Karen Kibler

Assistant Research Professor

  • 1424 Citations
  • 20 h-Index
19972019

Research output per year

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Research Output

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A designed “Nested” dimer of cyanovirin-N increases antiviral activity

Woodrum, B. W., Maxwell, J., Allen, D. M., Wilson, J., Krumpe, L. R. H., Bobkov, A. A., Hill, R. B., Kibler, K., O’Keefe, B. R. & Ghirlanda, G., Jun 6 2016, In : Viruses. 8, 6, 158.

Research output: Contribution to journalArticle

2 Scopus citations

A heterologous prime-boosting strategy with replicating Vaccinia virus vectors and plant-produced HIV-1 Gag/dgp41 virus-like particles

Meador, L. R., Kessans, S. A., Kilbourne, J., Kibler, K., Pantaleo, G., Roderiguez, M. E., Blattman, J., Jacobs, B. & Leket-Mor, T., Jul 1 2017, In : Virology. 507, p. 242-256 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

A multivalent HIV-1 fusion inhibitor based on small helical foldamers

Guarise, C., Shinde, S., Kibler, K., Ghirlanda, G., Prins, L. J. & Scrimin, P., Jun 10 2012, In : Tetrahedron. 68, 23, p. 4346-4352 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
41 Scopus citations

Comparison of immunogenicity in rhesus macaques of transmitted-founder, HIV-1 Group M consensus, and trivalent mosaic envelope vaccines formulated as a DNA prime, NYVAC, and envelope protein boost

Hulot, S. L., Korber, B., Giorgi, E. E., Vandergrift, N., Saunders, K. O., Balachandran, H., Mach, L. V., Lifton, M. A., Pantaleo, G., Tartaglia, J., Phogat, S., Jacobs, B., Kibler, K., Perdiguero, B., Gomez, C. E., Esteban, M., Rosati, M., Felber, B. K., Pavlakis, G. N., Parks, R. & 10 others, Lloyd, K., Sutherland, L., Scearce, R., Letvin, N. L., Seaman, M. S., Alam, S. M., Montefiori, D., Liao, H. X., Haynes, B. F. & Santra, S., Jan 1 2015, In : Journal of virology. 89, 12, p. 6462-6480 19 p.

Research output: Contribution to journalArticle

25 Scopus citations

Complementation of vaccinia virus deleted of the E3L gene by mutants of E3L

Shors, T., Kibler, K., Perkins, K. B., Seidler-Wulff, R., Banaszak, M. P. & Jacobs, B., Dec 22 1997, In : Virology. 239, 2, p. 269-276 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

Correction for Kibler et al., “Replication-competent NYVAC-KC yields improved immunogenicity to HIV-1 antigens in rhesus macaques compared to nonreplicating NYVAC”(J Virol 93, (e00968-19) DOI: 10.1128/JVI.01513-18)

Kibler, K. V., Asbach, B., Perdiguero, B., García-Arriaza, J., Yates, N. L., Parks, R., Stanfield-Oakley, S., Ferrari, G., Montefiori, D. C., Tomaras, G. D., Roederer, M., Foulds, K. E., Forthal, D. N., Seaman, M. S., Self, S., Gottardo, R., Phogat, S., Tartaglia, J., Barnett, S., Cristillo, A. D. & 8 others, Weiss, D., Galmin, L., Ding, S., Heeney, J. L., Esteban, M., Wagner, R., Pantaleo, G. & Jacobsa, B. L., Jan 1 2019, In : Journal of virology. 93, 21, e00968-19.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

CREB/ATF-dependent repression of cyclin A by human T-cell leukemia virus type 1 tax protein

Kibler, K. V. & Jeang, K. T., Feb 22 2001, In : Journal of virology. 75, 5, p. 2161-2173 13 p.

Research output: Contribution to journalArticle

45 Scopus citations

Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication

Hwang, S., Tamilarasu, N., Kibler, K., Cao, H., Ali, A., Ping, Y. H., Jeang, K. T. & Rana, T. M., Oct 3 2003, In : Journal of Biological Chemistry. 278, 40, p. 39092-39103 12 p.

Research output: Contribution to journalArticle

71 Scopus citations

Double-stranded RNA is a trigger for apoptosis in vaccinia virus- infected cells

Kibler, K., Shors, T., Perkins, K. B., Zeman, C. C., Banaszak, M. P., Biesterfeldt, J., Langland, J. & Jacobs, B., Mar 1 1997, In : Journal of virology. 71, 3, p. 1992-2003 12 p.

Research output: Contribution to journalArticle

166 Scopus citations

Effect of Hepatitis C Infection on HIV-Induced Apoptosis

Laskus, T., Kibler, K., Chmielewski, M., Wilkinson, J., Adair, D., Horban, A., Stańczak, G. & Radkowski, M., Oct 1 2013, In : PloS one. 8, 10, e75921.

Research output: Contribution to journalArticle

9 Scopus citations

Evasion of the innate immune type I interferon system by Monkeypox virus

Arndt, W. D., Cotsmire, S., Trainor, K., Harrington, H., Hauns, K., Kibler, K., Huynh, T. P. & Jacobs, B., 2015, In : Journal of Virology. 89, 20, p. 10489-10499 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Head-to-head comparison of poxvirus NYVAC and ALVAC vectors expressing identical HIV-1 clade C immunogens in prime-boost combination with Env protein in nonhuman primates

García-Arriaza, J., Perdiguero, B., Heeney, J., Seaman, M., Montefiori, D. C., Labranche, C., Yates, N. L., Shen, X., Tomaras, G. D., Ferrari, G., Foulds, K. E., McDermott, A., Kao, S. F., Roederer, M., Hawkins, N., Self, S., Yao, J., Farrell, P., Phogat, S., Tartaglia, J. & 12 others, Barnett, S. W., Burke, B., Cristillo, A., Weiss, D., Lee, C., Kibler, K., Jacobs, B., Asbach, B., Wagner, R., Ding, S., Pantaleo, G. & Esteban, M., Jan 1 2015, In : Journal of virology. 89, 16, p. 8525-8539 15 p.

Research output: Contribution to journalArticle

29 Scopus citations

Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation

Jin, D. Y., Wang, H. L., Zhou, Y., Chun, A. C. S., Kibler, K. V., Yun-De, H., Kung, H. F. & Jeang, K. T., Feb 15 2000, In : EMBO Journal. 19, 4, p. 729-740 12 p.

Research output: Contribution to journalArticle

118 Scopus citations

Hepatitis C virus quasi-species dynamics predict progression of fibrosis after liver transplantation

Arenas, J. I., Gallegos-Orozco, J. F., Laskus, T., Wilkinson, J., Khatib, A., Fasola, C., Adair, D., Radkowski, M., Kibler, K. V., Nowicki, M., Douglas, D., Williams, J., Netto, G., Mulligan, D., Klintmalm, G., Rakela, J. & Vargas, H. E., Apr 1 2004, In : Journal of Infectious Diseases. 189, 11, p. 2037-2046 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

HIV/AIDS vaccine candidates based on replication-competent recombinant poxvirus NYVAC-C-KC expressing trimeric gp140 and Gag-derived virus-like particles or lacking the viral molecule B19 that inhibits type I interferon activate relevant HIV-1-specific B and T cell immune functions in nonhuman primates

García-Arriaza, J., Perdiguero, B., Heeney, J. L., Seaman, M. S., Montefiori, D. C., Yates, N. L., Tomaras, G. D., Ferrari, G., Foulds, K. E., Roederer, M., Self, S. G., Borate, B., Gottardo, R., Phogat, S., Tartaglia, J., Barnett, S. W., Burke, B., Cristillo, A. D., Weiss, D. E., Lee, C. & 6 others, Kibler, K., Jacobs, B., Wagner, R., Ding, S., Pantaleo, G. & Esteban, M., May 1 2017, In : Journal of virology. 91, 9, e02182-16.

Research output: Contribution to journalArticle

15 Scopus citations

Human immunodeficiency virus facilitates infection/replication of hepatitis C virus in native human macrophages

Laskus, T., Radkowski, M., Jablonska, J., Kibler, K., Wilkinson, J., Adair, D. & Rakela, J., May 15 2004, In : Blood. 103, 10, p. 3854-3859 6 p.

Research output: Contribution to journalArticle

76 Scopus citations

Human T-cell leukemia virus type I: 25 Years of progress and challenges

Kibler, K. & Jeang, K. T., Jan 1 2005, In : Journal of Biomedical Science. 12, 1, p. 7-11 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Immunization of pigs by DNA prime and recombinant vaccinia virus boost to identify and rank African swine fever virus immunogenic and protective proteins

Jancovich, J. K., Chapman, D., Hansen, D., Robida, M. D., Loskutov, A., Craciunescu, F., Borovkov, A., Kibler, K., Goatley, L., King, K., Netherton, C. L., Taylor, G., Jacobs, B., Sykes, K. & Dixon, L. K., Apr 1 2018, In : Journal of Virology. 92, 8, e02219-17.

Research output: Contribution to journalArticle

17 Scopus citations

Immunogenicity of NYVAC primeprotein boost human immunodeficiency virus type 1 envelope vaccination and simianhuman immunodeficiency virus challenge of nonhuman primates

Saunders, K. O., Santra, S., Parks, R., Yates, N. L., Sutherland, L. L., Scearce, R. M., Balachandran, H., Bradley, T., Goodman, D., Eaton, A., Stanfield-Oakley, S. A., Tartaglia, J., Phogat, S., Pantaleo, G., Esteban, M., Gomez, C. E., Perdiguero, B., Jacobs, B., Kibler, K., Korber, B. & 6 others, Montefiori, D. C., Ferrari, G., Vandergrift, N., Liao, H. X., Tomaras, G. D. & Haynes, B. F., Apr 1 2018, In : Journal of virology. 92, 8, e02035-17.

Research output: Contribution to journalArticle

2 Scopus citations

Improved innate and adaptive immunostimulation by genetically modified HIV-1 protein expressing NYVAC vectors

Quakkelaar, E. D., Redeker, A., Haddad, E. K., Harari, A., McCaughey, S. M., Duhen, T., Filali-Mouhim, A., Goulet, J. P., Loof, N. M., Ossendorp, F., Perdiguero, B., Heinen, P., Gomez, C. E., Kibler, K., Koelle, D. M., Sékaly, R. P., Sallusto, F., Lanzavecchia, A., Pantaleo, G., Esteban, M. & 3 others, Tartaglia, J., Jacobs, B. & Melief, C. J. M., Feb 28 2011, In : PloS one. 6, 2, e16819.

Research output: Contribution to journalArticle

36 Scopus citations

Improved NYVAC-based vaccine vectors

Kibler, K., Gomez, C. E., Perdiguero, B., Wong, S., Huynh, T., Holechek, S., Arndt, W., Jimenez, V., Gonzalez-Sanz, R., Denzler, K., Haddad, E. K., Wagner, R., Sékaly, R. P., Tartaglia, J., Pantaleo, G., Jacobs, B. & Esteban, M., Nov 9 2011, In : PloS one. 6, 11, e25674.

Research output: Contribution to journalArticle

53 Scopus citations

Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3

Koehler, H., Cotsmire, S., Langland, J., Kibler, K., Kalman, D., Upton, J. W., Mocarski, E. S. & Jacobs, B., Oct 24 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 43, p. 11506-11511 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Monkeypox virus induces the synthesis of less dsRNA than vaccinia virus, and is more resistant to the anti-poxvirus drug, IBT, than vaccinia virus

Arndt, W. D., White, S. D., Johnson, B. P., Huynh, T., Liao, J., Harrington, H., Cotsmire, S., Kibler, K., Langland, J. & Jacobs, B., Oct 1 2016, In : Virology. 497, p. 125-135 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Pathogen reduction in human plasma using an ultrashort pulsed laser

Tsen, S. W. D., Kingsley, D. H., Kibler, K., Jacobs, B., Sizemore, S., Vaiana, S., Anderson, J., Tsen, K-T. & Achilefu, S., Nov 5 2014, In : PloS one. 9, 11, e111673.

Research output: Contribution to journalArticle

3 Scopus citations

Photonic approach to the selective inactivation of viruses with a near-infrared subpicosecond fiber laser

Tsen, K-T., Tsen, S. W. D., Fu, Q., Lindsay, S., Kibler, K., Jacobs, B., Wu, T. C., Karanam, B., Jagu, S., Roden, R. B. S., Hung, C. F., Sankey, O. F., Ramakrishna, B. & Kiang, J. G., Dec 1 2009, In : Journal of biomedical optics. 14, 6, 064042.

Research output: Contribution to journalArticle

24 Scopus citations

Pleiotropic effects of HTLV type 1 Tax protein on cellular metabolism: Mitotic checkpoint abrogation and NF-κB activation

Iha, H., Kasai, T., Kibler, K. V., Iwanaga, Y., Tsurugi, K. & Jeang, K. T., Nov 1 2000, In : AIDS Research and Human Retroviruses. 16, 16, p. 1633-1638 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Polyarginine inhibits gp160 processing by furin and suppresses productive human immunodeficiency virus type 1 infection

Kibler, K., Miyazato, A., Yedavalli, V. S. R. K., Dayton, A. I., Jacobs, B., Dapolito, G., Kim, S. J. & Jeang, K. T., Nov 19 2004, In : Journal of Biological Chemistry. 279, 47, p. 49055-49063 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Priming with a Potent HIV-1 DNA Vaccine Frames the Quality of Immune Responses prior to a Poxvirus and Protein Boost

Asbach, B., Kibler, K., Köstler, J., Perdiguero, B., Yates, N. L., Stanfield-Oakley, S., Tomaras, G. D., Kao, S. F., Foulds, K. E., Roederer, M., Seaman, M. S., Montefiori, D. C., Parks, R., Ferrari, G., Forthal, D. N., Phogat, S., Tartaglia, J., Barnett, S. W., Self, S. G., Gottardo, R. & 9 others, Cristillo, A. D., Weiss, D. E., Galmin, L., Ding, S., Heeney, J. L., Esteban, M., Jacobs, B., Pantaleo, G. & Wagner, R., Feb 1 2019, In : Journal of virology. 93, 3

Research output: Contribution to journalArticle

10 Scopus citations

Recombinant HIV-1 vaccine candidates based on replication-defective flavivirus vector

Giel-Moloney, M., Esteban, M., Oakes, B. H., Vaine, M., Asbach, B., Wagner, R., Mize, G. J., Spies, A. G., McElrath, J., Perreau, M., Roger, T., Ives, A., Calandra, T., Weiss, D., Perdiguero, B., Kibler, K. V., Jacobs, B., Ding, S., Tomaras, G. D., Montefiori, D. C. & 14 others, Ferrari, G., Yates, N. L., Roederer, M., Kao, S. F., Foulds, K. E., Mayer, B. T., Bennett, C., Gottardo, R., Parrington, M., Tartaglia, J., Phogat, S., Pantaleo, G., Kleanthous, H. & Pugachev, K. V., Dec 1 2019, In : Scientific reports. 9, 1, 20005.

Research output: Contribution to journalArticle

Open Access

Replication-Competent NYVAC-KC Yields Improved Immunogenicity to HIV-1 Antigens in Rhesus Macaques Compared to Nonreplicating NYVAC

Kibler, K., Asbach, B., Perdiguero, B., García-Arriaza, J., Yates, N. L., Parks, R., Stanfield-Oakley, S., Ferrari, G., Montefiori, D. C., Tomaras, G. D., Roederer, M., Foulds, K. E., Forthal, D. N., Seaman, M. S., Self, S., Gottardo, R., Phogat, S., Tartaglia, J., Barnett, S., Cristillo, A. D. & 8 others, Weiss, D., Galmin, L., Ding, S., Heeney, J. L., Esteban, M., Wagner, R., Pantaleo, G. & Jacobs, B., Feb 1 2019, In : Journal of virology. 93, 3

Research output: Contribution to journalArticle

5 Scopus citations

Role of adapter function in oncoprotein-mediated activation of NF-κB: Human T-cell leukemia virus type I Tax interacts directly with IκB kinase γ

Jin, D. Y., Giordano, V., Kibler, K. V., Nakano, H. & Jeang, K. T., Jun 18 1999, In : Journal of Biological Chemistry. 274, 25, p. 17402-17405 4 p.

Research output: Contribution to journalArticle

191 Scopus citations

Segregation of NF-κB activation through NEMO/IKKγ by Tax and TNFα: Implications for stimulus-specific interruption of oncogenic signaling

Iha, H., Kibler, K. V., Yedavalli, V. R. K., Peloponese, J. M., Haller, K., Miyazato, A., Kasai, T. & Jeang, K. T., Dec 4 2003, In : Oncogene. 22, 55, p. 8912-8923 12 p.

Research output: Contribution to journalArticle

55 Scopus citations

Selection of different 5′ untranslated region hepatitis C virus variants during post-transfusion and post-transplantation infection

Gallegos-Orozco, J. F., Arenas, J. I., Vargas, H. E., Kibler, K. V., Wilkinson, J. K., Nowicki, M., Radkowski, M., Nasseri, J., Rakela, J. & Laskus, T., Jul 1 2006, In : Journal of Viral Hepatitis. 13, 7, p. 489-498 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Selective Photonic Disinfection of Cell Culture Using a Visible Ultrashort Pulsed Laser

Tsen, S. W. D., Kibler, K., Jacobs, B., Fay, J. C., Podolnikova, N., Ugarova, T., Achilefu, S. & Tsen, K-T., May 1 2016, In : IEEE Journal on Selected Topics in Quantum Electronics. 22, 3, 7322185.

Research output: Contribution to journalArticle

3 Scopus citations

Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cells

Löhr, M., Kibler, K. V., Zachary, I., Jeang, K. T. & Selwood, D. L., Jan 10 2003, In : Biochemical and Biophysical Research Communications. 300, 2, p. 609-613 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Superiority in rhesus macaques of targeting HIV-1 Env gp140 to CD40 versus LOX-1 in combination with replication-competent NYVAC-KC for induction of Env-specific antibody and T cell responses

Zurawski, G., Shen, X., Zurawski, S., Tomaras, G. D., Montefiori, D. C., Roederer, M., Ferrari, G., Lacabaratz, C., Klucar, P., Wang, Z., Foulds, K. E., Kao, S. F., Yu, X., Sato, A., Yates, N. L., LaBranche, C., Stanfield-Oakley, S., Kibler, K., Jacobs, B., Salazar, A. & 8 others, Self, S., Fulp, W., Gottardo, R., Galmin, L., Weiss, D., Cristillo, A., Pantaleo, G. & Levy, Y., May 1 2017, In : Journal of virology. 91, 9, e01596-16.

Research output: Contribution to journalArticle

8 Scopus citations

Targeting HIV-1 env gp140 to LOX-1 elicits immune responses in rhesus macaques

Zurawski, G., Zurawski, S., Flamar, A. L., Richert, L., Wagner, R., Tomaras, G. D., Montefiori, D. C., Roederer, M., Ferrari, G., Lacabaratz, C., Bonnabau, H., Klucar, P., Wang, Z., Foulds, K. E., Kao, S. F., Yates, N. L., LaBranche, C., Jacobs, B., Kibler, K., Asbach, B. & 11 others, Kliche, A., Salazar, A., Reed, S., Self, S., Gottardo, R., Galmin, L., Weiss, D., Cristillo, A., Thiebaut, R., Pantaleo, G. & Levy, Y., Apr 2016, In : PloS one. 11, 4, e0153484.

Research output: Contribution to journalArticle

12 Scopus citations

The N-terminus of rodent and human MAD1 confers species-specific stringency to spindle assembly checkpoint

Haller, K., Kibler, K. V., Kasai, T., Chi, Y. H., Peloponese, J. M., Yedavalli, V. S. R. K. & Jeang, K. T., Apr 6 2006, In : Oncogene. 25, 15, p. 2137-2147 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: Scarification vaccination

Jentarra, G. M., Heck, M. C., Youn, J. W., Kibler, K., Langland, J., Baskin, C. R., Ananieva, O., Chang, Y. & Jacobs, B., Jun 2 2008, In : Vaccine. 26, 23, p. 2860-2872 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Virological and immunological characterization of novel NYVAC-Based HIV/AIDS vaccine candidates expressing clade C trimeric soluble gp140(ZM96) and Gag(ZM96)-Pol-Nef(CN54) as virus-like particles

Perdiguero, B., Gómez, C. E., Cepeda, V., Sánchez-Sampedro, L., García-Arriaza, J., Mejías-Pérez, E., Jiménez, V., Sánchez, C., Sorzano, C. Ó. S., Oliveros, J. C., Delaloye, J., Roger, T., Calandra, T., Asbach, B., Wagner, R., Kibler, K., Jacobs, B., Pantaleo, G. & Esteban, M., Jan 1 2015, In : Journal of virology. 89, 2, p. 970-988 19 p.

Research output: Contribution to journalArticle

20 Scopus citations