TY - GEN
T1 - Ultrasound induced increase in excitability of single neurons
AU - Khraiche, Massoud L.
AU - Phillips, William B.
AU - Jackson, Nathan
AU - Muthuswamy, Jitendran
PY - 2008
Y1 - 2008
N2 - The aim of this study was to carefully assess the level of modulation in electrical excitability of single neurons with the application of high frequency ultrasound. High frequency tone bursts of ultrasound have been shown to dramatically increase the spike frequency of primary hippocampal neurons in culture. In addition, these ultrasonic bursts also induce silent or still developing neurons to fire. Results indicate that the increase in excitability is largely mediated by mechanical effects and not thermal effects of ultrasound. Future studies on culture models exposed to varying ultrasound protocols may provide insight into the feasibility of using ultrasound as a means for neurostimulation studies conducted on brain slice and in vivo models.
AB - The aim of this study was to carefully assess the level of modulation in electrical excitability of single neurons with the application of high frequency ultrasound. High frequency tone bursts of ultrasound have been shown to dramatically increase the spike frequency of primary hippocampal neurons in culture. In addition, these ultrasonic bursts also induce silent or still developing neurons to fire. Results indicate that the increase in excitability is largely mediated by mechanical effects and not thermal effects of ultrasound. Future studies on culture models exposed to varying ultrasound protocols may provide insight into the feasibility of using ultrasound as a means for neurostimulation studies conducted on brain slice and in vivo models.
UR - http://www.scopus.com/inward/record.url?scp=61849112295&partnerID=8YFLogxK
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U2 - 10.1109/iembs.2008.4650147
DO - 10.1109/iembs.2008.4650147
M3 - Conference contribution
C2 - 19163650
AN - SCOPUS:61849112295
SN - 9781424418152
T3 - Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"
SP - 4246
EP - 4249
BT - Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
PB - IEEE Computer Society
T2 - 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
Y2 - 20 August 2008 through 25 August 2008
ER -