White matter density is increased in patients with hypothalamic hamartoma and multiple seizure types

T. E. Losey, S. C. Beeman, Y. T. Ng, J. F. Kerrigan, L. C. Baxter

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Many patients with hypothalamic hamartomas present in infancy with gelastic seizures of subcortical origin, but later develop additional seizure types, including complex partial, tonic, and generalized tonic-clonic seizures. The basic cellular mechanisms responsible for this evolution in seizure types are unknown. Using voxel-based morphometry of T1 weighted MRI scans we compared eight patients with only gelastic seizures with 16 age-matched patients with multiple seizure types and found significantly greater white matter density in the temporal lobes and cerebellum in those with multiple seizure types. This suggests that increased white matter density, perhaps resulting from maturational changes and resulting in increased brain connectivity, is associated with a higher likelihood of cortical involvement in epilepsy resulting from hypothalamic hamartoma.

Original languageEnglish (US)
Pages (from-to)212-215
Number of pages4
JournalEpilepsy Research
Volume93
Issue number2-3
DOIs
StatePublished - Feb 2011
Externally publishedYes

Keywords

  • Epileptogenesis
  • Gelastic seizure
  • Hypothalamic hamartoma
  • Voxel based morphometry

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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