TY - JOUR
T1 - Vitellogenin recognizes cell damage through membrane binding and shields living cells from reactive oxygen species
AU - Havukainen, Heli
AU - Münch, Daniel
AU - Baumann, Anne
AU - Zhong, Shi
AU - Halskau, Øyvind
AU - Krogsgaard, Michelle
AU - Amdam, Gro
PY - 2013/9/27
Y1 - 2013/9/27
N2 - Background: Vitellogenin is a central regulator of honey bee life span by largely unknown mechanisms. Results: Honey bee vitellogenin has membrane affinity that is connected to cell damage recognition and antioxidant function. Conclusion: Membrane binding documents a new molecular behavior among vitellogenins. Significance: Vitellogenins are widespread phylogenetically, and their molecular behavior is essential for fitness traits in many animals.
AB - Background: Vitellogenin is a central regulator of honey bee life span by largely unknown mechanisms. Results: Honey bee vitellogenin has membrane affinity that is connected to cell damage recognition and antioxidant function. Conclusion: Membrane binding documents a new molecular behavior among vitellogenins. Significance: Vitellogenins are widespread phylogenetically, and their molecular behavior is essential for fitness traits in many animals.
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U2 - 10.1074/jbc.M113.465021
DO - 10.1074/jbc.M113.465021
M3 - Article
C2 - 23897804
AN - SCOPUS:84884781144
SN - 0021-9258
VL - 288
SP - 28369
EP - 28381
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 39
ER -