Virus-induced cell fusion enhanced by phytohaemagglutinin

P. Reeve, G. Hewlett, H. Watkins, D. J. Alexander, G. Poste

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

ONCOGENIC transformation by viruses or chemicals1-5, treatment with proteolytic enzymes1,6 and infection with nononcogenic enveloped viruses7,8, produce cell surface alterations that increase cellular susceptibility to agglutination by plant lectins. More recently, lectins have been used to modify the replication and cytopathogenicity of enveloped viruses grown in normal cells9,10. It has been shown that treatment of cells with con A inhibits paramyxovirus-induced cell fusion.11 In contrast, the results reported here indicate that another plant lectin, phytohaemagglutinin (PHA), can enhance the fusion of cells infected with the paramyxovirus Newcastle disease virus (NDV).

Original languageEnglish (US)
Pages (from-to)355-356
Number of pages2
JournalNature
Volume249
Issue number5455
DOIs
StatePublished - 1974
Externally publishedYes

ASJC Scopus subject areas

  • General

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