BI: Bioenergetics, Center for (BE)

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2000

Synthesis of aspartic acid derivatives useful for the preparation of misacylated transfer RNAs

Lodder, M., Crasto, C. F., Laikhter, A. L., An, H., Arslan, T., Karginov, V. A., Short, G. F. & Hecht, S. M., Jan 1 2000, In : Canadian Journal of Chemistry. 78, 6, p. 884-891 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
2001

Effect of 2′-5′ Phosphodiesters on DNA Transesterification by Vaccinia Topoisomerase

Krogh, B. O., Claeboe, C. D., Hecht, S. M. & Shuman, S., Jun 15 2001, In : Journal of Biological Chemistry. 276, 24, p. 20907-20912 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Metallobleomycin-mediated cleavage of DNA not involving a threading-intercalation mechanism

Abraham, A. T., Zhou, X. & Hecht, S. M., Oct 10 2001, In : Journal of the American Chemical Society. 123, 22, p. 5167-5175 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Photoactivated DNA cleavage by compounds structurally related to the bithiazole moiety of bleomycin

Quada, J. C., Boturyn, D. & Hecht, S. M., Jan 1 2001, In : Bioorganic and Medicinal Chemistry. 9, 9, p. 2303-2314 12 p.

Research output: Contribution to journalArticle

29 Scopus citations
21 Scopus citations

Studies toward the site specific incorporation of sugars into proteins: Synthesis of glycosylated aminoacyl-tRNAs

Fahmi, N. E., Golovine, S., Wang, B. & Hecht, S. M., Jan 30 2001, In : Carbohydrate Research. 330, 2, p. 149-164 16 p.

Research output: Contribution to journalArticle

17 Scopus citations

Synthesis and antibacterial activity of 3-hydroxy-6-O-methylerythromycin-9-O-substituted oxime derivatives

Chen, S. X., Xu, X. D. & Yu, L. X., Aug 1 2001, In : Yaoxue Xuebao. 36, 8, p. 583-584 2 p.

Research output: Contribution to journalArticle

Synthesis and DNA cleavage activity of a novel bleomycin A5 glycoconjugate

Choudhury, A. K., Tao, Z. F. & Hecht, S. M., May 3 2001, In : Organic Letters. 3, 9, p. 1291-1294 4 p.

Research output: Contribution to journalArticle

14 Scopus citations
2002

Design and optimization of camptothecin conjugates of triple helix-forming oligonucleotides for sequence-specific DNA cleavage by topoisomerase I

Arimondo, P. B., Boutorine, A., Baldeyrou, B., Bailly, C., Kuwahara, M., Hecht, S. M., Sun, J. S., Garestier, T. & Hélène, C., Feb 1 2002, In : Journal of Biological Chemistry. 277, 5, p. 3132-3140 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Fluorescence resonance energy transfer between unnatural amino acids in a structurally modified dihydrofolate reductase

Anderson, R. D., Zhou, J. & Hecht, S. M., Aug 21 2002, In : Journal of the American Chemical Society. 124, 33, p. 9674-9675 2 p.

Research output: Contribution to journalArticle

56 Scopus citations

Site-specific incorporation of (aminooxy)acetic acid into proteins

Eisenhauer, B. M. & Hecht, S. M., Sep 24 2002, In : Biochemistry. 41, 38, p. 11472-11478 7 p.

Research output: Contribution to journalArticle

29 Scopus citations
2003

A New Acylated Oleanane Triterpenoid from Couepia polyandra that Inhibits the Lyase Activity of DNA Polymerase β

Prakash Chaturvedula, V. S., Gao, Z., Hecht, S. M., Jones, S. H. & Kingston, D. G. I., Nov 1 2003, In : Journal of Natural Products. 66, 11, p. 1463-1465 3 p.

Research output: Contribution to journalArticle

27 Scopus citations

Conformationally constrained analogues of bleomycin A5

Rishel, M. J., Thomas, C. J., Tao, Z. F., Vialas, C., Leitheiser, C. J. & Hecht, S. M., Aug 27 2003, In : Journal of the American Chemical Society. 125, 34, p. 10194-10205 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Guarding the genome: Electrostatic repulsion of water by DNA suppresses a potent nuclease activity of topoisomerase IB

Tian, L., Claeboe, C. D., Hecht, S. M. & Shuman, S., Jul 1 2003, In : Molecular Cell. 12, 1, p. 199-208 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Inhibitors of the lyase activity of DNA polymerase β

Hecht, S. M., Dec 1 2003, In : Pharmaceutical Biology. 41, SUPPL., p. 68-77 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Luotonin A. A Naturally Occurring Human DNA Topoisomerase I Poison

Cagir, A., Jones, S. H., Gao, R., Eisenhauer, B. M. & Hecht, S. M., Nov 12 2003, In : Journal of the American Chemical Society. 125, 45, p. 13628-13629 2 p.

Research output: Contribution to journalArticle

183 Scopus citations

RNA cleavage and inhibition of protein synthesis by Bleomycin

Abraham, A. T., Lin, J. J., Newton, D. L., Rybak, S. & Hecht, S. M., Jan 1 2003, In : Chemistry and Biology. 10, 1, p. 45-52 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Solid-phase synthesis of bleomycin group antibiotics. Construction of a 108-member deglycobleomycin library

Leitheiser, C. J., Smith, K. L., Rishel, M. J., Hashimoto, S., Konishi, K., Thomas, C. J., Li, C., McCormick, M. M. & Hecht, S. M., Jul 9 2003, In : Journal of the American Chemical Society. 125, 27, p. 8218-8227 10 p.

Research output: Contribution to journalArticle

47 Scopus citations
2004

A DNA-damaging oxoaporphine alkaloid from Piper caninum

Ma, J., Jones, S. H., Marshall, R., Johnson, R. K. & Hecht, S. M., Jul 1 2004, In : Journal of Natural Products. 67, 7, p. 1162-1164 3 p.

Research output: Contribution to journalArticle

19 Scopus citations

A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase β lyase

Chaturvedula, V. S. P., Gao, Z., Jones, S. H., Feng, X., Hecht, S. M. & Kingston, D. G. I., May 1 2004, In : Journal of Natural Products. 67, 5, p. 899-901 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

Biscoumarin derivatives from Edgeworthia gardneri that inhibit the lyase activity of DNA polymerase β

Li, S. S., Gao, Z., Feng, X. & Hecht, S. M., Sep 1 2004, In : Journal of Natural Products. 67, 9, p. 1608-1610 3 p.

Research output: Contribution to journalArticle

28 Scopus citations

New norditerpenoids and a diterpenoid from a sponge that inhibit the lyase activity of DNA polymerase β

Chaturvedula, V. S. P., Gao, Z., Thomas, S. H., Hecht, S. M. & Kingston, D. G. I., Oct 25 2004, In : Tetrahedron. 60, 44, p. 9991-9995 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Plant sterols as selective DNA polymerase β lyase inhibitors and potentiators of bleomycin cytotoxicity

Li, S. S., Gao, Z., Feng, X., Jones, S. H. & Hecht, S. M., Aug 1 2004, In : Bioorganic and Medicinal Chemistry. 12, 15, p. 4253-4258 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Remote Phosphate Contacts Trigger Assembly of the Active Site of DNA Topoisomerase IB

Tian, L., Claeboe, C. D., Hecht, S. M. & Shuman, S., Jan 2004, In : Structure. 12, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Site- and subunit-specific incorporation of unnatural amino acids into HIV-1 reverse transcriptase

Klarmann, G. J., Eisenhauer, B. M., Zhang, Y., Sitaraman, K., Chatterjee, D. K., Hecht, S. M. & Le Grice, S. F. J., Nov 1 2004, In : Protein Expression and Purification. 38, 1, p. 37-44 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Synthesis and biochemical properties of E-ring modified luotonin a derivatives

Cagir, A., Jones, S. H., Eisenhauer, B. M., Gao, R. & Hecht, S. M., May 3 2004, In : Bioorganic and Medicinal Chemistry Letters. 14, 9, p. 2051-2054 4 p.

Research output: Contribution to journalArticle

49 Scopus citations

Synthesis and in vitro antibacterial activity of 7-[(2s)-2-amino methyl-pyrrolidine-1-yl]-quinolone derivatives

Chen, S. X. & Guo, H. Y., Sep 23 2004, In : Chinese Journal of Antibiotics. 29, 7, p. 397-400+422

Research output: Contribution to journalArticle

1 Scopus citations
2005

(+)-Myristinin A, a naturally occurring DNA polymerase β inhibitor and potent DNA-damaging agent

Maloney, D. J., Deng, J. Z., Starck, S. R., Gao, Z. & Hecht, S. M., Mar 30 2005, In : Journal of the American Chemical Society. 127, 12, p. 4140-4141 2 p.

Research output: Contribution to journalArticle

70 Scopus citations

A dihydroflavonol glucoside from Commiphora africana that mediates DNA strand scission

Ma, J., Jones, S. H. & Hecht, S. M., Jan 1 2005, In : Journal of Natural Products. 68, 1, p. 115-117 3 p.

Research output: Contribution to journalArticle

14 Scopus citations

Alkaloids from Alangium javanicum and Alangium grisolleoides that mediate Cu2+-dependent DNA strand scission

Pham, V. C., Ma, J., Thomas, S. J., Xu, Z. & Hecht, S. M., Aug 1 2005, In : Journal of Natural Products. 68, 8, p. 1147-1152 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

DNA topoisomerase I inhibitors from Rinorea anguifera

Ma, J., Jones, S. H., Marshall, R., Wu, X. & Hecht, S. M., Feb 1 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 3, p. 813-816 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Mechanistic plasticity of DNA topoisomerase IB: Phosphate electrostatics dictate the need for a catalytic arginine

Tian, L., Claeboe, C. D., Hecht, S. M. & Shuman, S., Apr 2005, In : Structure. 13, 4, p. 513-520 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Synthesis of a potent and selective inhibitor of p90 Rsk

Maloney, D. J. & Hecht, S. M., Mar 17 2005, In : Organic Letters. 7, 6, p. 1097-1099 3 p.

Research output: Contribution to journalArticle

55 Scopus citations

The N-pentenoyl protecting group for aminoacyl-tRNAs

Lodder, M., Wang, B. & Hecht, S. M., Jul 1 2005, In : Methods. 36, 3, p. 245-251 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Umbelactonyl cinnamate derivatives from Crypteronia paniculata that mediate DNA strand scission

Deng, J. Z., Newman, D. J. & Hecht, S. M., Mar 1 2005, In : Journal of Natural Products. 68, 3, p. 465-467 3 p.

Research output: Contribution to journalArticle

5 Scopus citations
2006

An efficient mammalian transfer RNA target for bleomycin

Tao, Z. F., Konishi, K., Keith, G. & Hecht, S. M., Nov 22 2006, In : Journal of the American Chemical Society. 128, 46, p. 14806-14807 2 p.

Research output: Contribution to journalArticle

19 Scopus citations

Bioactive isomalabaricane triterpenoids from Rhabdastrella globostellata that stabilize the binding of DNA polymerase β to DNA

Clement, J. A., Li, M., Hecht, S. M. & Kingston, D. G. I., Mar 1 2006, In : Journal of Natural Products. 69, 3, p. 373-376 4 p.

Research output: Contribution to journalArticle

26 Scopus citations

Construction of modified ribosomes for incorporation of D-amino acids into proteins

Dedkova, L. M., Fahmi, N. E., Golovine, S. Y. & Hecht, S. M., Dec 26 2006, In : Biochemistry. 45, 51, p. 15541-15551 11 p.

Research output: Contribution to journalArticle

49 Scopus citations

Design of a cyclopropyl quinone methide reductive alkylating agent. 2

Khdour, O., Ouyang, A. & Skibo, E. B., Aug 1 2006, In : Journal of Organic Chemistry. 71, 16, p. 5855-5863 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Exploring the cellular activity of camptothecin-triple-helix-forming oligonucleotide conjugates

Arimondo, P. B., Thomas, C. J., Oussedik, K., Baldeyrou, B., Mahieu, C., Halby, L., Guianvarc'h, D., Lansiaux, A., Hecht, S. M., Bailly, C. & Giovannangeli, C., Jan 1 2006, In : Molecular and cellular biology. 26, 1, p. 324-333 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK

Smith, J. A., Maloney, D. J., Clark, D. E., Xu, Y., Hecht, S. M. & Lannigan, D. A., Sep 1 2006, In : Bioorganic and Medicinal Chemistry. 14, 17, p. 6034-6042 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Stereoselective synthesis of the atropisomers of myristinin B/C

Maloney, D. J., Chen, S. & Hecht, S. M., Apr 27 2006, In : Organic Letters. 8, 9, p. 1925-1927 3 p.

Research output: Contribution to journalArticle

19 Scopus citations

Synthesis and biological evaluation of 10,11-methylenedioxy-14- azacamptothecin

Elban, M. A., Sun, W., Eisenhauer, B. M., Gao, R. & Hecht, S. M., Aug 3 2006, In : Organic Letters. 8, 16, p. 3513-3516 4 p.

Research output: Contribution to journalArticle

28 Scopus citations
2007

Biochemical evaluation of a 108-member deglycobleomycin library: Viability of a selection strategy for identifying bleomycin analogues with altered properties

Ma, Q., Xu, Z., Schroeder, B. R., Sun, W., Wei, F., Hashimoto, S., Konishi, K., Leitheiser, C. J. & Hecht, S. M., Oct 17 2007, In : Journal of the American Chemical Society. 129, 41, p. 12439-12452 14 p.

Research output: Contribution to journalArticle

21 Scopus citations
16 Scopus citations

Effect of metal doping on the low-temperature structural behavior of thermoelectric β-Zn4Sb3

Nylén, J., Lidin, S., Andersson, M., Liu, H., Newman, N. & Häussermann, U., Sep 1 2007, In : Journal of Solid State Chemistry. 180, 9, p. 2603-2615 13 p.

Research output: Contribution to journalArticle

54 Scopus citations

Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines

Elban, M. A., Chapuis, J., Li, M. & Hecht, S., Sep 15 2007, In : Bioorganic and Medicinal Chemistry. 15, 18, p. 6119-6125 7 p.

Research output: Contribution to journalArticle

7 Scopus citations
2008

A novel technique for synthesizing MgB2 thin films with high upper critical fields

Shen, Y., Gandikota, R., Singh, R., Hunte, F. L., Jaroszynski, J., Larbalestier, D. C., Rowell, J. M. & Newman, N., Aug 1 2008, In : Superconductor Science and Technology. 21, 8, 085009.

Research output: Contribution to journalArticle

9 Scopus citations

Composition modulations in Al0.4 Ga0.6 N layers grown by molecular beam epitaxy

Wise, A., Nandivada, R., Strawbridge, B., Carpenter, R., Newman, N. & Mahajan, S., Jul 11 2008, In : Applied Physics Letters. 92, 26, 261914.

Research output: Contribution to journalArticle

8 Scopus citations

Effect of oxygen incorporation on normal and superconducting properties of MgB2 films

Singh, R., Shen, Y., Gandikota, R., Carvalho, C., Rowell, J. M. & Newman, N., Dec 29 2008, In : Applied Physics Letters. 93, 24, 242504.

Research output: Contribution to journalArticle

10 Scopus citations