Vitamins E and C are safe across a broad range of intakes

John N. Hathcock, Angela Azzi, Jeffrey Blumberg, Tammy Bray, Annette Dickinson, Balz Frei, Ishwarlal Jialal, Carol Johnston, Frank J. Kelly, Klaus Kraemer, Lester Packer, Sampath Parthasarathy, Helmut Sies, Maret G. Traber

Research output: Contribution to journalArticle

213 Citations (Scopus)

Abstract

A robust database shows that dietary supplements of vitamins E and C are safe for the general population. Because these nutrients supply antioxidant and other functions for homeostasis and protection against free radical damage, supplementation has been intensively studied. Because of perceived benefits, many persons consume quantities of vitamins E and C well above the recommended dietary allowances. As safety guidance, tolerable upper intake levels have been established by the Food and Nutrition Board, Institute of Medicine, at 1000 mg for vitamin E and 2000 mg for vitamin C in adults. Many clinical trials with these vitamins have involved subjects with various diseases, and no consistent pattern of adverse effects has occurred at any intake. Numerous studies of vitamin C supplementation have provided no pattern of evidence to support concerns about safety other than occasional gastrointestinal upset or mild diarrhea resulting from the osmotic effects of unabsorbed quantities of vitamin C. Evidence of bleeding effects and other potential adverse effects of high vitamin E intakes in humans is not convincing. Evidence of adverse effects of vitamin C that result from its effects on iron absorption and metabolism has not been confirmed in clinical trials. Thus, we conclude from clinical trial evidence that vitamin E supplements appear safe for most adults in amounts ≤1600 IU (1073 mg RRR-α-tocopherol or the molar equivalent of its esters) and that vitamin C supplements of ≤2000 mg/d are safe for most adults.

Original languageEnglish (US)
Pages (from-to)736-745
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume81
Issue number4
StatePublished - 2005

Fingerprint

Vitamin E
Ascorbic Acid
vitamin E
ascorbic acid
clinical trials
adverse effects
Clinical Trials
Tolerable Upper Intake Level
Safety
Recommended Dietary Allowances
Food
National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division
iron absorption
Tocopherols
Dietary Supplements
tocopherols
Vitamins
Free Radicals
hemorrhage
dietary supplements

Keywords

  • α-tocopherol
  • Ascorbic acid
  • Clinical trials
  • Risk assessment
  • Safety
  • Tocopherol
  • Vitamin C
  • Vitamin E

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Hathcock, J. N., Azzi, A., Blumberg, J., Bray, T., Dickinson, A., Frei, B., ... Traber, M. G. (2005). Vitamins E and C are safe across a broad range of intakes. American Journal of Clinical Nutrition, 81(4), 736-745.

Vitamins E and C are safe across a broad range of intakes. / Hathcock, John N.; Azzi, Angela; Blumberg, Jeffrey; Bray, Tammy; Dickinson, Annette; Frei, Balz; Jialal, Ishwarlal; Johnston, Carol; Kelly, Frank J.; Kraemer, Klaus; Packer, Lester; Parthasarathy, Sampath; Sies, Helmut; Traber, Maret G.

In: American Journal of Clinical Nutrition, Vol. 81, No. 4, 2005, p. 736-745.

Research output: Contribution to journalArticle

Hathcock, JN, Azzi, A, Blumberg, J, Bray, T, Dickinson, A, Frei, B, Jialal, I, Johnston, C, Kelly, FJ, Kraemer, K, Packer, L, Parthasarathy, S, Sies, H & Traber, MG 2005, 'Vitamins E and C are safe across a broad range of intakes', American Journal of Clinical Nutrition, vol. 81, no. 4, pp. 736-745.
Hathcock JN, Azzi A, Blumberg J, Bray T, Dickinson A, Frei B et al. Vitamins E and C are safe across a broad range of intakes. American Journal of Clinical Nutrition. 2005;81(4):736-745.
Hathcock, John N. ; Azzi, Angela ; Blumberg, Jeffrey ; Bray, Tammy ; Dickinson, Annette ; Frei, Balz ; Jialal, Ishwarlal ; Johnston, Carol ; Kelly, Frank J. ; Kraemer, Klaus ; Packer, Lester ; Parthasarathy, Sampath ; Sies, Helmut ; Traber, Maret G. / Vitamins E and C are safe across a broad range of intakes. In: American Journal of Clinical Nutrition. 2005 ; Vol. 81, No. 4. pp. 736-745.
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