Vitellogenin recognizes cell damage through membrane binding and shields living cells from reactive oxygen species

Heli Havukainen, Daniel Münch, Anne Baumann, Shi Zhong, Øyvind Halskau, Michelle Krogsgaard, Gro Amdam

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Background: Vitellogenin is a central regulator of honey bee life span by largely unknown mechanisms. Results: Honey bee vitellogenin has membrane affinity that is connected to cell damage recognition and antioxidant function. Conclusion: Membrane binding documents a new molecular behavior among vitellogenins. Significance: Vitellogenins are widespread phylogenetically, and their molecular behavior is essential for fitness traits in many animals.

Original languageEnglish (US)
Pages (from-to)28369-28381
Number of pages13
JournalJournal of Biological Chemistry
Volume288
Issue number39
DOIs
StatePublished - Sep 27 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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