Ultrasound induced increase in excitability of single neurons

Massoud L. Khraiche, William B. Phillips, Nathan Jackson, Jitendran Muthuswamy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Scopus citations

Abstract

The aim of this study was to carefully assess the level of modulation in electrical excitability of single neurons with the application of high frequency ultrasound. High frequency tone bursts of ultrasound have been shown to dramatically increase the spike frequency of primary hippocampal neurons in culture. In addition, these ultrasonic bursts also induce silent or still developing neurons to fire. Results indicate that the increase in excitability is largely mediated by mechanical effects and not thermal effects of ultrasound. Future studies on culture models exposed to varying ultrasound protocols may provide insight into the feasibility of using ultrasound as a means for neurostimulation studies conducted on brain slice and in vivo models.

Original languageEnglish (US)
Title of host publicationProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"
Pages4246-4249
Number of pages4
Publication statusPublished - 2008
Event30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - Vancouver, BC, Canada
Duration: Aug 20 2008Aug 25 2008

Other

Other30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
CountryCanada
CityVancouver, BC
Period8/20/088/25/08

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ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Khraiche, M. L., Phillips, W. B., Jackson, N., & Muthuswamy, J. (2008). Ultrasound induced increase in excitability of single neurons. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology" (pp. 4246-4249). [4650147]