquila, A., Bajt, S., Barthelmess, M., Barty, A., Bogan, M. J., Bostedt, C. & 48 others, Bozek, J. D., Caleman, C., Coffee, R., Coppola, N., Ekeberg, T., Epp, S. W., Erk, B., Fleckenstein, H., Foucar, L., Graafsma, H., Gumprecht, L., Hajdu, J., Hampton, C. Y., Hartmann, R., Hartmann, A., Hauser, G., Hirsemann, H., Holl, P., Hunter, M. S., Kassemeyer, S., Kimmel, N., Kirian, R., Maia, F. R. N. C., Marchesini, S., Martin, A. V., Reich, C., Rolles, D., Rudek, B., Rudenko, A., Schlichting, I., Schulz, J., Seibert, M. M., Sierra, R. G., Soltau, H., Starodub, D., Stellato, F., Stern, S., Strülder, L., Timneanu, N., Ullrich, J., Wahlgren, W. Y., Wang, X., Weidenspointner, G., Wunderer, C., Fromme, P., Chapman, H. N., Spence, J. & Neutze, R., Mar 2012, In : Nature Methods. 9, 3, p. 263-265 3 p.

Research output: Contribution to journalArticle

X ray lasers
Crystallography
Free electron lasers
Porifera
Membrane Proteins
7 Citations (Scopus)

Microscopic linear liquid streams in vacuum: Injection of solvated biological samples into X-ray free electron lasers

Doak, R. B., Deponte, D. P., Nelson, G., Camacho-Alanis, F., Ros, A., Spence, J. & Weierstall, U., 2012, AIP Conference Proceedings. 1 ed. Vol. 1501. p. 1314-1323 10 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

gas dynamics
free electron lasers
free flow
injection
vacuum
46 Citations (Scopus)

On the dose-rate threshold of beam damage in TEM

Jiang, N. & Spence, J., Feb 2012, In : Ultramicroscopy. 113, p. 77-82 6 p.

Research output: Contribution to journalArticle

Transmission electron microscopy
damage
Recovery
dosage
transmission electron microscopy
2 Citations (Scopus)

Phase retrieval in femtosecond X-ray nanocrystallography

Chen, J. P. J., Spence, J. & Millane, R. P., 2012, ACM International Conference Proceeding Series. p. 43-48 6 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Diffraction
Charge density
X rays
Crystals
X ray crystallography

Phase retrieval in nanocrystallography

Chen, J. P. J., Spence, J. & Millane, R. P., 2012, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 8500. 85000I

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Phase Retrieval
retrieval
Diffraction
Crystal
diffraction
237 Citations (Scopus)

Self-terminating diffraction gates femtosecond X-ray nanocrystallography measurements

Barty, A., Caleman, C., Aquila, A., Timneanu, N., Lomb, L., White, T. A., Andreasson, J., Arnlund, D., Bajt, S., Barends, T. R. M., Barthelmess, M., Bogan, M. J., Bostedt, C., Bozek, J. D., Coffee, R., Coppola, N., Davidsson, J., Deponte, D. P., Doak, R. B., Ekeberg, T. & 48 others, Elser, V., Epp, S. W., Erk, B., Fleckenstein, H., Foucar, L., Fromme, P., Graafsma, H., Gumprecht, L., Hajdu, J., Hampton, C. Y., Hartmann, R., Hartmann, A., Hauser, G., Hirsemann, H., Holl, P., Hunter, M. S., Johansson, L., Kassemeyer, S., Kimmel, N., Kirian, R., Liang, M., Maia, F. R. N. C., Malmerberg, E., Marchesini, S., Martin, A. V., Nass, K., Neutze, R., Reich, C., Rolles, D., Rudek, B., Rudenko, A., Scott, H., Schlichting, I., Schulz, J., Marvin Seibert, M., Shoeman, R. L., Sierra, R. G., Soltau, H., Spence, J., Stellato, F., Stern, S., Strüder, L., Ullrich, J., Wang, X., Weidenspointner, G., Weierstall, U., Wunderer, C. B. & Chapman, H. N., Jan 2012, In : Nature Photonics. 6, 1, p. 35-40 6 p.

Research output: Contribution to journalArticle

X ray lasers
Free electron lasers
stopping
Diffraction
Crystalline materials