Ultrasensitive label-free aptamer-based electronic detection

Yun Xiang, Mingyi Xie, Ralph Bash, Julian Chen, Joseph Wang

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

(Figure Presented) The highs and lows of proteins: A dramatically amplified aptamer-based bioelectronic assay has been developed that allows the ultrasensitive measurement of thrombin down to the femtomolar level. This label-free electronic detection of thrombin takes advantage of the intrinsic electroactivity of a second aptamer with guanine bases, and the enormous amplification feature of the polymerase chain reaction (PCR, see picture).

Original languageEnglish (US)
Pages (from-to)9054-9056
Number of pages3
JournalAngewandte Chemie - International Edition
Volume46
Issue number47
DOIs
StatePublished - 2007

Fingerprint

Polymerase chain reaction
Thrombin
Amplification
Labels
Assays
Proteins
Staphylococcal Protein A
Guanine

Keywords

  • Aptamers
  • Bioelectronics
  • Guanine
  • Polymerase chain reaction
  • Proteins

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Ultrasensitive label-free aptamer-based electronic detection. / Xiang, Yun; Xie, Mingyi; Bash, Ralph; Chen, Julian; Wang, Joseph.

In: Angewandte Chemie - International Edition, Vol. 46, No. 47, 2007, p. 9054-9056.

Research output: Contribution to journalArticle

Xiang, Yun ; Xie, Mingyi ; Bash, Ralph ; Chen, Julian ; Wang, Joseph. / Ultrasensitive label-free aptamer-based electronic detection. In: Angewandte Chemie - International Edition. 2007 ; Vol. 46, No. 47. pp. 9054-9056.
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