Vitellogenin regulates hormonal dynamics in the worker caste of a eusocial insect

Karina R. Guidugli, Adriana M. Nascimento, Gro Amdam, Angel R. Barchuk, Stig Omholt, Zilá L P Simões, Klaus Hartfelder

Research output: Contribution to journalArticle

211 Citations (Scopus)

Abstract

Functionally sterile honey bee workers synthesize the yolk protein vitellogenin while performing nest tasks. The subsequent shift to foraging is linked to a reduced vitellogenin and an increased juvenile hormone (JH) titer. JH is a principal controller of vitellogenin expression and behavioral development. Yet, we show here that silencing of vitellogenin expression causes a significant increase in JH titer and its putative receptor. Mathematically, the increase corresponds to a dynamic dose-response. This role of vitellogenin in the tuning of the endocrine system is uncommon and may elucidate how an ancestral pathway of fertility regulation has been remodeled into a novel circuit controlling social behavior.

Original languageEnglish (US)
Pages (from-to)4961-4965
Number of pages5
JournalFEBS Letters
Volume579
Issue number22
DOIs
StatePublished - Sep 12 2005

Fingerprint

Vitellogenins
Social Class
Insects
Juvenile Hormones
Egg Proteins
Endocrine System
Honey
Social Behavior
Bees
Fertility
Tuning
Controllers
Networks (circuits)

Keywords

  • Age polyethism
  • Honey bee
  • Juvenile hormone
  • Ultraspiracle
  • Vitellogenin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Guidugli, K. R., Nascimento, A. M., Amdam, G., Barchuk, A. R., Omholt, S., Simões, Z. L. P., & Hartfelder, K. (2005). Vitellogenin regulates hormonal dynamics in the worker caste of a eusocial insect. FEBS Letters, 579(22), 4961-4965. https://doi.org/10.1016/j.febslet.2005.07.085

Vitellogenin regulates hormonal dynamics in the worker caste of a eusocial insect. / Guidugli, Karina R.; Nascimento, Adriana M.; Amdam, Gro; Barchuk, Angel R.; Omholt, Stig; Simões, Zilá L P; Hartfelder, Klaus.

In: FEBS Letters, Vol. 579, No. 22, 12.09.2005, p. 4961-4965.

Research output: Contribution to journalArticle

Guidugli, KR, Nascimento, AM, Amdam, G, Barchuk, AR, Omholt, S, Simões, ZLP & Hartfelder, K 2005, 'Vitellogenin regulates hormonal dynamics in the worker caste of a eusocial insect', FEBS Letters, vol. 579, no. 22, pp. 4961-4965. https://doi.org/10.1016/j.febslet.2005.07.085
Guidugli KR, Nascimento AM, Amdam G, Barchuk AR, Omholt S, Simões ZLP et al. Vitellogenin regulates hormonal dynamics in the worker caste of a eusocial insect. FEBS Letters. 2005 Sep 12;579(22):4961-4965. https://doi.org/10.1016/j.febslet.2005.07.085
Guidugli, Karina R. ; Nascimento, Adriana M. ; Amdam, Gro ; Barchuk, Angel R. ; Omholt, Stig ; Simões, Zilá L P ; Hartfelder, Klaus. / Vitellogenin regulates hormonal dynamics in the worker caste of a eusocial insect. In: FEBS Letters. 2005 ; Vol. 579, No. 22. pp. 4961-4965.
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