Vitellogenin regulates hormonal dynamics in the worker caste of a eusocial insect

Karina R. Guidugli; Adriana M. Nascimento; Gro Amdam; Angel R. Barchuk; Stig Omholt; Zilá L P Simões; Klaus Hartfelder

doi:10.1016/j.febslet.2005.07.085

Vitellogenin regulates hormonal dynamics in the worker caste of a eusocial insect

Karina R. Guidugli, Adriana M. Nascimento, Gro Amdam, Angel R. Barchuk, Stig Omholt, Zilá L P Simões, Klaus Hartfelder

Life Sciences, School of (SOLS)

Research output: Contribution to journal › Article › peer-review

265 Scopus citations

Abstract

Functionally sterile honey bee workers synthesize the yolk protein vitellogenin while performing nest tasks. The subsequent shift to foraging is linked to a reduced vitellogenin and an increased juvenile hormone (JH) titer. JH is a principal controller of vitellogenin expression and behavioral development. Yet, we show here that silencing of vitellogenin expression causes a significant increase in JH titer and its putative receptor. Mathematically, the increase corresponds to a dynamic dose-response. This role of vitellogenin in the tuning of the endocrine system is uncommon and may elucidate how an ancestral pathway of fertility regulation has been remodeled into a novel circuit controlling social behavior.

Original language	English (US)
Pages (from-to)	4961-4965
Number of pages	5
Journal	FEBS Letters
Volume	579
Issue number	22
DOIs	https://doi.org/10.1016/j.febslet.2005.07.085
State	Published - Sep 12 2005

Keywords

Age polyethism
Honey bee
Juvenile hormone
Ultraspiracle
Vitellogenin

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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title = "Vitellogenin regulates hormonal dynamics in the worker caste of a eusocial insect",

abstract = "Functionally sterile honey bee workers synthesize the yolk protein vitellogenin while performing nest tasks. The subsequent shift to foraging is linked to a reduced vitellogenin and an increased juvenile hormone (JH) titer. JH is a principal controller of vitellogenin expression and behavioral development. Yet, we show here that silencing of vitellogenin expression causes a significant increase in JH titer and its putative receptor. Mathematically, the increase corresponds to a dynamic dose-response. This role of vitellogenin in the tuning of the endocrine system is uncommon and may elucidate how an ancestral pathway of fertility regulation has been remodeled into a novel circuit controlling social behavior.",

keywords = "Age polyethism, Honey bee, Juvenile hormone, Ultraspiracle, Vitellogenin",

author = "Guidugli, {Karina R.} and Nascimento, {Adriana M.} and Gro Amdam and Barchuk, {Angel R.} and Stig Omholt and Sim{\~o}es, {Zil{\'a} L P} and Klaus Hartfelder",

note = "Funding Information: We thank Walter Goodman for a generous supply of juvenile hormone antibody, and Robert Page, Xavier Bell{\'e}s and Bert H{\"o}lldobler for critically reading and commenting on previous versions of this manuscript. Financial support by the Funda{\c c}{\~a}o de Amparo a Pesquisa do Estado de S{\~a}o Paulo (FAPESP, 1999/00719-6) and the Norwegian Research Council (Project no. 157851/432) is acknowledged.",

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AU - Guidugli, Karina R.

AU - Nascimento, Adriana M.

AU - Amdam, Gro

AU - Barchuk, Angel R.

AU - Omholt, Stig

AU - Simões, Zilá L P

AU - Hartfelder, Klaus

N1 - Funding Information: We thank Walter Goodman for a generous supply of juvenile hormone antibody, and Robert Page, Xavier Bellés and Bert Hölldobler for critically reading and commenting on previous versions of this manuscript. Financial support by the Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP, 1999/00719-6) and the Norwegian Research Council (Project no. 157851/432) is acknowledged.

PY - 2005/9/12

Y1 - 2005/9/12

N2 - Functionally sterile honey bee workers synthesize the yolk protein vitellogenin while performing nest tasks. The subsequent shift to foraging is linked to a reduced vitellogenin and an increased juvenile hormone (JH) titer. JH is a principal controller of vitellogenin expression and behavioral development. Yet, we show here that silencing of vitellogenin expression causes a significant increase in JH titer and its putative receptor. Mathematically, the increase corresponds to a dynamic dose-response. This role of vitellogenin in the tuning of the endocrine system is uncommon and may elucidate how an ancestral pathway of fertility regulation has been remodeled into a novel circuit controlling social behavior.

AB - Functionally sterile honey bee workers synthesize the yolk protein vitellogenin while performing nest tasks. The subsequent shift to foraging is linked to a reduced vitellogenin and an increased juvenile hormone (JH) titer. JH is a principal controller of vitellogenin expression and behavioral development. Yet, we show here that silencing of vitellogenin expression causes a significant increase in JH titer and its putative receptor. Mathematically, the increase corresponds to a dynamic dose-response. This role of vitellogenin in the tuning of the endocrine system is uncommon and may elucidate how an ancestral pathway of fertility regulation has been remodeled into a novel circuit controlling social behavior.

KW - Age polyethism

KW - Honey bee

KW - Juvenile hormone

KW - Ultraspiracle

KW - Vitellogenin

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Vitellogenin regulates hormonal dynamics in the worker caste of a eusocial insect

Abstract

Keywords

ASJC Scopus subject areas

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