TY - GEN
T1 - Wrinkle cellomics
T2 - 27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014
AU - Appel, Jennie
AU - Sin, Mandy L Y
AU - Liao, Joseph C.
AU - Chae, Junseok
PY - 2014/1/1
Y1 - 2014/1/1
N2 - We report a visualization platform, comprised of an ultra-thin silicone membrane, to differentiate between the biophysical properties of cancerous and non-cancerous cells from human patients. Cancerous cells adhere to, spread on, and induce deformation of this membrane to produce wrinkles while non-cancerous cells fail to generate wrinkles. Wrinkle patterns-number, length, and direction of wrinkles-can be visualized by a conventional microscopy. Quantitative measurement of these wrinkling patterns represent a powerful, non-invasive diagnostic tool for prevalent cancers, such as bladder cancer.
AB - We report a visualization platform, comprised of an ultra-thin silicone membrane, to differentiate between the biophysical properties of cancerous and non-cancerous cells from human patients. Cancerous cells adhere to, spread on, and induce deformation of this membrane to produce wrinkles while non-cancerous cells fail to generate wrinkles. Wrinkle patterns-number, length, and direction of wrinkles-can be visualized by a conventional microscopy. Quantitative measurement of these wrinkling patterns represent a powerful, non-invasive diagnostic tool for prevalent cancers, such as bladder cancer.
UR - http://www.scopus.com/inward/record.url?scp=84898951611&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84898951611&partnerID=8YFLogxK
U2 - 10.1109/MEMSYS.2014.6765784
DO - 10.1109/MEMSYS.2014.6765784
M3 - Conference contribution
AN - SCOPUS:84898951611
SN - 9781479935086
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 889
EP - 892
BT - MEMS 2014 - 27th IEEE International Conference on Micro Electro Mechanical Systems
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 26 January 2014 through 30 January 2014
ER -