Wrinkle cellomics: Screening bladder cancer cells using an ultra-thin silicone membrane

Jennie Appel, Mandy L Y Sin, Joseph C. Liao, Junseok Chae

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

We report a visualization platform, comprised of an ultra-thin silicone membrane, to differentiate between the biophysical properties of cancerous and non-cancerous cells from human patients. Cancerous cells adhere to, spread on, and induce deformation of this membrane to produce wrinkles while non-cancerous cells fail to generate wrinkles. Wrinkle patterns-number, length, and direction of wrinkles-can be visualized by a conventional microscopy. Quantitative measurement of these wrinkling patterns represent a powerful, non-invasive diagnostic tool for prevalent cancers, such as bladder cancer.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages889-892
Number of pages4
ISBN (Print)9781479935086
DOIs
Publication statusPublished - 2014
Event27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014 - San Francisco, CA, United States
Duration: Jan 26 2014Jan 30 2014

Other

Other27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014
CountryUnited States
CitySan Francisco, CA
Period1/26/141/30/14

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ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

Appel, J., Sin, M. L. Y., Liao, J. C., & Chae, J. (2014). Wrinkle cellomics: Screening bladder cancer cells using an ultra-thin silicone membrane. In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) (pp. 889-892). [6765784] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMSYS.2014.6765784