Wrinkle cellomics

Screening bladder cancer cells using an ultra-thin silicone membrane

Jennie Appel, Mandy L Y Sin, Joseph C. Liao, Junseok Chae

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We report a visualization platform, comprised of an ultra-thin silicone membrane, to differentiate between the biophysical properties of cancerous and non-cancerous cells from human patients. Cancerous cells adhere to, spread on, and induce deformation of this membrane to produce wrinkles while non-cancerous cells fail to generate wrinkles. Wrinkle patterns-number, length, and direction of wrinkles-can be visualized by a conventional microscopy. Quantitative measurement of these wrinkling patterns represent a powerful, non-invasive diagnostic tool for prevalent cancers, such as bladder cancer.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages889-892
Number of pages4
ISBN (Print)9781479935086
DOIs
StatePublished - 2014
Event27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014 - San Francisco, CA, United States
Duration: Jan 26 2014Jan 30 2014

Other

Other27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014
CountryUnited States
CitySan Francisco, CA
Period1/26/141/30/14

Fingerprint

bladder
silicones
Silicones
Screening
screening
cancer
Cells
membranes
Membranes
cells
wrinkling
Microscopic examination
Visualization
platforms
microscopy
Direction compound

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

Appel, J., Sin, M. L. Y., Liao, J. C., & Chae, J. (2014). Wrinkle cellomics: Screening bladder cancer cells using an ultra-thin silicone membrane. In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) (pp. 889-892). [6765784] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMSYS.2014.6765784

Wrinkle cellomics : Screening bladder cancer cells using an ultra-thin silicone membrane. / Appel, Jennie; Sin, Mandy L Y; Liao, Joseph C.; Chae, Junseok.

Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). Institute of Electrical and Electronics Engineers Inc., 2014. p. 889-892 6765784.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Appel, J, Sin, MLY, Liao, JC & Chae, J 2014, Wrinkle cellomics: Screening bladder cancer cells using an ultra-thin silicone membrane. in Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)., 6765784, Institute of Electrical and Electronics Engineers Inc., pp. 889-892, 27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014, San Francisco, CA, United States, 1/26/14. https://doi.org/10.1109/MEMSYS.2014.6765784
Appel J, Sin MLY, Liao JC, Chae J. Wrinkle cellomics: Screening bladder cancer cells using an ultra-thin silicone membrane. In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). Institute of Electrical and Electronics Engineers Inc. 2014. p. 889-892. 6765784 https://doi.org/10.1109/MEMSYS.2014.6765784
Appel, Jennie ; Sin, Mandy L Y ; Liao, Joseph C. ; Chae, Junseok. / Wrinkle cellomics : Screening bladder cancer cells using an ultra-thin silicone membrane. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). Institute of Electrical and Electronics Engineers Inc., 2014. pp. 889-892
@inproceedings{b428aefb7aab40d9a26d9b5095e823c1,
title = "Wrinkle cellomics: Screening bladder cancer cells using an ultra-thin silicone membrane",
abstract = "We report a visualization platform, comprised of an ultra-thin silicone membrane, to differentiate between the biophysical properties of cancerous and non-cancerous cells from human patients. Cancerous cells adhere to, spread on, and induce deformation of this membrane to produce wrinkles while non-cancerous cells fail to generate wrinkles. Wrinkle patterns-number, length, and direction of wrinkles-can be visualized by a conventional microscopy. Quantitative measurement of these wrinkling patterns represent a powerful, non-invasive diagnostic tool for prevalent cancers, such as bladder cancer.",
author = "Jennie Appel and Sin, {Mandy L Y} and Liao, {Joseph C.} and Junseok Chae",
year = "2014",
doi = "10.1109/MEMSYS.2014.6765784",
language = "English (US)",
isbn = "9781479935086",
pages = "889--892",
booktitle = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",
publisher = "Institute of Electrical and Electronics Engineers Inc.",

}

TY - GEN

T1 - Wrinkle cellomics

T2 - Screening bladder cancer cells using an ultra-thin silicone membrane

AU - Appel, Jennie

AU - Sin, Mandy L Y

AU - Liao, Joseph C.

AU - Chae, Junseok

PY - 2014

Y1 - 2014

N2 - We report a visualization platform, comprised of an ultra-thin silicone membrane, to differentiate between the biophysical properties of cancerous and non-cancerous cells from human patients. Cancerous cells adhere to, spread on, and induce deformation of this membrane to produce wrinkles while non-cancerous cells fail to generate wrinkles. Wrinkle patterns-number, length, and direction of wrinkles-can be visualized by a conventional microscopy. Quantitative measurement of these wrinkling patterns represent a powerful, non-invasive diagnostic tool for prevalent cancers, such as bladder cancer.

AB - We report a visualization platform, comprised of an ultra-thin silicone membrane, to differentiate between the biophysical properties of cancerous and non-cancerous cells from human patients. Cancerous cells adhere to, spread on, and induce deformation of this membrane to produce wrinkles while non-cancerous cells fail to generate wrinkles. Wrinkle patterns-number, length, and direction of wrinkles-can be visualized by a conventional microscopy. Quantitative measurement of these wrinkling patterns represent a powerful, non-invasive diagnostic tool for prevalent cancers, such as bladder cancer.

UR - http://www.scopus.com/inward/record.url?scp=84898951611&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898951611&partnerID=8YFLogxK

U2 - 10.1109/MEMSYS.2014.6765784

DO - 10.1109/MEMSYS.2014.6765784

M3 - Conference contribution

SN - 9781479935086

SP - 889

EP - 892

BT - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

PB - Institute of Electrical and Electronics Engineers Inc.

ER -