Viral TNF inhibitors as potential therapeutics

Masmudur Rahman, Alexandra R. Lucas, Douglas McFadden

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)

Abstract

The immune system functions by maintaining a delicate balance between the activities of pro-inflammatory and anti-inflammatory pathways. Unbalanced activation of these pathways of ten leads to the development of serious inflammatory diseases. TNF (Tumor Necrosis Factor) is a key pro-inflammatory cytokine, which can cause several inflammatory diseases when inappropriately up-regulated. Inhibition of TNF activities by using modulatory recombinant proteins has become a successful therapeutic approach to control TNF activity levels but these anti-TNF reagents also have risks and certain limitations. Biological molecules with a different mode of action in regulating TNF biology might provide a clinically useful alternative to the current therapeutics or in some cases might be efficacious in combination with existing anti-TNF therapies. TNF is also a powerful host defense cytokine commonly induced in the host response against various invading pathogens. Many viral pathogens can block TNF function by encoding modulators of TNF, its receptors or downstream signaling pathways. Here, we review the known virus-encoded TNF inhibitors and evaluate their potential as alternative future anti-TNF therapies.

Original languageEnglish (US)
Title of host publicationPathogen-Derived Immunomodulatory Molecules
EditorsPadraic Fallon
Pages64-77
Number of pages14
DOIs
StatePublished - Dec 1 2009
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume666
ISSN (Print)0065-2598

Fingerprint

Tumor Necrosis Factor-alpha
Therapeutics
Pathogens
Cytokines
Tumor Necrosis Factor Receptors
Immune system
Viruses
Recombinant Proteins
Modulators
Immune System
Anti-Inflammatory Agents
Chemical activation
Molecules

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Rahman, M., Lucas, A. R., & McFadden, D. (2009). Viral TNF inhibitors as potential therapeutics. In P. Fallon (Ed.), Pathogen-Derived Immunomodulatory Molecules (pp. 64-77). (Advances in Experimental Medicine and Biology; Vol. 666). https://doi.org/10.1007/978-1-4419-1601-3_5

Viral TNF inhibitors as potential therapeutics. / Rahman, Masmudur; Lucas, Alexandra R.; McFadden, Douglas.

Pathogen-Derived Immunomodulatory Molecules. ed. / Padraic Fallon. 2009. p. 64-77 (Advances in Experimental Medicine and Biology; Vol. 666).

Research output: Chapter in Book/Report/Conference proceedingChapter

Rahman, M, Lucas, AR & McFadden, D 2009, Viral TNF inhibitors as potential therapeutics. in P Fallon (ed.), Pathogen-Derived Immunomodulatory Molecules. Advances in Experimental Medicine and Biology, vol. 666, pp. 64-77. https://doi.org/10.1007/978-1-4419-1601-3_5
Rahman M, Lucas AR, McFadden D. Viral TNF inhibitors as potential therapeutics. In Fallon P, editor, Pathogen-Derived Immunomodulatory Molecules. 2009. p. 64-77. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4419-1601-3_5
Rahman, Masmudur ; Lucas, Alexandra R. ; McFadden, Douglas. / Viral TNF inhibitors as potential therapeutics. Pathogen-Derived Immunomodulatory Molecules. editor / Padraic Fallon. 2009. pp. 64-77 (Advances in Experimental Medicine and Biology).
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