Tsafrir Leket-Mor

Research output

Research output per year 1993 2021

• 1369 Citations
• 22 h-Index
• 44 Article
• 5 Comment/debate
• 3 Review article
• 2 Chapter

Research output per year

Research output per year

Search results

• 2021

  Production of igg fusion proteins transiently expressed in nicotiana benthamiana

  Kamzina, A. S., Dipalma, M. P., Hunter, J. G. L., Diamos, A. G., Armer, B., Mor, T. S. & Mason, H. S., Jan 2021, In: Journal of Visualized Experiments. 2021, 167, p. 1-24 24 p., e61774.

  Research output: Contribution to journal › Article › peer-review

  • Tobacco
  • Antibodies
  • Proteins
  • Fusion reactions
  • Green Fluorescent Proteins
• 2020

  A plant-derived cocaine hydrolase prevents cocaine overdose lethality and attenuates cocaine-induced drug seeking behavior

  Larrimore, K. E., Kannan, L., Kendle, R. P., Jamal, T., Barcus, M., Stefanko, K., Kilbourne, J., Brimijoin, S., Zhan, C. G., Neisewander, J. & Mor, T. S., Aug 30 2020, In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 102, 109961.

  Research output: Contribution to journal › Article › peer-review

  • Drug-Seeking Behavior
  • Hydrolases
  • Cocaine
  • Enzymes
  • Enzyme Therapy
  1 Scopus citations
• • virus-like particle vaccines
  • Zika virus
  • Virus-Like Particle Vaccines
  • antigen-antibody complex
  • immunogenicity
  3 Scopus citations

• Codelivery of improved immune complex and virus-like particle vaccines containing Zika virus envelope domain III synergistically enhances immunogenicity

  Diamos, A. G., Pardhe, M. D., Sun, H., Hunter, J. G. L., Mor, T., Meador, L., Kilbourne, J., Chen, Q. & Mason, H. S., Apr 16 2020, In: Vaccine. 38, 18, p. 3455-3463 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • virus-like particle vaccines
  • Zika virus
  • Virus-Like Particle Vaccines
  • antigen-antibody complex
  • immunogenicity
  3 Scopus citations
• 2017
  • Vaccinia virus
  • Virion
  • Epitopes
  • Plant Viruses
  • AIDS Vaccines
  3 Scopus citations

• A heterologous prime-boosting strategy with replicating Vaccinia virus vectors and plant-produced HIV-1 Gag/dgp41 virus-like particles

  Meador, L. R., Kessans, S. A., Kilbourne, J., Kibler, K., Pantaleo, G., Roderiguez, M. E., Blattman, J., Jacobs, B. & Leket-Mor, T., Jul 1 2017, In: Virology. 507, p. 242-256 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Vaccinia virus
  • Virion
  • Epitopes
  • Plant Viruses
  • AIDS Vaccines
  3 Scopus citations

• Bacterial expression, correct membrane targeting and functional folding of the HIV-1 membrane protein Vpu using a periplasmic signal peptide

  Deb, A., Johnson, W. A., Kline, A. P., Scott, B. J., Meador, L. R., Srinivas, D., Martin-Garcia, J. M., Dörner, K., Borges, C., Misra, R., Hogue, B., Fromme, P. & Leket-Mor, T., Feb 2017, In: PloS one. 12, 2, e0172529.

  Research output: Contribution to journal › Article › peer-review

  • Human immunodeficiency virus 1
  • pectate lyase
  • viral proteins
  • Protein Sorting Signals
  • Viral Proteins
  4 Scopus citations

• Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity

  Larrimore, K. E., Kazan, I. C., Kannan, L., Kendle, R. P., Jamal, T., Barcus, M., Bolia, A., Brimijoin, S., Zhan, C. G., Ozkan, S. & Leket-Mor, T., Dec 1 2017, In: Scientific reports. 7, 1, 10419.

  Research output: Contribution to journal › Article › peer-review

  • Butyrylcholinesterase
  • Cholinesterases
  • Hydrolases
  • Cocaine
  • Enzymes
  13 Scopus citations
• 2016

  Immunological characterization of plant-based HIV-1 Gag/Dgp41 virus-like particles

  Kessans, S. A., Linhart, M. D., Meador, L. R., Kilbourne, J., Hogue, B., Fromme, P., Matoba, N. & Leket-Mor, T., Mar 2016, In: PloS one. 11, 3, e0151842.

  Research output: Contribution to journal › Article › peer-review

  • virus-like particles
  • Human immunodeficiency virus 1
  • Viruses
  • Virion
  • Membranes
  7 Scopus citations
• 2015

  Biophysical characterization of a vaccine candidate against HIV-1: The transmembrane and membrane proximal domains of HIV-1 gp41 as a maltose binding protein fusion

  Gong, Z., Martin-Garcia, J. M., Daskalova, S. M., Craciunescu, F. M., Song, L., Dörner, K., Hansen, D., Yang, J. H., LaBaer, J., Hogue, B., Leket-Mor, T. & Fromme, P., Aug 21 2015, In: PloS one. 10, 8, e0136507.

  Research output: Contribution to journal › Article › peer-review

  • Maltose-Binding Proteins
  • Human immunodeficiency virus 1
  • maltose
  • binding proteins
  • vaccines
  3 Scopus citations
• 2014

  Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1

  Lee, H. H., Cherni, I., Yu, H., Fromme, R., Doran, J. D., Grotjohann, I., Mittman, M., Basu, S., Deb, A., Dörner, K., Aquila, A., Barty, A., Boutet, S., Chapman, H. N., Doak, R. B., Hunter, M. S., James, D., Kirian, R., Kupitz, C., Lawrence, R. M. & 17 others, Liu, H., Nass, K., Schlichting, I., Schmidt, K., Seibert, M. M., Shoeman, R. L., Spence, J., Stellato, F., Weierstall, U., Williams, G. J., Yoon, C., Wang, D., Zatsepin, N., Hogue, B., Matoba, N., Fromme, P. & Leket-Mor, T., Aug 29 2014, In: IUCrJ. 1, p. 305-317 13 p.

  Research output: Contribution to journal › Article › peer-review

  • vaccines
  • human immunodeficiency virus
  • Vaccines
  • Crystallization
  • Viruses
  6 Scopus citations

• Expression of human butyrylcholinesterase with an engineered glycosylation profile resembling the plasma-derived orthologue

  Schneider, J. D., Castilho, A., Neumann, L., Altmann, F., Loos, A., Kannan, L., Leket-Mor, T. & Steinkellner, H., Apr 2014, In: Biotechnology Journal. 9, 4, p. 501-510 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Butyrylcholinesterase
  • Glycosylation
  • Polysaccharides
  • Nerve Agents
  • Extracellular Fluid
  35 Scopus citations

• Meeting report VLPNPV: Session 5: Plant based technology

  Meador, L. R. & Leket-Mor, T., Oct 1 2014, In: Human Vaccines and Immunotherapeutics. 10, 10, p. 3068-3073 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Virion
  • Congresses
  • Technology
  • Nanoparticles
  • Plant Development
  4 Scopus citations

• Oligomerization status influences subcellular deposition and glycosylation of recombinant butyrylcholinesterase in Nicotiana benthamiana

  Schneider, J. D., Marillonnet, S., Castilho, A., Gruber, C., Werner, S., Mach, L., Klimyuk, V., Leket-Mor, T. & Steinkellner, H., Sep 2014, In: Plant Biotechnology Journal. 12, 7, p. 832-839 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Butyrylcholinesterase
  • oligomerization
  • Nicotiana benthamiana
  • cholinesterase
  • Glycosylation
  29 Scopus citations

• Recombinant expression, purification, and biophysical characterization of the transmembrane and membrane proximal domains of HIV-1 gp41

  Gong, Z., Kessans, S. A., Song, L., Dörner, K., Lee, H. H., Meador, L. R., LaBaer, J., Hogue, B., Leket-Mor, T. & Fromme, P., Nov 1 2014, In: Protein Science. 23, 11, p. 1607-1618 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Purification
  • Characterization (materials science)
  • Membranes
  • Neutralizing Antibodies
  • Glycoproteins
  5 Scopus citations
• 2013

  Biological and biochemical characterization of HIV-1 Gag/dgp41 virus-like particles expressed in Nicotiana benthamiana

  Kessans, S. A., Linhart, M. D., Matoba, N. & Leket-Mor, T., Aug 2013, In: Plant Biotechnology Journal. 11, 6, p. 681-690 10 p.

  Research output: Contribution to journal › Article › peer-review

  • virus-like particles
  • Human immunodeficiency virus 1
  • Nicotiana benthamiana
  • Virion
  • Tobacco
  23 Scopus citations

• Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity

  Larrimore, K. E., Barcus, M., Kannan, L., Gao, Y., Zhan, C. G., Brimijoin, S. & Leket-Mor, T., Mar 25 2013, In: Chemico-Biological Interactions. 203, 1, p. 217-220 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Butyrylcholinesterase
  • Hydrolases
  • Cocaine
  • Pathogens
  • Cocaine-Related Disorders
  12 Scopus citations

• Reversal of Succinylcholine Induced Apnea with an Organophosphate Scavenging Recombinant Butyrylcholinesterase

  Geyer, B. C., Larrimore, K. E., Kilbourne, J., Kannan, L. & Leket-Mor, T., Mar 11 2013, In: PloS one. 8, 3, e59159.

  Research output: Contribution to journal › Article › peer-review

  • suxamethonium
  • apnea
  • Butyrylcholinesterase
  • Scavenging
  • Succinylcholine
  5 Scopus citations

• The Arabidopsis thaliana ortholog of a purported maize cholinesterase gene encodes a GDSL-lipase

  Muralidharan, M., Buss, K., Larrimore, K. E., Segerson, N. A., Kannan, L. & Leket-Mor, T., Apr 2013, In: Plant Molecular Biology. 81, 6, p. 565-576 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Arabidopsis
  • Zea mays
  • Cholinesterases
  • cholinesterase
  • Acetylcholinesterase
  5 Scopus citations
• 2012

  Nicotinic stimulation induces Tristetraprolin over-production and attenuates inflammation in muscle

  Geyer, B. C., Ben Ari, S., Barbash, S., Kilbourne, J., Leket-Mor, T. & Soreq, H., Feb 2012, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1823, 2, p. 368-378 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Tristetraprolin
  • Paraoxon
  • Cholinergic Agents
  • Muscles
  • Inflammation
  4 Scopus citations
• 2011

  Humoral immunogenicity of an HIV-1 envelope residue 649-684 membrane-proximal region peptide fused to the plague antigen F1-V

  Matoba, N., Shah, N. R. & Leket-Mor, T., Aug 5 2011, In: Vaccine. 29, 34, p. 5584-5590 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Plague
  • plague
  • Human immunodeficiency virus 1
  • immunogenicity
  • immunization
  7 Scopus citations
• 2010

  Plant-derived human butyrylcholinesterase, but not an organophosphorous- compound hydrolyzing variant thereof, protects rodents against nerve agents

  Geyer, B. C., Kannan, L., Garnaud, P. E., Broomfield, C. A., Cadieux, C. L., Cherni, I., Hodgins, S. M., Kasten, S. A., Kelley, K., Kilbourne, J., Oliver, Z. P., Otto, T. C., Puffenberger, I., Reeves, T. E., Robbins, N., Woods, R. R., Soreq, H., Lenz, D. E., Cerasoli, D. M. & Leket-Mor, T., Nov 23 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 47, p. 20251-20256 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Nerve Agents
  • Butyrylcholinesterase
  • Acid Anhydride Hydrolases
  • Pesticides
  • Acetylcholinesterase
  61 Scopus citations

• Transgenic plants as a source for the bioscavenging enzyme, human butyrylcholinesterase

  Geyer, B. C., Kannan, L., Cherni, I., Woods, R. R., Soreq, H. & Leket-Mor, T., Oct 2010, In: Plant Biotechnology Journal. 8, 8, p. 873-886 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Genetically Modified Plants
  • Butyrylcholinesterase
  • cholinesterase
  • transgenic plants
  • Enzymes
  47 Scopus citations
• 2009

  Biochemical and immunological characterization of the plant-derived candidate human immunodeficiency virus type 1 mucosal vaccine CTB-MPR _649-684

  Matoba, N., Kajiura, H., Cherni, I., Doran, J. D., Bomsel, M., Fujiyama, K. & Leket-Mor, T., Feb 2009, In: Plant Biotechnology Journal. 7, 2, p. 129-145 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Human immunodeficiency virus 1
  • vaccines
  • Vaccines
  • G(M1) Ganglioside
  • gangliosides
  44 Scopus citations
• 2008
  • Sperm Motility
  • Acetylcholinesterase
  • Germ Cells
  • Cells
  • Spermatozoa
  31 Scopus citations

• Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility

  Mor, I., Sklan, E. H., Podoly, E., Pick, M., Kirschner, M., Yogev, L., Bar-Sheshet Itach, S., Schreiber, L., Geyer, B., Leket-Mor, T., Grisaru, D. & Soreq, H., Apr 2008, In: Journal of Cellular and Molecular Medicine. 12, 2, p. 479-495 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Sperm Motility
  • Acetylcholinesterase
  • Germ Cells
  • Cells
  • Spermatozoa
  31 Scopus citations

• Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathology

  Berson, A., Knobloch, M., Hanan, M., Diamant, S., Sharoni, M., Schuppli, D., Geyer, B. C., Ravid, R., Leket-Mor, T., Nitsch, R. M. & Soreq, H., Jan 2008, In: Brain. 131, 1, p. 109-119 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Acetylcholinesterase
  • Amyloid
  • Pathology
  • Alzheimer Disease
  • Cholinergic Agents
  89 Scopus citations

• Hairy-root organ cultures for the production of human acetylcholinesterase

  Woods, R. R., Geyer, B. C. & Leket-Mor, T., Dec 23 2008, In: BMC Biotechnology. 8, 95.

  Research output: Contribution to journal › Article › peer-review

  • Organ Culture Techniques
  • Acetylcholinesterase
  • Genetically Modified Plants
  • Enzymes
  • Chemical Warfare Agents
  34 Scopus citations
• 2007

  Adaptive changes in acetylcholinesterase gene expression as mediators of recovery from chemical and biological insults

  Evron, T., Greenberg, D., Leket-Mor, T. & Soreq, H., Apr 20 2007, In: Toxicology. 233, 1-3 SPEC. ISS., p. 97-107 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Paraoxon
  • Acetylcholinesterase
  • Gene expression
  • R peptide
  • Lipopolysaccharides
  22 Scopus citations

• Plant-derived human acetylcholinesterase-R provides protection from lethal organophosphate poisoning and its chronic aftermath

  Evron, T., Geyer, B. C., Cherni, I., Muralidharan, M., Kilbourne, J., Fletcher, S. P., Soreq, H. & Leket-Mor, T., Sep 2007, In: FASEB Journal. 21, 11, p. 2961-2969 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Organophosphate Poisoning
  • Organophosphates
  • organophosphorus compounds
  • Acetylcholinesterase
  • paraoxon
  32 Scopus citations

• Translational control of recombinant human acetylcholinesterase accumulation in plants

  Geyer, B. C., Fletcher, S. P., Griffin, T. A., Lopker, M. J., Soreq, H. & Leket-Mor, T., May 30 2007, In: BMC Biotechnology. 7, 27.

  Research output: Contribution to journal › Article › peer-review

  • Acetylcholinesterase
  • Codon
  • Gene Expression
  • Messenger RNA
  • Genetically Modified Plants
  18 Scopus citations
• 2006

  Humoral immune responses by prime-boost heterologous route immunizations with CTB-MPR_649-684, a mucosal subunit HIV/AIDS vaccine candidate

  Matoba, N., Geyer, B. C., Kilbourne, J., Alfsen, A., Bomsel, M. & Leket-Mor, T., Jun 5 2006, In: Vaccine. 24, 23, p. 5047-5055 9 p.

  Research output: Contribution to journal › Article › peer-review

  • AIDS Vaccines
  • Subunit Vaccines
  • humoral immunity
  • Humoral Immunity
  • immunization
  44 Scopus citations

• Production of rotavirus-like particles in tomato (Lycopersicon esculentum L.) fruit by expression of capsid proteins VP2 and VP6 and immunological studies

  Saldaña, S., Guadarrama, F. E., Olivera Flores, T. D. J., Arias, N., López, S., Arias, C., Ruiz-Medrano, R., Mason, H., Leket-Mor, T., Richter, L., Arntzen, C. J. & Gómez Lim, M. A., 2006, In: Viral Immunology. 19, 1, p. 42-53 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Lycopersicon esculentum
  • Rotavirus
  • Capsid Proteins
  • Fruit
  • Virion
  34 Scopus citations
• 2005

  (32) Characterizing pea acetylcholinesterase

  Muralidharan, M., Soreq, H. & Leket-Mor, T., Dec 15 2005, In: Chemico-Biological Interactions. 157-158, p. 406-407 2 p.

  Research output: Contribution to journal › Article › peer-review

  • Peas
  • Cholinesterases
  • Neurology
  • Acetylcholinesterase
  • Cholinergic Agents
  4 Scopus citations

• Purification of transgenic plant-derived recombinant human acetylcholinesterase-R

  Geyer, B. C., Muralidharan, M., Cherni, I., Doran, J., Fletcher, S. P., Evron, T., Soreq, H. & Leket-Mor, T., Dec 15 2005, In: Chemico-Biological Interactions. 157-158, p. 331-334 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Genetically Modified Plants
  • Purification
  • Acetylcholinesterase
  • Plant Proteins
  • Affinity chromatography
  24 Scopus citations
• 2004

  Tissue distribution of cholinesterases and anticholinesterases in native and transgenic tomato plants

  Fletcher, S. P., Geyer, B. C., Smith, A., Evron, T., Joshi, L., Soreq, H. & Leket-Mor, T., May 2004, In: Plant Molecular Biology. 55, 1, p. 33-43 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Genetically Modified Plants
  • Lycopersicon esculentum
  • Cholinesterases
  • Cholinesterase Inhibitors
  • cholinesterase
  12 Scopus citations
• 2003

  Geminivirus vectors for high-level expression of foreign proteins in plant cells

  Leket-Mor, T., Moon, Y. S., Palmer, K. E. & Mason, H., Feb 20 2003, In: Biotechnology and bioengineering. 81, 4, p. 430-437 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Geminiviridae
  • replication initiator protein
  • Plant Cells
  • Chickpea chlorotic dwarf virus
  • Proteins
  66 Scopus citations
• 2001
  • Genetically Modified Plants
  • Lycopersicon esculentum
  • Acetylcholinesterase
  • Proteins
  • Fruit Proteins
  53 Scopus citations

• Expression of recombinant human acetylcholinesterase in transgenic tomato plants

  Mor, T. S., Sternfeld, M., Soreq, H., Arntzen, C. J. & Mason, H. S., Nov 5 2001, In: Biotechnology and bioengineering. 75, 3, p. 259-266 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Genetically Modified Plants
  • Lycopersicon esculentum
  • Acetylcholinesterase
  • Proteins
  • Fruit Proteins
  53 Scopus citations
• 1998

  Perspective: Edible vaccines - A concept coming of age

  Mor, T. S., Gómez-Lim, M. A. & Palmer, K. E., Nov 1 1998, In: Trends in microbiology. 6, 11, p. 449-453 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Edible Vaccines
  • Plant Antigens
  • Genetically Modified Plants
  • Vaccines
  • Developing Countries
  59 Scopus citations
• 1997

  The fate of cytochrome b₅₅₉ during anaerobic photoinhibition and its recovery processes

  Mor, T. S., Hundal, T., Ohad, I. & Andersson, B., Jan 1 1997, In: Photosynthesis research. 53, 2-3, p. 205-213 9 p.

  Research output: Contribution to journal › Article › peer-review

  • cytochrome b559
  • Photosystem II Protein Complex
  • photoinhibition
  • cytochromes
  • photosystem II
  9 Scopus citations
• 1995

  An unusual organization of the genes encoding cytochrome b₅₅₉ in Chlamydomonas reinhardtii: psbE and psbF genes are separately transcribed from different regions of the plastid chromosome

  Mor, T. S., Ohad, I., Hirschberg, J. & Pakrasi, H. B., Sep 1 1995, In: MGG Molecular & General Genetics. 246, 5, p. 600-604 5 p.

  Research output: Contribution to journal › Article › peer-review

  • cytochrome b559
  • Plastids
  • Chlamydomonas reinhardtii
  • Chromosomes
  • Operon
  21 Scopus citations
• 1994

  The ctpA gene encodes the C-terminal processing protease for the D1 protein of the photosystem II reaction center complex

  Anbudurai, P. R., Mor, T. S., Ohad, I., Shestakov, S. V. & Pakrasi, H. B., Aug 16 1994, In: Proceedings of the National Academy of Sciences of the United States of America. 91, 17, p. 8082-8086 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Photosystem II Protein Complex
  • Peptide Hydrolases
  • Genes
  • cytochrome b559
  • Water
  131 Scopus citations
• 1993

  The manganese stabilising protein (MSP) of Prochlorothrix hollandica is a hydrophobic membrane-bound protein

  Mor, T. S., Post, A. F. & Ohad, I., Mar 1 1993, In: BBA - Bioenergetics. 1141, 2-3, p. 206-212 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Prochlorothrix
  • Cyanobacteria
  • Manganese
  • Photosystem II Protein Complex
  • Membranes
  11 Scopus citations