Wireless microstimulators for treatment of peripheral vascular disease

Bruce C. Towe, Taylor Graber, Daniel Gulick, Richard Herman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Electrical stimulation of the rat sciatic nerve for the potential treatment of peripheral vascular disease was investigated using a chronically implanted millimeter-wide ultrasound-powered neurostimulator. The implanted device was sufficiently small as to pass through a 15 Ga syringe needle and produce as much as 25% increases in blood flow in a normal rat. The neurostimulator was powered by pulsed 500 kHz ultrasound applied to the rat skin over the implant at safe power levels on the order of 10-100 mW/cm2. Vasodilation was produced using pulse amplitudes just below that needed to evoke rat hindlimb motor response and at widths of 1 ms and frequency of 3 Hz for 5 periods of 30s with 120s of resting time. The results using a laser Doppler flowmetry system showed the neurostimulator to be an effective and wireless method of increasing peripheral blood flow in the rat hindlimb.

Original languageEnglish (US)
Title of host publication2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013
Pages1485-1488
Number of pages4
DOIs
StatePublished - Dec 1 2013
Event2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013 - San Diego, CA, United States
Duration: Nov 6 2013Nov 8 2013

Publication series

NameInternational IEEE/EMBS Conference on Neural Engineering, NER
ISSN (Print)1948-3546
ISSN (Electronic)1948-3554

Other

Other2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013
CountryUnited States
CitySan Diego, CA
Period11/6/1311/8/13

    Fingerprint

ASJC Scopus subject areas

  • Artificial Intelligence
  • Mechanical Engineering

Cite this

Towe, B. C., Graber, T., Gulick, D., & Herman, R. (2013). Wireless microstimulators for treatment of peripheral vascular disease. In 2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013 (pp. 1485-1488). [6696226] (International IEEE/EMBS Conference on Neural Engineering, NER). https://doi.org/10.1109/NER.2013.6696226