Within Host Dynamical Immune Response to Co-infection with Malaria and Tuberculosis

Edme Soho, Stephen Wirkus

Research output: Chapter in Book/Report/Conference proceedingChapter


Diseases have been part of human life for generations and evolve within the population, sometimes dying out while other times becoming endemic or the cause of recurrent outbreaks. Co-infection with different pathogens is common, yet little is known about how infection with one pathogen affects the host’s immunological response to another. Immunology-based models of malaria and tuberculosis (TB) are constructed by extending and modifying existing mathematical models in the literature. The two are then combined to give a single nine-variable model of co-infection with malaria and TB. The immunology-based models of malaria and TB give numerical results that agree with the biological observations. The malaria–TB co-infection model gives reasonable results and these suggest that the order in which the two diseases are introduced have an impact on the behavior of both.

Original languageEnglish (US)
Title of host publicationSTEAM-H
Subtitle of host publicationScience, Technology, Engineering, Agriculture, Mathematics and Health
PublisherSpringer Nature
Number of pages21
StatePublished - 2019

Publication series

NameSTEAM-H: Science, Technology, Engineering, Agriculture, Mathematics and Health
ISSN (Print)2520-193X
ISSN (Electronic)2520-1948


  • Co-infection
  • Malaria
  • Math models
  • Tuberculosis

ASJC Scopus subject areas

  • Applied Mathematics
  • Modeling and Simulation
  • Agricultural and Biological Sciences(all)
  • Engineering(all)
  • Medicine(all)
  • Computer Science(all)
  • Chemistry(all)
  • Economics, Econometrics and Finance(all)


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