Using biomaterials to modulate chemotactic signaling for central nervous system repair

Kassondra Hickey, Sarah Stabenfeldt

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Chemotaxis enables cellular communication and movement within the body. This review focuses on exploiting chemotaxis as a tool for repair of the central nervous system (CNS) damaged from injury and/or degenerative diseases. Chemokines and factors alone may initiate repair following CNS injury/disease, but exogenous administration may enhance repair and promote regeneration. This review will discuss critical chemotactic molecules and factors that may promote neural regeneration. Additionally, this review highlights how biomaterials can impact the presentation and delivery of chemokines and growth factors to alter the regenerative response.

Original languageEnglish (US)
Article number044106
JournalBiomedical Materials (Bristol)
Volume13
Issue number4
DOIs
StatePublished - Apr 27 2018

Keywords

  • central nervous system
  • chemotaxis
  • drug delivery
  • spinal cord injury
  • stroke
  • traumatic brain injury

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Using biomaterials to modulate chemotactic signaling for central nervous system repair'. Together they form a unique fingerprint.

Cite this