Vitamin D Supplementation Appears to Increase Plasma Aβ40 in Vitamin D Insufficient Older Adults: A Pilot Randomized Controlled Trial

Brendan J. Miller, Corrie Whisner, Carol Johnston

Research output: Contribution to journalArticle

12 Scopus citations


Low plasma amyloid-β (Aβ) is linked to Alzheimer's disease. Since vitamin D cleared brain Aβ in vitro, this 8-week trial examined whether vitamin D increased plasma Aβ40. Vitamin D insufficient adults (6/18 M/F; 64.3 ± 10.9 y) were randomized to placebo or vitamin (50,000 IU/week) treatments. The vitamin group experienced greater plasma Aβ40 change than controls, 14.9 ± 12.0 and 12.8 ± 12.8 pg/mL (p=0.045; effect size, 0.228). Change in Aβ40 for older participants (≥60 y) was 18.3 ± 33.6 and 3.2 ± 44.5 pg/mL for vitamin (n=4) and placebo (n=4) groups (effect size, 0.295). Thus, vitamin D may increase plasma Aβ, particularly in older adults, suggesting decreased brain Aβ.

Original languageEnglish (US)
Pages (from-to)843-847
Number of pages5
JournalJournal of Alzheimer's Disease
Issue number3
StatePublished - 2016



  • Alzheimer's disease
  • amyloid-β
  • P-glycoprotein
  • plasma Aβ
  • Vitamin D

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this