Urinary sugars—a biomarker of total sugars intake

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Measurement error in self-reported sugars intake may explain the lack of consistency in the epidemiologic evidence on the association between sugars and disease risk. This review describes the development and applications of a biomarker of sugars intake, informs its future use and recommends directions for future research. Recently, 24 h urinary sucrose and fructose were suggested as a predictive biomarker for total sugars intake, based on findings from three highly controlled feeding studies conducted in the United Kingdom. From this work, a calibration equation for the biomarker that provides an unbiased measure of sugars intake was generated that has since been used in two US-based studies with free-living individuals to assess measurement error in dietary self-reports and to develop regression calibration equations that could be used in future diet-disease analyses. Further applications of the biomarker include its use as a surrogate measure of intake in diet-disease association studies. Although this biomarker has great potential and exhibits favorable characteristics, available data come from a few controlled studies with limited sample sizes conducted in the UK. Larger feeding studies conducted in different populations are needed to further explore biomarker characteristics and stability of its biases, compare its performance, and generate a unique, or population-specific biomarker calibration equations to be applied in future studies. A validated sugars biomarker is critical for informed interpretation of sugars-disease association studies.

Original languageEnglish (US)
Pages (from-to)5816-5833
Number of pages18
JournalNutrients
Volume7
Issue number7
DOIs
StatePublished - Jul 15 2015

Fingerprint

biomarkers
Biomarkers
sugars
Calibration
calibration
Diet
diet-related diseases
Fructose
Sample Size
Self Report
Population
United Kingdom
Sucrose
fructose
sucrose
diet

Keywords

  • Calibration
  • Diet
  • Fructose
  • Measurement error
  • Predictive biomarker
  • Sucrose
  • Sugars
  • Urine
  • Validation

ASJC Scopus subject areas

  • Food Science

Cite this

Urinary sugars—a biomarker of total sugars intake. / Tasevska, Natasha.

In: Nutrients, Vol. 7, No. 7, 15.07.2015, p. 5816-5833.

Research output: Contribution to journalArticle

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