10 Citations (Scopus)

Abstract

Low plasma amyloid-β (Aβ) is linked to Alzheimer's disease. Since vitamin D cleared brain Aβ in vitro, this 8-week trial examined whether vitamin D increased plasma Aβ40. Vitamin D insufficient adults (6/18 M/F; 64.3 ± 10.9 y) were randomized to placebo or vitamin (50,000 IU/week) treatments. The vitamin group experienced greater plasma Aβ40 change than controls, 14.9 ± 12.0 and 12.8 ± 12.8 pg/mL (p=0.045; effect size, 0.228). Change in Aβ40 for older participants (≥60 y) was 18.3 ± 33.6 and 3.2 ± 44.5 pg/mL for vitamin (n=4) and placebo (n=4) groups (effect size, 0.295). Thus, vitamin D may increase plasma Aβ, particularly in older adults, suggesting decreased brain Aβ.

Original languageEnglish (US)
Pages (from-to)843-847
Number of pages5
JournalJournal of Alzheimer's Disease
Volume52
Issue number3
DOIs
StatePublished - 2016

Fingerprint

Vitamin D
Randomized Controlled Trials
Vitamins
Placebos
Brain
Amyloid
Alzheimer Disease
Therapeutics

Keywords

  • Alzheimer's disease
  • amyloid-β
  • P-glycoprotein
  • plasma Aβ
  • Vitamin D

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

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title = "Vitamin D Supplementation Appears to Increase Plasma Aβ40 in Vitamin D Insufficient Older Adults: A Pilot Randomized Controlled Trial",
abstract = "Low plasma amyloid-β (Aβ) is linked to Alzheimer's disease. Since vitamin D cleared brain Aβ in vitro, this 8-week trial examined whether vitamin D increased plasma Aβ40. Vitamin D insufficient adults (6/18 M/F; 64.3 ± 10.9 y) were randomized to placebo or vitamin (50,000 IU/week) treatments. The vitamin group experienced greater plasma Aβ40 change than controls, 14.9 ± 12.0 and 12.8 ± 12.8 pg/mL (p=0.045; effect size, 0.228). Change in Aβ40 for older participants (≥60 y) was 18.3 ± 33.6 and 3.2 ± 44.5 pg/mL for vitamin (n=4) and placebo (n=4) groups (effect size, 0.295). Thus, vitamin D may increase plasma Aβ, particularly in older adults, suggesting decreased brain Aβ.",
keywords = "Alzheimer's disease, amyloid-β, P-glycoprotein, plasma Aβ, Vitamin D",
author = "Miller, {Brendan J.} and Corrie Whisner and Carol Johnston",
year = "2016",
doi = "10.3233/JAD-150901",
language = "English (US)",
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pages = "843--847",
journal = "Journal of Alzheimer's Disease",
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TY - JOUR

T1 - Vitamin D Supplementation Appears to Increase Plasma Aβ40 in Vitamin D Insufficient Older Adults

T2 - A Pilot Randomized Controlled Trial

AU - Miller, Brendan J.

AU - Whisner, Corrie

AU - Johnston, Carol

PY - 2016

Y1 - 2016

N2 - Low plasma amyloid-β (Aβ) is linked to Alzheimer's disease. Since vitamin D cleared brain Aβ in vitro, this 8-week trial examined whether vitamin D increased plasma Aβ40. Vitamin D insufficient adults (6/18 M/F; 64.3 ± 10.9 y) were randomized to placebo or vitamin (50,000 IU/week) treatments. The vitamin group experienced greater plasma Aβ40 change than controls, 14.9 ± 12.0 and 12.8 ± 12.8 pg/mL (p=0.045; effect size, 0.228). Change in Aβ40 for older participants (≥60 y) was 18.3 ± 33.6 and 3.2 ± 44.5 pg/mL for vitamin (n=4) and placebo (n=4) groups (effect size, 0.295). Thus, vitamin D may increase plasma Aβ, particularly in older adults, suggesting decreased brain Aβ.

AB - Low plasma amyloid-β (Aβ) is linked to Alzheimer's disease. Since vitamin D cleared brain Aβ in vitro, this 8-week trial examined whether vitamin D increased plasma Aβ40. Vitamin D insufficient adults (6/18 M/F; 64.3 ± 10.9 y) were randomized to placebo or vitamin (50,000 IU/week) treatments. The vitamin group experienced greater plasma Aβ40 change than controls, 14.9 ± 12.0 and 12.8 ± 12.8 pg/mL (p=0.045; effect size, 0.228). Change in Aβ40 for older participants (≥60 y) was 18.3 ± 33.6 and 3.2 ± 44.5 pg/mL for vitamin (n=4) and placebo (n=4) groups (effect size, 0.295). Thus, vitamin D may increase plasma Aβ, particularly in older adults, suggesting decreased brain Aβ.

KW - Alzheimer's disease

KW - amyloid-β

KW - P-glycoprotein

KW - plasma Aβ

KW - Vitamin D

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