Abstract

We report an ultra-thin silicone membrane array to simultaneously discern the presence of cancerous cells in as many as 16 samples from multiple individuals. This high throughput parallel array relies on the intrinsic and specific biophysical properties of cancerous cells to induce deformation, or 'wrinkling' on the arrayed membrane. In contrast, non-cancerous cells fail to generate these membrane wrinkles. We evaluated an initial pilot study to test clinical urine samples from patients at a high risk for bladder cancer. We also expanded the functionality of the ultra-thin membrane array beyond bladder cancer toward the screening of cervical cancer. This screening array has the potential to be deployed at the point-of-care to improve throughput compared to sequential analysis by individual membranes and may be able to enhance reliability and accuracy by coordinating controls for false results concurrently.

Original languageEnglish (US)
Title of host publicationMEMS 2016 - 29th IEEE International Conference on Micro Electro Mechanical Systems
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages419-422
Number of pages4
ISBN (Electronic)9781509019731
DOIs
StatePublished - Feb 26 2016
Event29th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2016 - Shanghai, China
Duration: Jan 24 2016Jan 28 2016

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume2016-February
ISSN (Print)1084-6999

Other

Other29th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2016
CountryChina
CityShanghai
Period1/24/161/28/16

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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