Viral, host and environmental risk factors for hepatocellular carcinoma: A prospective study in Haimen city, China

W. Thomas London, Alison A. Evans, Katherine Mcglynn, Kenneth Buetow, Pin G. An, Long Long Gao, Edward Lustbader, Eric Ross, Gong Chao Chen, Fu Min Shen

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

To identify specific environmental, viral, and genetic risk factors for hepatocellular carcinoma (HCC) and the interaction of such factors, we are conducting a prospective study in a high-incidence area of China. Questionnaires were completed and biosamples collected by 60,984 men ages 30-64 years, at study entry. Within 2.5 years, 183 deaths from HCC had occurred. Each HCC case was matched with 5 controls and compared for items on the questionnaire. In addition to chronic hepatitis B virus (HBV) infection, the significant risk factors were: Occupation (peasant), corn consumption (in the 1970s), family history of HCC, and history of an episode of acute hepatitis as an adult. HBV, consumption of aflatoxins, a genetic factor, and possibly a second hepatitis virus infection contribute to the risk of HCC.

Original languageEnglish (US)
Pages (from-to)155-161
Number of pages7
JournalIntervirology
Volume38
Issue number3-4
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Keywords

  • Aflatoxin
  • Genetic susceptibility
  • Hepatitis B virus
  • Hepatocellular carcinoma

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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    London, W. T., Evans, A. A., Mcglynn, K., Buetow, K., An, P. G., Gao, L. L., Lustbader, E., Ross, E., Chen, G. C., & Shen, F. M. (1995). Viral, host and environmental risk factors for hepatocellular carcinoma: A prospective study in Haimen city, China. Intervirology, 38(3-4), 155-161. https://doi.org/10.1159/000150426