TY - JOUR
T1 - When Two Strands Are Better Than One
T2 - The Mediators and Modulators of the Cellular Responses to Double-Stranded RNA
AU - Jacobs, Bertram
AU - Langland, Jeffrey
PY - 1996/5/15
Y1 - 1996/5/15
N2 - Double-stranded RNA is a potent inducer of Interferon, a modulator of the expression of a number of other genes involved in the response of cells to virus infection, an activator of the interferon-induced antiviral state, and may be involved in differentiation, induction of apoptosis, and control of oncogenic transformation. This review will attempt to summarize what is known about the cellular proteins that act to mediate the response of cells to double-stranded RNA and the viral and cellular macromolecules that may be able to modulate these responses.
AB - Double-stranded RNA is a potent inducer of Interferon, a modulator of the expression of a number of other genes involved in the response of cells to virus infection, an activator of the interferon-induced antiviral state, and may be involved in differentiation, induction of apoptosis, and control of oncogenic transformation. This review will attempt to summarize what is known about the cellular proteins that act to mediate the response of cells to double-stranded RNA and the viral and cellular macromolecules that may be able to modulate these responses.
UR - http://www.scopus.com/inward/record.url?scp=0030585155&partnerID=8YFLogxK
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U2 - 10.1006/viro.1996.0259
DO - 10.1006/viro.1996.0259
M3 - Article
C2 - 8638399
AN - SCOPUS:0030585155
VL - 219
SP - 339
EP - 349
JO - Virology
JF - Virology
SN - 0042-6822
IS - 2
ER -