In , we developed two different techniques to study volume mapping problem in Computer Graphics. The first one is to find a harmonic map from a 3 manifold to a 3D solid sphere and the second is a sphere carving algorithm which calculates the simplicial decomposition of volume adapted to surfaces. In this paper, we apply these two techniques to brain mapping problem. We use a tetrahedral mesh to represent the brain volume. The experimental results on both synthetic and brain volume data are reported. We suggest that 3D harmonic mapping of brain volumes to a solid sphere can provide a canonical coordinate system for feature identification and segmentation, as well as anatomical normalization.