Yatapoxviruses

J. W. Barrett, G. McFadden

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The genus Yatapoxvirus includes two members: yaba monkey tumor virus (YMTV), the type species, and tanapox virus (TPV). These viruses are primate specific and of African origin. YMTV infects monkeys naturally and humans only by accident or injection. TPV infects humans, and a strain of TPV, called yaba-like disease virus (YLDV), has been isolated from primates and their handlers in primate centers. The genomes of the known Yatapoxvirus members have all been sequenced and are among the smallest poxvirus genomes known: 134.7 kbp (YMTV) and 144.6 kbp (TPV/YLDV). YMTV and TPV share the genomic features of other poxviruses, including terminal inverted repeats at the ends of their linear double-stranded genomes and an A+T-rich (70-73%) sequence. YMTV infection of rhesus monkeys produces subcutaneous tumors that are composed of histiocytes, which actively divide and become spindle shaped. These large histiocytomas naturally regress over several months. TPV infection involves a short febrile illness followed by the appearance and development of individual, hard, raised nodules that regress after 3-4 weeks. Transmission of the yatapoxviruses is most likely via bite from an arthropod vector (mosquito), but their reservoir host species remains unknown.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Virology
PublisherElsevier Ltd
Pages461-465
Number of pages5
ISBN (Print)9780123744104
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Fingerprint

Yatapoxvirus
Yaba monkey tumor virus
Virus Diseases
Primates
Poxviridae
Genome
Tumor Virus Infections
Histiocytoma
Arthropod Vectors
Histiocytes
Terminal Repeat Sequences
Bites and Stings
Culicidae
Macaca mulatta
Haplorhini

Keywords

  • African origin
  • Chordopoxvirus
  • Histiocytomas
  • Primate poxviruses

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Barrett, J. W., & McFadden, G. (2008). Yatapoxviruses. In Encyclopedia of Virology (pp. 461-465). Elsevier Ltd. https://doi.org/10.1016/B978-012374410-4.00455-6

Yatapoxviruses. / Barrett, J. W.; McFadden, G.

Encyclopedia of Virology. Elsevier Ltd, 2008. p. 461-465.

Research output: Chapter in Book/Report/Conference proceedingChapter

Barrett, JW & McFadden, G 2008, Yatapoxviruses. in Encyclopedia of Virology. Elsevier Ltd, pp. 461-465. https://doi.org/10.1016/B978-012374410-4.00455-6
Barrett JW, McFadden G. Yatapoxviruses. In Encyclopedia of Virology. Elsevier Ltd. 2008. p. 461-465 https://doi.org/10.1016/B978-012374410-4.00455-6
Barrett, J. W. ; McFadden, G. / Yatapoxviruses. Encyclopedia of Virology. Elsevier Ltd, 2008. pp. 461-465
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