Uncover genetic interactions in Caenorhabditis elegans by RNA interference

Angelo Fortunato, Andrew G. Fraser

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

RNA-mediated interference (RNAi) has emerged recently as one of the most powerful functional genomics tools. RNAi has been particularly effective in the nematode worm C. elegans where RNAi has been used to analyse the loss-of-function phenotypes of almost all predicted genes. In this review, we illustrate how RNAi has been used to analyse gene function in C. elegans as well as pointing to some future directions for using RNAi to examine genetic interactions in a systematic manner.

Original languageEnglish (US)
Pages (from-to)299-307
Number of pages9
JournalBioscience Reports
Volume25
Issue number5-6
DOIs
StatePublished - Oct 1 2005
Externally publishedYes

Keywords

  • C. elegans
  • Genetic network
  • Genome
  • RNA interference
  • Synthetic phenotype

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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