Waiting time on dialysis as the strongest modifiable risk factor for renal transplant outcomes: A paired donor kidney analysis

Herwig Ulf Meier-Kriesche, Bruce Kaplan

Research output: Contribution to journalArticle

485 Citations (Scopus)

Abstract

Background. Waiting time on dialysis has been shown to be associated with worse outcomes after living and cadaveric transplantation. To validate and quantify end-stage renal disease (ESRD) time as an independent risk factor for kidney transplantation, we compared the outcome of paired donor kidneys, destined to patients who had ESRD more than 2 years compared to patients who had ESRD less than 6 months. Methods. We analyzed data available from the U.S. Renal Data System database between 1988 and 1998 by Kaplan-Meier estimates and Cox proportional hazards models to quantify the effect of ESRD time on paired cadaveric kidneys and on all cadaveric kidneys compared to living-donated kidneys. Results. Five- and 10-year unadjusted graft survival rates were significantly worse in paired kidney recipients who had undergone more than 24 months of dialysis (58% and 29%, respectively) compared to paired kidney recipients who had undergone less than 6 months of dialysis (78% and 63%, respectively; P

Original languageEnglish (US)
Pages (from-to)1377-1381
Number of pages5
JournalTransplantation
Volume74
Issue number10
StatePublished - Nov 1 2002
Externally publishedYes

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Dialysis
Tissue Donors
Transplants
Kidney
Chronic Kidney Failure
Kaplan-Meier Estimate
Graft Survival
Proportional Hazards Models
Information Systems
Kidney Transplantation
Survival Rate
Transplantation
Databases

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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Waiting time on dialysis as the strongest modifiable risk factor for renal transplant outcomes : A paired donor kidney analysis. / Meier-Kriesche, Herwig Ulf; Kaplan, Bruce.

In: Transplantation, Vol. 74, No. 10, 01.11.2002, p. 1377-1381.

Research output: Contribution to journalArticle

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