Viral, host and environmental risk factors for hepatocellular carcinoma

A prospective study in Haimen City, China

W. T. London, A. A. Evans, K. McGlynn, Kenneth Buetow, P. An, L. Gao, E. Lustbader, E. Ross, G. Chen, F. Shen

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

To identify specific environmental, viral, and genetic risk factors for hepatocellular carcinoma (HCC) and the interaction of such factors, we are conducting a prospective study in a high-incidence area of China. Questionnaires were completed and biosamples collected by 60,984 men ages 30-64 years, at study entry. Within 2.5 years, 183 deaths from HCC had occurred. Each HCC case was matched with 5 controls and compared for items on the questionnaire. In addition to chronic hepatitis B virus (HBV) infection, the significant risk factors were: occupation (peasant), corn consumption (in the 1970s), family history of HCC, and history of an episode of acute hepatitis as an adult. HBV, consumption of aflatoxins, a genetic factor, and possibly a second hepatitis virus infection contribute to the risk of HCC.

Original languageEnglish (US)
Pages (from-to)155-161
Number of pages7
JournalIntervirology
Volume38
Issue number3-4
StatePublished - 1995
Externally publishedYes

Fingerprint

Hepatocellular Carcinoma
China
Prospective Studies
Virus Diseases
Hepatitis B virus
Hepatitis Viruses
Aflatoxins
Chronic Hepatitis B
Occupations
Hepatitis
Zea mays
Incidence
Surveys and Questionnaires

Keywords

  • Aflatoxin
  • Genetic susceptibility
  • Hepatitis B virus
  • Hepatocellular carcinoma

ASJC Scopus subject areas

  • Virology

Cite this

London, W. T., Evans, A. A., McGlynn, K., Buetow, K., An, P., Gao, L., ... Shen, F. (1995). Viral, host and environmental risk factors for hepatocellular carcinoma: A prospective study in Haimen City, China. Intervirology, 38(3-4), 155-161.

Viral, host and environmental risk factors for hepatocellular carcinoma : A prospective study in Haimen City, China. / London, W. T.; Evans, A. A.; McGlynn, K.; Buetow, Kenneth; An, P.; Gao, L.; Lustbader, E.; Ross, E.; Chen, G.; Shen, F.

In: Intervirology, Vol. 38, No. 3-4, 1995, p. 155-161.

Research output: Contribution to journalArticle

London, WT, Evans, AA, McGlynn, K, Buetow, K, An, P, Gao, L, Lustbader, E, Ross, E, Chen, G & Shen, F 1995, 'Viral, host and environmental risk factors for hepatocellular carcinoma: A prospective study in Haimen City, China', Intervirology, vol. 38, no. 3-4, pp. 155-161.
London, W. T. ; Evans, A. A. ; McGlynn, K. ; Buetow, Kenneth ; An, P. ; Gao, L. ; Lustbader, E. ; Ross, E. ; Chen, G. ; Shen, F. / Viral, host and environmental risk factors for hepatocellular carcinoma : A prospective study in Haimen City, China. In: Intervirology. 1995 ; Vol. 38, No. 3-4. pp. 155-161.
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