Viruses for tumor therapy

John Bell, Grant McFadden

Research output: Contribution to journalReview articlepeer-review

105 Scopus citations


Oncolytic virotherapy exploits live viruses with selective tropism for cancerous cells and tissues to treat cancer. As discussed here, the field has progressed considerably as a result of both the successes and failures of previous and on-going clinical trials for various cancers. These studies indicate that oncolytic viruses are remarkably safe and more efficacious when virus replication stimulates sustained antitumor immune responses. In the future, virotherapy should be combined with immunomodulatory reagents that target immune tolerance to established cancers.

Original languageEnglish (US)
Pages (from-to)260-265
Number of pages6
JournalCell Host and Microbe
Issue number3
StatePublished - Mar 12 2014
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology


Dive into the research topics of 'Viruses for tumor therapy'. Together they form a unique fingerprint.

Cite this