Viruses for tumor therapy

John Bell, Grant McFadden

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations

Abstract

Oncolytic virotherapy exploits live viruses with selective tropism for cancerous cells and tissues to treat cancer. As discussed here, the field has progressed considerably as a result of both the successes and failures of previous and on-going clinical trials for various cancers. These studies indicate that oncolytic viruses are remarkably safe and more efficacious when virus replication stimulates sustained antitumor immune responses. In the future, virotherapy should be combined with immunomodulatory reagents that target immune tolerance to established cancers.

Original languageEnglish (US)
Pages (from-to)260-265
Number of pages6
JournalCell Host and Microbe
Volume15
Issue number3
DOIs
StatePublished - Mar 12 2014

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

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