Abstract
The hormonal precursor and parent compound, vitamin D3, either can be obtained in the diet or formed from 7-dehydrocholesterol in skin (epidermis) via a nonenzymatic, UV light-dependent reaction (Figure 1.1). Vitamin D3 is then transported to the liver, where it is hydroxylated at the C-25 position of the side chain to produce 25-hydroxyvitamin D3 (25D), which is the major circulating form of vitamin D3. The nal step in the production of the hormonal form occurs mainly, but not exclusively, in the kidney via a tightly regulated 1α-hydroxylation reaction (Figure 1.1). The cytochrome P450-containing (CYP) enzymes that catalyze 25-and 1a-hydroxylations are microsomal CYP2R1 (Cheng et al. 2003) and mitochondrial CYP27B1, respectively. As depicted in Figure 1.1, 1,25-dihydroxyvitamin D3 (1,25D) circulates, bound to plasma vitamin D binding protein, to various target tissues to exert its endocrine actions, which are mediated by the vitamin D receptor (VDR). Many of the long-recognized functions of 1,25D involve the regulation of calcium and phosphate metabolism, raising the blood levels of these ions to facilitate bone mineralization, as well as activating bone resorption as part of the remodeling cycle (Haussler et al. 2010).
| Original language | English (US) |
|---|---|
| Title of host publication | Vitamin D |
| Subtitle of host publication | Oxidative Stress, Immunity, and Aging |
| Publisher | CRC Press |
| Pages | 3-36 |
| Number of pages | 34 |
| ISBN (Electronic) | 9781439850213 |
| ISBN (Print) | 9781439850206 |
| DOIs | |
| State | Published - Jan 1 2012 |
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ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Vitamin D : A fountain of youth in gene regulation. / Jurutka, Peter; Whitfield, G. Kerr; Forster, Ryan; Batie, Shane; Lee, Jamie; Haussler, Mark R.
Vitamin D: Oxidative Stress, Immunity, and Aging. CRC Press, 2012. p. 3-36.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Vitamin D
T2 - A fountain of youth in gene regulation
AU - Jurutka, Peter
AU - Whitfield, G. Kerr
AU - Forster, Ryan
AU - Batie, Shane
AU - Lee, Jamie
AU - Haussler, Mark R.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - The hormonal precursor and parent compound, vitamin D3, either can be obtained in the diet or formed from 7-dehydrocholesterol in skin (epidermis) via a nonenzymatic, UV light-dependent reaction (Figure 1.1). Vitamin D3 is then transported to the liver, where it is hydroxylated at the C-25 position of the side chain to produce 25-hydroxyvitamin D3 (25D), which is the major circulating form of vitamin D3. The nal step in the production of the hormonal form occurs mainly, but not exclusively, in the kidney via a tightly regulated 1α-hydroxylation reaction (Figure 1.1). The cytochrome P450-containing (CYP) enzymes that catalyze 25-and 1a-hydroxylations are microsomal CYP2R1 (Cheng et al. 2003) and mitochondrial CYP27B1, respectively. As depicted in Figure 1.1, 1,25-dihydroxyvitamin D3 (1,25D) circulates, bound to plasma vitamin D binding protein, to various target tissues to exert its endocrine actions, which are mediated by the vitamin D receptor (VDR). Many of the long-recognized functions of 1,25D involve the regulation of calcium and phosphate metabolism, raising the blood levels of these ions to facilitate bone mineralization, as well as activating bone resorption as part of the remodeling cycle (Haussler et al. 2010).
AB - The hormonal precursor and parent compound, vitamin D3, either can be obtained in the diet or formed from 7-dehydrocholesterol in skin (epidermis) via a nonenzymatic, UV light-dependent reaction (Figure 1.1). Vitamin D3 is then transported to the liver, where it is hydroxylated at the C-25 position of the side chain to produce 25-hydroxyvitamin D3 (25D), which is the major circulating form of vitamin D3. The nal step in the production of the hormonal form occurs mainly, but not exclusively, in the kidney via a tightly regulated 1α-hydroxylation reaction (Figure 1.1). The cytochrome P450-containing (CYP) enzymes that catalyze 25-and 1a-hydroxylations are microsomal CYP2R1 (Cheng et al. 2003) and mitochondrial CYP27B1, respectively. As depicted in Figure 1.1, 1,25-dihydroxyvitamin D3 (1,25D) circulates, bound to plasma vitamin D binding protein, to various target tissues to exert its endocrine actions, which are mediated by the vitamin D receptor (VDR). Many of the long-recognized functions of 1,25D involve the regulation of calcium and phosphate metabolism, raising the blood levels of these ions to facilitate bone mineralization, as well as activating bone resorption as part of the remodeling cycle (Haussler et al. 2010).
UR - http://www.scopus.com/inward/record.url?scp=84926648448&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84926648448&partnerID=8YFLogxK
U2 - 10.1201/b13714
DO - 10.1201/b13714
M3 - Chapter
AN - SCOPUS:84926648448
SN - 9781439850206
SP - 3
EP - 36
BT - Vitamin D
PB - CRC Press
ER -