Ultrasonically-assisted intracortical microstimulation of the rat

William B. Phillips, Patrick J. Larson, Bruce C. Towe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

High frequency tone bursts of ultrasound are capable of increasing the sensitivity of rat motor cortex to electrical stimulation. In this study, 11.75 MHz ultrasound prestimuli were delivered to the forelimb motor region of the rat cortex followed by an electrical pulse train to assess changes in cortical activation. The temporal peak intensity of the ultrasound delivered to the brain ranged from 100 to 150W/cm 2. Tone bursts of 10 to 50ms in duration were delivered once per second over periods of 30 to 240 seconds. The intracortical microstimulation (ICMS) current needed for forepaw motor response decreased by as much as 40% when applying 50 ms ultrasound pulses. Brain excitability changes were seen with a thermal index (TI) as low as 2.0. Ultrasound application alone was not able to induce motor responses.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages4217-4220
Number of pages4
Volume26 VI
StatePublished - 2004
EventConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States
Duration: Sep 1 2004Sep 5 2004

Other

OtherConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004
CountryUnited States
CitySan Francisco, CA
Period9/1/049/5/04

Keywords

  • Intracortical microstimulation
  • Neural engineering
  • Rat motor cortex
  • Ultrasound

ASJC Scopus subject areas

  • Bioengineering

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