Using biomaterials to modulate chemotactic signaling for central nervous system repair

Kassondra Hickey; Sarah Stabenfeldt

doi:10.1088/1748-605X/aaad82

Using biomaterials to modulate chemotactic signaling for central nervous system repair

Kassondra Hickey, Sarah Stabenfeldt

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Chemotaxis enables cellular communication and movement within the body. This review focuses on exploiting chemotaxis as a tool for repair of the central nervous system (CNS) damaged from injury and/or degenerative diseases. Chemokines and factors alone may initiate repair following CNS injury/disease, but exogenous administration may enhance repair and promote regeneration. This review will discuss critical chemotactic molecules and factors that may promote neural regeneration. Additionally, this review highlights how biomaterials can impact the presentation and delivery of chemokines and growth factors to alter the regenerative response.

Original language	English (US)
Article number	044106
Journal	Biomedical Materials (Bristol)
Volume	13
Issue number	4
DOIs	https://doi.org/10.1088/1748-605X/aaad82
State	Published - Apr 27 2018

Keywords

central nervous system
chemotaxis
drug delivery
spinal cord injury
stroke
traumatic brain injury

ASJC Scopus subject areas

Bioengineering
Biomaterials
Biomedical Engineering

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10.1088/1748-605X/aaad82

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abstract = "Chemotaxis enables cellular communication and movement within the body. This review focuses on exploiting chemotaxis as a tool for repair of the central nervous system (CNS) damaged from injury and/or degenerative diseases. Chemokines and factors alone may initiate repair following CNS injury/disease, but exogenous administration may enhance repair and promote regeneration. This review will discuss critical chemotactic molecules and factors that may promote neural regeneration. Additionally, this review highlights how biomaterials can impact the presentation and delivery of chemokines and growth factors to alter the regenerative response.",

keywords = "central nervous system, chemotaxis, drug delivery, spinal cord injury, stroke, traumatic brain injury",

author = "Kassondra Hickey and Sarah Stabenfeldt",

note = "Funding Information: The authors acknowledge Amanda Witten for assistance with graphic design. This work was supported by NSF CBET 1454282 (SES) and NIH NICHD 1DP2HD084067 (SES). Funding Information: This work was supported by NSF CBET1454282 (SES) andNIHNICHD1DP2HD084067 (SES). Publisher Copyright: {\textcopyright} 2018 IOP Publishing Ltd.",

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N2 - Chemotaxis enables cellular communication and movement within the body. This review focuses on exploiting chemotaxis as a tool for repair of the central nervous system (CNS) damaged from injury and/or degenerative diseases. Chemokines and factors alone may initiate repair following CNS injury/disease, but exogenous administration may enhance repair and promote regeneration. This review will discuss critical chemotactic molecules and factors that may promote neural regeneration. Additionally, this review highlights how biomaterials can impact the presentation and delivery of chemokines and growth factors to alter the regenerative response.

AB - Chemotaxis enables cellular communication and movement within the body. This review focuses on exploiting chemotaxis as a tool for repair of the central nervous system (CNS) damaged from injury and/or degenerative diseases. Chemokines and factors alone may initiate repair following CNS injury/disease, but exogenous administration may enhance repair and promote regeneration. This review will discuss critical chemotactic molecules and factors that may promote neural regeneration. Additionally, this review highlights how biomaterials can impact the presentation and delivery of chemokines and growth factors to alter the regenerative response.

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KW - stroke

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Using biomaterials to modulate chemotactic signaling for central nervous system repair

Abstract

Keywords

ASJC Scopus subject areas

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