Uncover genetic interactions in Caenorhabditis elegans by RNA interference

Angelo Fortunato; Andrew G. Fraser

doi:10.1007/s10540-005-2892-7

Uncover genetic interactions in Caenorhabditis elegans by RNA interference

Angelo Fortunato, Andrew G. Fraser

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

RNA-mediated interference (RNAi) has emerged recently as one of the most powerful functional genomics tools. RNAi has been particularly effective in the nematode worm C. elegans where RNAi has been used to analyse the loss-of-function phenotypes of almost all predicted genes. In this review, we illustrate how RNAi has been used to analyse gene function in C. elegans as well as pointing to some future directions for using RNAi to examine genetic interactions in a systematic manner.

Original language	English (US)
Pages (from-to)	299-307
Number of pages	9
Journal	Bioscience Reports
Volume	25
Issue number	5-6
DOIs	https://doi.org/10.1007/s10540-005-2892-7
State	Published - Oct 2005
Externally published	Yes

Keywords

C. elegans
Genetic network
Genome
RNA interference
Synthetic phenotype

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1007/s10540-005-2892-7

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abstract = "RNA-mediated interference (RNAi) has emerged recently as one of the most powerful functional genomics tools. RNAi has been particularly effective in the nematode worm C. elegans where RNAi has been used to analyse the loss-of-function phenotypes of almost all predicted genes. In this review, we illustrate how RNAi has been used to analyse gene function in C. elegans as well as pointing to some future directions for using RNAi to examine genetic interactions in a systematic manner.",

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AU - Fraser, Andrew G.

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AB - RNA-mediated interference (RNAi) has emerged recently as one of the most powerful functional genomics tools. RNAi has been particularly effective in the nematode worm C. elegans where RNAi has been used to analyse the loss-of-function phenotypes of almost all predicted genes. In this review, we illustrate how RNAi has been used to analyse gene function in C. elegans as well as pointing to some future directions for using RNAi to examine genetic interactions in a systematic manner.

KW - C. elegans

KW - Genetic network

KW - Genome

KW - RNA interference

KW - Synthetic phenotype

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ER -

Uncover genetic interactions in Caenorhabditis elegans by RNA interference

Abstract

Keywords

ASJC Scopus subject areas

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