Viruses for tumor therapy

John Bell; Grant McFadden

doi:10.1016/j.chom.2014.01.002

Viruses for tumor therapy

John Bell, Grant McFadden

Research output: Contribution to journal › Review article › peer-review

105 Scopus citations

Abstract

Oncolytic virotherapy exploits live viruses with selective tropism for cancerous cells and tissues to treat cancer. As discussed here, the field has progressed considerably as a result of both the successes and failures of previous and on-going clinical trials for various cancers. These studies indicate that oncolytic viruses are remarkably safe and more efficacious when virus replication stimulates sustained antitumor immune responses. In the future, virotherapy should be combined with immunomodulatory reagents that target immune tolerance to established cancers.

Original language	English (US)
Pages (from-to)	260-265
Number of pages	6
Journal	Cell Host and Microbe
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/j.chom.2014.01.002
State	Published - Mar 12 2014
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

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10.1016/j.chom.2014.01.002

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title = "Viruses for tumor therapy",

abstract = "Oncolytic virotherapy exploits live viruses with selective tropism for cancerous cells and tissues to treat cancer. As discussed here, the field has progressed considerably as a result of both the successes and failures of previous and on-going clinical trials for various cancers. These studies indicate that oncolytic viruses are remarkably safe and more efficacious when virus replication stimulates sustained antitumor immune responses. In the future, virotherapy should be combined with immunomodulatory reagents that target immune tolerance to established cancers.",

author = "John Bell and Grant McFadden",

note = "Funding Information: J.B.{\textquoteright}s lab is supported by the Ontario Institute for Cancer Research, the Canadian Institute for Health Research, and the Terry Fox Foundation, and G.M.{\textquoteright}s lab is supported by NIH grants R01 AI080607, R01 CA138541, and R01 AI100987. ",

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AU - McFadden, Grant

N1 - Funding Information: J.B.’s lab is supported by the Ontario Institute for Cancer Research, the Canadian Institute for Health Research, and the Terry Fox Foundation, and G.M.’s lab is supported by NIH grants R01 AI080607, R01 CA138541, and R01 AI100987.

PY - 2014/3/12

Y1 - 2014/3/12

N2 - Oncolytic virotherapy exploits live viruses with selective tropism for cancerous cells and tissues to treat cancer. As discussed here, the field has progressed considerably as a result of both the successes and failures of previous and on-going clinical trials for various cancers. These studies indicate that oncolytic viruses are remarkably safe and more efficacious when virus replication stimulates sustained antitumor immune responses. In the future, virotherapy should be combined with immunomodulatory reagents that target immune tolerance to established cancers.

AB - Oncolytic virotherapy exploits live viruses with selective tropism for cancerous cells and tissues to treat cancer. As discussed here, the field has progressed considerably as a result of both the successes and failures of previous and on-going clinical trials for various cancers. These studies indicate that oncolytic viruses are remarkably safe and more efficacious when virus replication stimulates sustained antitumor immune responses. In the future, virotherapy should be combined with immunomodulatory reagents that target immune tolerance to established cancers.

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Viruses for tumor therapy

Abstract

ASJC Scopus subject areas

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