Abstract
DNA migration in topologically structured microchannels with periodic cavities is investigated experimentally and with Brownian dynamics simulations of a simple bead-spring model. The results are in very good agreement with one another. In particular, the experimentally observed migration order oλ- and T2-DNA molecules is reproduced by the simulations. The simulation data indicate that the mobility may depend on the chain length in a nonmonotonic way at high electric fields. This is found to be the signature of a nonequilibrium bistability between two different migration states, a slow one and a fast one. The latter can also be observed experimentally under appropriate conditions.
Original language | English (US) |
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Article number | 011905 |
Journal | Physical Review E - Statistical, Nonlinear, and Soft Matter Physics |
Volume | 71 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2005 |
Externally published | Yes |
ASJC Scopus subject areas
- Statistical and Nonlinear Physics
- Statistics and Probability
- Condensed Matter Physics