TY - GEN
T1 - Waveform processing for protein multi-alignment by mapping location, structure and property function attributes
AU - O'Donnell, Brian
AU - Maurer, Alexander
AU - Papandreou-Suppappola, Antonia
PY - 2013/1/1
Y1 - 2013/1/1
N2 - We propose a pairwise protein structure alignment approach based on a joint similarity measure of multiple protein attributes. We map information on a protein's sequence location, structure and characteristic properties onto a highly-localized three-dimensional Gaussian waveform. By allowing the waveform to undergo unique transformations in the time-frequency plane, we allocate distinct parameters to represent the different attributes. Protein matching by expanding the mapped waveforms using appropriately designed basis waveform functions provides a similarity measure to encompass the multiple attributes. Simulations using data from a database demonstrate the performance of the joint alignment approach to infer relationships between proteins.
AB - We propose a pairwise protein structure alignment approach based on a joint similarity measure of multiple protein attributes. We map information on a protein's sequence location, structure and characteristic properties onto a highly-localized three-dimensional Gaussian waveform. By allowing the waveform to undergo unique transformations in the time-frequency plane, we allocate distinct parameters to represent the different attributes. Protein matching by expanding the mapped waveforms using appropriately designed basis waveform functions provides a similarity measure to encompass the multiple attributes. Simulations using data from a database demonstrate the performance of the joint alignment approach to infer relationships between proteins.
UR - http://www.scopus.com/inward/record.url?scp=84901248168&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901248168&partnerID=8YFLogxK
U2 - 10.1109/ACSSC.2013.6810270
DO - 10.1109/ACSSC.2013.6810270
M3 - Conference contribution
AN - SCOPUS:84901248168
SN - 9781479923908
T3 - Conference Record - Asilomar Conference on Signals, Systems and Computers
SP - 248
EP - 252
BT - Conference Record of the 47th Asilomar Conference on Signals, Systems and Computers
PB - IEEE Computer Society
T2 - 2013 47th Asilomar Conference on Signals, Systems and Computers
Y2 - 3 November 2013 through 6 November 2013
ER -