Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary history

Xuming Zhou; Boshi Wang; Qi Pan; Jinbo Zhang; Sudhir Kumar; Xiaoqing Sun; Zhijin Liu; Huijuan Pan; Yu Lin; Guangjian Liu; Wei Zhan; Mangzhou Li; Baoping Ren; Xingyong Ma; Hang Ruan; Chen Cheng; Dawei Wang; Fanglei Shi; Yuanyuan Hui; Yujing Tao; Chenglin Zhang; Pingfen Zhu; Zuofu Xiang; Wenkai Jiang; Jiang Chang; Hailong Wang; Zhisheng Cao; Zhi Jiang; Baoguo Li; Guang Yang; Christian Roos; Paul A. Garber; Michael W. Bruford; Ruiqiang Li; Ming Li

doi:10.1038/ng.3137

Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary history

Xuming Zhou, Boshi Wang, Qi Pan, Jinbo Zhang, Sudhir Kumar, Xiaoqing Sun, Zhijin Liu, Huijuan Pan, Yu Lin, Guangjian Liu, Wei Zhan, Mangzhou Li, Baoping Ren, Xingyong Ma, Hang Ruan, Chen Cheng, Dawei Wang, Fanglei Shi, Yuanyuan Hui, Yujing TaoChenglin Zhang, Pingfen Zhu, Zuofu Xiang, Wenkai Jiang, Jiang Chang, Hailong Wang, Zhisheng Cao, Zhi Jiang, Baoguo Li, Guang Yang, Christian Roos, Paul A. Garber, Michael W. Bruford, Ruiqiang Li, Ming Li

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Abstract

Colobines are a unique group of Old World monkeys that principally eat leaves and seeds rather than fruits and insects. We report the sequencing at 146× coverage, de novo assembly and analyses of the genome of a male golden snub-nosed monkey (Rhinopithecus roxellana) and resequencing at 30× coverage of three related species (Rhinopithecus bieti, Rhinopithecus brelichi and Rhinopithecus strykeri). Comparative analyses showed that Asian colobines have an enhanced ability to derive energy from fatty acids and to degrade xenobiotics. We found evidence for functional evolution in the colobine RNASE1 gene, encoding a key secretory RNase that digests the high concentrations of bacterial RNA derived from symbiotic microflora. Demographic reconstructions indicated that the profile of ancient effective population sizes for R. roxellana more closely resembles that of giant panda rather than its congeners. These findings offer new insights into the dietary adaptations and evolutionary history of colobine primates.

Original language	English (US)
Pages (from-to)	1303-1310
Number of pages	8
Journal	Nature Genetics
Volume	46
Issue number	12
DOIs	https://doi.org/10.1038/ng.3137
State	Published - Dec 11 2014
Externally published	Yes

ASJC Scopus subject areas

Genetics

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Zhou, X., Wang, B., Pan, Q., Zhang, J., Kumar, S., Sun, X., Liu, Z., Pan, H., Lin, Y., Liu, G., Zhan, W., Li, M., Ren, B., Ma, X., Ruan, H., Cheng, C., Wang, D., Shi, F., Hui, Y., ... Li, M. (2014). Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary history. Nature Genetics, 46(12), 1303-1310. https://doi.org/10.1038/ng.3137

Zhou, X, Wang, B, Pan, Q, Zhang, J, Kumar, S, Sun, X, Liu, Z, Pan, H, Lin, Y, Liu, G, Zhan, W, Li, M, Ren, B, Ma, X, Ruan, H, Cheng, C, Wang, D, Shi, F, Hui, Y, Tao, Y, Zhang, C, Zhu, P, Xiang, Z, Jiang, W, Chang, J, Wang, H, Cao, Z, Jiang, Z, Li, B, Yang, G, Roos, C, Garber, PA, Bruford, MW, Li, R & Li, M 2014, 'Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary history', Nature Genetics, vol. 46, no. 12, pp. 1303-1310. https://doi.org/10.1038/ng.3137

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abstract = "Colobines are a unique group of Old World monkeys that principally eat leaves and seeds rather than fruits and insects. We report the sequencing at 146× coverage, de novo assembly and analyses of the genome of a male golden snub-nosed monkey (Rhinopithecus roxellana) and resequencing at 30× coverage of three related species (Rhinopithecus bieti, Rhinopithecus brelichi and Rhinopithecus strykeri). Comparative analyses showed that Asian colobines have an enhanced ability to derive energy from fatty acids and to degrade xenobiotics. We found evidence for functional evolution in the colobine RNASE1 gene, encoding a key secretory RNase that digests the high concentrations of bacterial RNA derived from symbiotic microflora. Demographic reconstructions indicated that the profile of ancient effective population sizes for R. roxellana more closely resembles that of giant panda rather than its congeners. These findings offer new insights into the dietary adaptations and evolutionary history of colobine primates.",

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AU - Sun, Xiaoqing

AU - Liu, Zhijin

AU - Pan, Huijuan

AU - Lin, Yu

AU - Liu, Guangjian

AU - Zhan, Wei

AU - Li, Mangzhou

AU - Ren, Baoping

AU - Ma, Xingyong

AU - Ruan, Hang

AU - Cheng, Chen

AU - Wang, Dawei

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AU - Hui, Yuanyuan

AU - Tao, Yujing

AU - Zhang, Chenglin

AU - Zhu, Pingfen

AU - Xiang, Zuofu

AU - Jiang, Wenkai

AU - Chang, Jiang

AU - Wang, Hailong

AU - Cao, Zhisheng

AU - Jiang, Zhi

AU - Li, Baoguo

AU - Yang, Guang

AU - Roos, Christian

AU - Garber, Paul A.

AU - Bruford, Michael W.

AU - Li, Ruiqiang

AU - Li, Ming

PY - 2014/12/11

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Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary history

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