Viral, host and environmental risk factors for hepatocellular carcinoma: A prospective study in Haimen city, China

W. Thomas London; Alison A. Evans; Katherine Mcglynn; Kenneth Buetow; Pin G. An; Long Long Gao; Edward Lustbader; Eric Ross; Gong Chao Chen; Fu Min Shen

doi:10.1159/000150426

Viral, host and environmental risk factors for hepatocellular carcinoma: A prospective study in Haimen city, China

W. Thomas London, Alison A. Evans, Katherine Mcglynn, Kenneth Buetow, Pin G. An, Long Long Gao, Edward Lustbader, Eric Ross, Gong Chao Chen, Fu Min Shen

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

To identify specific environmental, viral, and genetic risk factors for hepatocellular carcinoma (HCC) and the interaction of such factors, we are conducting a prospective study in a high-incidence area of China. Questionnaires were completed and biosamples collected by 60,984 men ages 30-64 years, at study entry. Within 2.5 years, 183 deaths from HCC had occurred. Each HCC case was matched with 5 controls and compared for items on the questionnaire. In addition to chronic hepatitis B virus (HBV) infection, the significant risk factors were: Occupation (peasant), corn consumption (in the 1970s), family history of HCC, and history of an episode of acute hepatitis as an adult. HBV, consumption of aflatoxins, a genetic factor, and possibly a second hepatitis virus infection contribute to the risk of HCC.

Original language	English (US)
Pages (from-to)	155-161
Number of pages	7
Journal	Intervirology
Volume	38
Issue number	3-4
DOIs	https://doi.org/10.1159/000150426
State	Published - 1995
Externally published	Yes

Keywords

Aflatoxin
Genetic susceptibility
Hepatitis B virus
Hepatocellular carcinoma

ASJC Scopus subject areas

Virology
Infectious Diseases

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10.1159/000150426

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title = "Viral, host and environmental risk factors for hepatocellular carcinoma: A prospective study in Haimen city, China",

abstract = "To identify specific environmental, viral, and genetic risk factors for hepatocellular carcinoma (HCC) and the interaction of such factors, we are conducting a prospective study in a high-incidence area of China. Questionnaires were completed and biosamples collected by 60,984 men ages 30-64 years, at study entry. Within 2.5 years, 183 deaths from HCC had occurred. Each HCC case was matched with 5 controls and compared for items on the questionnaire. In addition to chronic hepatitis B virus (HBV) infection, the significant risk factors were: Occupation (peasant), corn consumption (in the 1970s), family history of HCC, and history of an episode of acute hepatitis as an adult. HBV, consumption of aflatoxins, a genetic factor, and possibly a second hepatitis virus infection contribute to the risk of HCC.",

keywords = "Aflatoxin, Genetic susceptibility, Hepatitis B virus, Hepatocellular carcinoma",

author = "London, {W. Thomas} and Evans, {Alison A.} and Katherine Mcglynn and Kenneth Buetow and An, {Pin G.} and Gao, {Long Long} and Edward Lustbader and Eric Ross and Chen, {Gong Chao} and Shen, {Fu Min}",

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doi = "10.1159/000150426",

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T2 - A prospective study in Haimen city, China

AU - London, W. Thomas

AU - Evans, Alison A.

AU - Mcglynn, Katherine

AU - Buetow, Kenneth

AU - An, Pin G.

AU - Gao, Long Long

AU - Lustbader, Edward

AU - Ross, Eric

AU - Chen, Gong Chao

AU - Shen, Fu Min

PY - 1995

Y1 - 1995

N2 - To identify specific environmental, viral, and genetic risk factors for hepatocellular carcinoma (HCC) and the interaction of such factors, we are conducting a prospective study in a high-incidence area of China. Questionnaires were completed and biosamples collected by 60,984 men ages 30-64 years, at study entry. Within 2.5 years, 183 deaths from HCC had occurred. Each HCC case was matched with 5 controls and compared for items on the questionnaire. In addition to chronic hepatitis B virus (HBV) infection, the significant risk factors were: Occupation (peasant), corn consumption (in the 1970s), family history of HCC, and history of an episode of acute hepatitis as an adult. HBV, consumption of aflatoxins, a genetic factor, and possibly a second hepatitis virus infection contribute to the risk of HCC.

AB - To identify specific environmental, viral, and genetic risk factors for hepatocellular carcinoma (HCC) and the interaction of such factors, we are conducting a prospective study in a high-incidence area of China. Questionnaires were completed and biosamples collected by 60,984 men ages 30-64 years, at study entry. Within 2.5 years, 183 deaths from HCC had occurred. Each HCC case was matched with 5 controls and compared for items on the questionnaire. In addition to chronic hepatitis B virus (HBV) infection, the significant risk factors were: Occupation (peasant), corn consumption (in the 1970s), family history of HCC, and history of an episode of acute hepatitis as an adult. HBV, consumption of aflatoxins, a genetic factor, and possibly a second hepatitis virus infection contribute to the risk of HCC.

KW - Aflatoxin

KW - Genetic susceptibility

KW - Hepatitis B virus

KW - Hepatocellular carcinoma

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ER -

Viral, host and environmental risk factors for hepatocellular carcinoma: A prospective study in Haimen city, China

Abstract

Keywords

ASJC Scopus subject areas

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