Vitamin D Nutrient-Gene Interactions and Healthful Aging

Mark R. Haussler, Rimpi K. Saini, Marya S. Sabir, Christopher M. Dussik, Zainab Khan, G. Kerr Whitfield, Kristin P. Griffin, Ichiro Kaneko, Peter Jurutka

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

1,25-Dihydroxyvitamin D3 (1,25D) is the endocrine metabolite of vitamin D that signals through binding to the vitamin D receptor (VDR). The ligand-receptor complex transcriptionally regulates genes that encode factors promoting intestinal calcium and phosphate absorption plus bone remodeling, maintaining a skeleton with reduced risk of age-related osteoporotic fractures. 1,25D/VDR signaling further exerts feedback control of mineral ions via regulation of FGF23, klotho, and CYP24A1 to prevent age-related, ectopic calcification, and associated pathologies. Vitamin D also elicits xenobiotic detoxification, oxidative stress reduction, antimicrobial defense, immunoregulation, anti-inflammatory/anticancer actions, and cardiovascular benefits. 1,25D exerts neuroprotective actions against excitotoxicity, and induces serotonin mood elevator to support cognitive function and prosocial behavior. Nutrient, low-affinity VDR ligands including curcumin, polyunsaturated fatty acids, and delphinidin/anthocyanidins initiate VDR signaling, whereas longevity agents such as resveratrol and SIRT1 potentiate VDR signaling. Therefore, liganded VDR modulates the expression of a network of genes that facilitates health span by delaying the chronic diseases of aging.

Original languageEnglish (US)
Title of host publicationMolecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series
PublisherElsevier Inc.
Pages449-471
Number of pages23
ISBN (Electronic)9780128018279
ISBN (Print)9780128018163
DOIs
StatePublished - Apr 28 2016

Keywords

  • 1,25-Dihydroxyvitamin D
  • Anti-inflammatory
  • Anticancer nutrient
  • Ectopic calcification
  • FGF23
  • Klotho
  • Neuroprotection
  • Osteoporosis
  • Vitamin D receptor

ASJC Scopus subject areas

  • Medicine(all)

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    Haussler, M. R., Saini, R. K., Sabir, M. S., Dussik, C. M., Khan, Z., Whitfield, G. K., Griffin, K. P., Kaneko, I., & Jurutka, P. (2016). Vitamin D Nutrient-Gene Interactions and Healthful Aging. In Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series (pp. 449-471). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-801816-3.00033-9