Type IV collagens regulate BMP signalling in Drosophila

Xiaomeng Wang, Robin Harris, Laura J. Bayston, Hilary L. Ashe

Research output: Contribution to journalArticle

196 Citations (Scopus)

Abstract

Dorsal-ventral patterning in vertebrate and invertebrate embryos is mediated by a conserved system of secreted proteins that establishes a bone morphogenetic protein (BMP) gradient. Although the Drosophila embryonic Decapentaplegic (Dpp) gradient has served as a model to understand how morphogen gradients are established, no role for the extracellular matrix has been previously described. Here we show that type IV collagen extracellular matrix proteins bind Dpp and regulate its signalling in both the Drosophila embryo and ovary. We provide evidence that the interaction between Dpp and type IV collagen augments Dpp signalling in the embryo by promoting gradient formation, yet it restricts the signalling range in the ovary through sequestration of the Dpp ligand. Together, these results identify a critical function of type IV collagens in modulating Dpp in the extracellular space during Drosophila development. On the basis of our findings that human type IV collagen binds BMP4, we predict that this role of type IV collagens will be conserved.

Original languageEnglish (US)
Pages (from-to)72-77
Number of pages6
JournalNature
Volume455
Issue number7209
DOIs
StatePublished - Sep 4 2008
Externally publishedYes

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Bone Morphogenetic Proteins
Collagen Type IV
Drosophila
Embryonic Structures
Ovary
Extracellular Matrix Proteins
Extracellular Space
Invertebrates
Extracellular Matrix
Vertebrates
Ligands
Proteins

ASJC Scopus subject areas

  • General

Cite this

Type IV collagens regulate BMP signalling in Drosophila. / Wang, Xiaomeng; Harris, Robin; Bayston, Laura J.; Ashe, Hilary L.

In: Nature, Vol. 455, No. 7209, 04.09.2008, p. 72-77.

Research output: Contribution to journalArticle

Wang, X, Harris, R, Bayston, LJ & Ashe, HL 2008, 'Type IV collagens regulate BMP signalling in Drosophila', Nature, vol. 455, no. 7209, pp. 72-77. https://doi.org/10.1038/nature07214
Wang, Xiaomeng ; Harris, Robin ; Bayston, Laura J. ; Ashe, Hilary L. / Type IV collagens regulate BMP signalling in Drosophila. In: Nature. 2008 ; Vol. 455, No. 7209. pp. 72-77.
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