Variability of innate immune system genes in Native American populations - Relationship with history and epidemiology

Juliana Dal Ri Lindenau, Francisco Mauro Salzano, Ana Hurtado, Kim Hill, Maria Luiza Petzl-Erler, Luiza Tamie Tsuneto, Mara Helena Hutz

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Objectives The immune system of a host, defending him/her against invading pathogens, has two main subsystems: innate immunity and acquired immunity. There are several evidences showing that Native American populations are immunologically different from non-Native populations. Our aim was to describe the variability of innate immune system genes in Native American populations. Materials and Methods We investigated heterozygozities and patterns of population differentiation (FST) of 14 polymorphisms related to the innate immune response in five Native American populations (Aché, Guarani-Kaiowá, Guarani-Ñandeva, Kaingang, and Xavante) and the results were compared with the three major world population data (YRI, CEU, and CHB) available at the 1,000 genomes database. Results Mean heterozygosities ranged between 0.241 ± 0.057 (Aché) and 0.343 ± 0.033 (Kaingang), but no significant differences were observed (Friedman test, P = 0.197). Mean heterozygosities were also not significantly different when Amerindians were pooled and compared with the 1000 genomes populations (Friedman test, P = 0.506). When the Native American populations were grouped as Amerindians, a significantly higher FST value (0.194) was observed between the Amerindian and African populations. The Ewens-Watterson neutrality test showed that these markers are not under strong selective pressure. Discussion Native American populations present similar levels of heterozygosity as those of other continents, but are different from Africans in the frequency of polymorphisms of innate immune genes. This higher differentiation is probably due to demographic processes that occurred during the out-of-Africa event.

    Original languageEnglish (US)
    Pages (from-to)722-728
    Number of pages7
    JournalAmerican Journal of Physical Anthropology
    Volume159
    Issue number4
    DOIs
    StatePublished - Apr 1 2016

    Fingerprint

    North American Indians
    epidemiology
    Immune System
    Epidemiology
    History
    history
    Population
    Genes
    immunity
    Innate Immunity
    Genome
    world population
    neutrality
    subsystem
    Adaptive Immunity
    Demography
    Databases
    event
    present

    Keywords

    • Amerindian demography
    • Amerindians
    • innate immune genes
    • natural selection
    • pathogens

    ASJC Scopus subject areas

    • Anthropology
    • Anatomy

    Cite this

    Variability of innate immune system genes in Native American populations - Relationship with history and epidemiology. / Lindenau, Juliana Dal Ri; Salzano, Francisco Mauro; Hurtado, Ana; Hill, Kim; Petzl-Erler, Maria Luiza; Tsuneto, Luiza Tamie; Hutz, Mara Helena.

    In: American Journal of Physical Anthropology, Vol. 159, No. 4, 01.04.2016, p. 722-728.

    Research output: Contribution to journalArticle

    Lindenau, Juliana Dal Ri ; Salzano, Francisco Mauro ; Hurtado, Ana ; Hill, Kim ; Petzl-Erler, Maria Luiza ; Tsuneto, Luiza Tamie ; Hutz, Mara Helena. / Variability of innate immune system genes in Native American populations - Relationship with history and epidemiology. In: American Journal of Physical Anthropology. 2016 ; Vol. 159, No. 4. pp. 722-728.
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    abstract = "Objectives The immune system of a host, defending him/her against invading pathogens, has two main subsystems: innate immunity and acquired immunity. There are several evidences showing that Native American populations are immunologically different from non-Native populations. Our aim was to describe the variability of innate immune system genes in Native American populations. Materials and Methods We investigated heterozygozities and patterns of population differentiation (FST) of 14 polymorphisms related to the innate immune response in five Native American populations (Ach{\'e}, Guarani-Kaiow{\'a}, Guarani-{\~N}andeva, Kaingang, and Xavante) and the results were compared with the three major world population data (YRI, CEU, and CHB) available at the 1,000 genomes database. Results Mean heterozygosities ranged between 0.241 ± 0.057 (Ach{\'e}) and 0.343 ± 0.033 (Kaingang), but no significant differences were observed (Friedman test, P = 0.197). Mean heterozygosities were also not significantly different when Amerindians were pooled and compared with the 1000 genomes populations (Friedman test, P = 0.506). When the Native American populations were grouped as Amerindians, a significantly higher FST value (0.194) was observed between the Amerindian and African populations. The Ewens-Watterson neutrality test showed that these markers are not under strong selective pressure. Discussion Native American populations present similar levels of heterozygosity as those of other continents, but are different from Africans in the frequency of polymorphisms of innate immune genes. This higher differentiation is probably due to demographic processes that occurred during the out-of-Africa event.",
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    AU - Lindenau, Juliana Dal Ri

    AU - Salzano, Francisco Mauro

    AU - Hurtado, Ana

    AU - Hill, Kim

    AU - Petzl-Erler, Maria Luiza

    AU - Tsuneto, Luiza Tamie

    AU - Hutz, Mara Helena

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    N2 - Objectives The immune system of a host, defending him/her against invading pathogens, has two main subsystems: innate immunity and acquired immunity. There are several evidences showing that Native American populations are immunologically different from non-Native populations. Our aim was to describe the variability of innate immune system genes in Native American populations. Materials and Methods We investigated heterozygozities and patterns of population differentiation (FST) of 14 polymorphisms related to the innate immune response in five Native American populations (Aché, Guarani-Kaiowá, Guarani-Ñandeva, Kaingang, and Xavante) and the results were compared with the three major world population data (YRI, CEU, and CHB) available at the 1,000 genomes database. Results Mean heterozygosities ranged between 0.241 ± 0.057 (Aché) and 0.343 ± 0.033 (Kaingang), but no significant differences were observed (Friedman test, P = 0.197). Mean heterozygosities were also not significantly different when Amerindians were pooled and compared with the 1000 genomes populations (Friedman test, P = 0.506). When the Native American populations were grouped as Amerindians, a significantly higher FST value (0.194) was observed between the Amerindian and African populations. The Ewens-Watterson neutrality test showed that these markers are not under strong selective pressure. Discussion Native American populations present similar levels of heterozygosity as those of other continents, but are different from Africans in the frequency of polymorphisms of innate immune genes. This higher differentiation is probably due to demographic processes that occurred during the out-of-Africa event.

    AB - Objectives The immune system of a host, defending him/her against invading pathogens, has two main subsystems: innate immunity and acquired immunity. There are several evidences showing that Native American populations are immunologically different from non-Native populations. Our aim was to describe the variability of innate immune system genes in Native American populations. Materials and Methods We investigated heterozygozities and patterns of population differentiation (FST) of 14 polymorphisms related to the innate immune response in five Native American populations (Aché, Guarani-Kaiowá, Guarani-Ñandeva, Kaingang, and Xavante) and the results were compared with the three major world population data (YRI, CEU, and CHB) available at the 1,000 genomes database. Results Mean heterozygosities ranged between 0.241 ± 0.057 (Aché) and 0.343 ± 0.033 (Kaingang), but no significant differences were observed (Friedman test, P = 0.197). Mean heterozygosities were also not significantly different when Amerindians were pooled and compared with the 1000 genomes populations (Friedman test, P = 0.506). When the Native American populations were grouped as Amerindians, a significantly higher FST value (0.194) was observed between the Amerindian and African populations. The Ewens-Watterson neutrality test showed that these markers are not under strong selective pressure. Discussion Native American populations present similar levels of heterozygosity as those of other continents, but are different from Africans in the frequency of polymorphisms of innate immune genes. This higher differentiation is probably due to demographic processes that occurred during the out-of-Africa event.

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