TY - GEN
T1 - Wireless microstimulators for treatment of peripheral vascular disease
AU - Towe, Bruce C.
AU - Graber, Taylor
AU - Gulick, Daniel
AU - Herman, Richard
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - Electrical stimulation of the rat sciatic nerve for the potential treatment of peripheral vascular disease was investigated using a chronically implanted millimeter-wide ultrasound-powered neurostimulator. The implanted device was sufficiently small as to pass through a 15 Ga syringe needle and produce as much as 25% increases in blood flow in a normal rat. The neurostimulator was powered by pulsed 500 kHz ultrasound applied to the rat skin over the implant at safe power levels on the order of 10-100 mW/cm2. Vasodilation was produced using pulse amplitudes just below that needed to evoke rat hindlimb motor response and at widths of 1 ms and frequency of 3 Hz for 5 periods of 30s with 120s of resting time. The results using a laser Doppler flowmetry system showed the neurostimulator to be an effective and wireless method of increasing peripheral blood flow in the rat hindlimb.
AB - Electrical stimulation of the rat sciatic nerve for the potential treatment of peripheral vascular disease was investigated using a chronically implanted millimeter-wide ultrasound-powered neurostimulator. The implanted device was sufficiently small as to pass through a 15 Ga syringe needle and produce as much as 25% increases in blood flow in a normal rat. The neurostimulator was powered by pulsed 500 kHz ultrasound applied to the rat skin over the implant at safe power levels on the order of 10-100 mW/cm2. Vasodilation was produced using pulse amplitudes just below that needed to evoke rat hindlimb motor response and at widths of 1 ms and frequency of 3 Hz for 5 periods of 30s with 120s of resting time. The results using a laser Doppler flowmetry system showed the neurostimulator to be an effective and wireless method of increasing peripheral blood flow in the rat hindlimb.
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U2 - 10.1109/NER.2013.6696226
DO - 10.1109/NER.2013.6696226
M3 - Conference contribution
AN - SCOPUS:84897729929
SN - 9781467319690
T3 - International IEEE/EMBS Conference on Neural Engineering, NER
SP - 1485
EP - 1488
BT - 2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013
T2 - 2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013
Y2 - 6 November 2013 through 8 November 2013
ER -