Virulence and competitive ability in genetically diverse malaria infections

Jacobus C. De Roode, Riccardo Pansini, Sandra J. Cheesman, Michelle E H Helinski, Silvie Huijben, Andrew R. Wargo, Andrew S. Bell, Brian H K Chan, David Walliker, Andrew F. Read

Research output: Contribution to journalArticle

245 Citations (Scopus)

Abstract

Explaining parasite virulence is a great challenge for evolutionary biology. Intuitively, parasites that depend on their hosts for their survival should be benign to their hosts, yet many parasites cause harm. One explanation for this is that within-host competition favors virulence, with more virulent strains having a competitive advantage in genetically diverse infections. This idea, which is well supported in theory, remains untested empirically. Here we provide evidence that within-host competition does indeed select for high parasite virulence. We examine the rodent malaria Plasmodium chabaudi in laboratory mice, a parasite-host system in which virulence can be easily monitored and competing strains quantified by using strain-specific real-time PCR. As predicted, we found a strong relationship between parasite virulence and competitive ability, so that more virulent strains have a competitive advantage in mixed-strain infections. In transmission experiments, we found that the strain composition of the parasite populations in mosquitoes was directly correlated with the composition of the blood-stage parasite population. Thus, the outcome of within-host competition determined relative transmission success. Our results imply that within-host competition is a major factor driving the evolution of virulence and can explain why many parasites harm their hosts.

Original languageEnglish (US)
Pages (from-to)7624-7628
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume102
Issue number21
DOIs
StatePublished - May 24 2005
Externally publishedYes

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Malaria
Virulence
Parasites
Infection
Plasmodium chabaudi
Culicidae
Coinfection
Population
Real-Time Polymerase Chain Reaction
Rodentia

Keywords

  • Competition
  • Evolution
  • Mixed infection
  • Parasite
  • Plasmodium

ASJC Scopus subject areas

  • General

Cite this

Virulence and competitive ability in genetically diverse malaria infections. / De Roode, Jacobus C.; Pansini, Riccardo; Cheesman, Sandra J.; Helinski, Michelle E H; Huijben, Silvie; Wargo, Andrew R.; Bell, Andrew S.; Chan, Brian H K; Walliker, David; Read, Andrew F.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 21, 24.05.2005, p. 7624-7628.

Research output: Contribution to journalArticle

De Roode, JC, Pansini, R, Cheesman, SJ, Helinski, MEH, Huijben, S, Wargo, AR, Bell, AS, Chan, BHK, Walliker, D & Read, AF 2005, 'Virulence and competitive ability in genetically diverse malaria infections', Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 21, pp. 7624-7628. https://doi.org/10.1073/pnas.0500078102
De Roode, Jacobus C. ; Pansini, Riccardo ; Cheesman, Sandra J. ; Helinski, Michelle E H ; Huijben, Silvie ; Wargo, Andrew R. ; Bell, Andrew S. ; Chan, Brian H K ; Walliker, David ; Read, Andrew F. / Virulence and competitive ability in genetically diverse malaria infections. In: Proceedings of the National Academy of Sciences of the United States of America. 2005 ; Vol. 102, No. 21. pp. 7624-7628.
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