Wireless passive stimulation of engineered cardiac tissues

Shiyi Liu; Ali Navaei; Xueling Meng; Mehdi Nikkhah; Junseok Chae

doi:10.1021/acssensors.7b00279

Wireless passive stimulation of engineered cardiac tissues

Shiyi Liu, Ali Navaei, Xueling Meng, Mehdi Nikkhah, Junseok Chae

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We present a battery-free radio frequency (RF) microwave activated wireless stimulator, 25 × 42 × 1.6 mm³ on a flexible substrate, featuring high current delivery, up to 60 mA, to stimulate engineered cardiac tissues. An external antenna shines 2.4 GHz microwave, which is modulated by an inverted pulse to directly control the stimulating waveform, to the wireless passive stimulator. The stimulator is equipped with an on-board antenna, multistage diode multipliers, and a control transistor. Rat cardiomyocytes, seeded on electrically conductive gelatin-based hydrogels, demonstrate synchronous contractions and Ca²⁺ transients immediately upon stimulation. Notably, the stimulator output voltage and current profiles match the tissue contraction frequency within 0.5-2 Hz. Overall, our results indicate the promising potential of the proposed wireless passive stimulator for cardiac stimulation and therapy by induction of precisely controlled and synchronous contractions.

Original language	English (US)
Pages (from-to)	1006-1012
Number of pages	7
Journal	ACS sensors
Volume	2
Issue number	7
DOIs	https://doi.org/10.1021/acssensors.7b00279
State	Published - Jul 28 2017

Keywords

Cardiac tissue
Contraction
Implant
Passive
Wireless stimulator

ASJC Scopus subject areas

Bioengineering
Instrumentation
Process Chemistry and Technology
Fluid Flow and Transfer Processes

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10.1021/acssensors.7b00279

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title = "Wireless passive stimulation of engineered cardiac tissues",

abstract = "We present a battery-free radio frequency (RF) microwave activated wireless stimulator, 25 × 42 × 1.6 mm3 on a flexible substrate, featuring high current delivery, up to 60 mA, to stimulate engineered cardiac tissues. An external antenna shines 2.4 GHz microwave, which is modulated by an inverted pulse to directly control the stimulating waveform, to the wireless passive stimulator. The stimulator is equipped with an on-board antenna, multistage diode multipliers, and a control transistor. Rat cardiomyocytes, seeded on electrically conductive gelatin-based hydrogels, demonstrate synchronous contractions and Ca2+ transients immediately upon stimulation. Notably, the stimulator output voltage and current profiles match the tissue contraction frequency within 0.5-2 Hz. Overall, our results indicate the promising potential of the proposed wireless passive stimulator for cardiac stimulation and therapy by induction of precisely controlled and synchronous contractions.",

keywords = "Cardiac tissue, Contraction, Implant, Passive, Wireless stimulator",

author = "Shiyi Liu and Ali Navaei and Xueling Meng and Mehdi Nikkhah and Junseok Chae",

note = "Funding Information: This work is partly supported by National Science Foundation, #1344928. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

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doi = "10.1021/acssensors.7b00279",

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AU - Liu, Shiyi

AU - Navaei, Ali

AU - Meng, Xueling

AU - Nikkhah, Mehdi

AU - Chae, Junseok

PY - 2017/7/28

Y1 - 2017/7/28

N2 - We present a battery-free radio frequency (RF) microwave activated wireless stimulator, 25 × 42 × 1.6 mm3 on a flexible substrate, featuring high current delivery, up to 60 mA, to stimulate engineered cardiac tissues. An external antenna shines 2.4 GHz microwave, which is modulated by an inverted pulse to directly control the stimulating waveform, to the wireless passive stimulator. The stimulator is equipped with an on-board antenna, multistage diode multipliers, and a control transistor. Rat cardiomyocytes, seeded on electrically conductive gelatin-based hydrogels, demonstrate synchronous contractions and Ca2+ transients immediately upon stimulation. Notably, the stimulator output voltage and current profiles match the tissue contraction frequency within 0.5-2 Hz. Overall, our results indicate the promising potential of the proposed wireless passive stimulator for cardiac stimulation and therapy by induction of precisely controlled and synchronous contractions.

AB - We present a battery-free radio frequency (RF) microwave activated wireless stimulator, 25 × 42 × 1.6 mm3 on a flexible substrate, featuring high current delivery, up to 60 mA, to stimulate engineered cardiac tissues. An external antenna shines 2.4 GHz microwave, which is modulated by an inverted pulse to directly control the stimulating waveform, to the wireless passive stimulator. The stimulator is equipped with an on-board antenna, multistage diode multipliers, and a control transistor. Rat cardiomyocytes, seeded on electrically conductive gelatin-based hydrogels, demonstrate synchronous contractions and Ca2+ transients immediately upon stimulation. Notably, the stimulator output voltage and current profiles match the tissue contraction frequency within 0.5-2 Hz. Overall, our results indicate the promising potential of the proposed wireless passive stimulator for cardiac stimulation and therapy by induction of precisely controlled and synchronous contractions.

KW - Cardiac tissue

KW - Contraction

KW - Implant

KW - Passive

KW - Wireless stimulator

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Wireless passive stimulation of engineered cardiac tissues

Abstract

Keywords

ASJC Scopus subject areas

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