Two-state migration of DNA in a structured microchannel

Martin Streek, Friederike Schmid, Thanh Tu Duong, Dario Anselmetti, Alexandra Ros

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

DNA migration in topologically structured microchannels with periodic cavities is investigated experimentally and with Brownian dynamics simulations of a simple bead-spring model. The results are in very good agreement with one another. In particular, the experimentally observed migration order oλ- and T2-DNA molecules is reproduced by the simulations. The simulation data indicate that the mobility may depend on the chain length in a nonmonotonic way at high electric fields. This is found to be the signature of a nonequilibrium bistability between two different migration states, a slow one and a fast one. The latter can also be observed experimentally under appropriate conditions.

Original languageEnglish (US)
Article number011905
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume71
Issue number1
DOIs
StatePublished - Jan 2005
Externally publishedYes

Fingerprint

Microchannel
microchannels
Migration
deoxyribonucleic acid
DNA
Brownian Dynamics
Bistability
data simulation
Dynamic Simulation
beads
Non-equilibrium
Electric Field
Cavity
Simulation
Signature
simulation
signatures
Molecules
cavities
electric fields

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Condensed Matter Physics
  • Statistical and Nonlinear Physics
  • Mathematical Physics
  • Medicine(all)

Cite this

Two-state migration of DNA in a structured microchannel. / Streek, Martin; Schmid, Friederike; Duong, Thanh Tu; Anselmetti, Dario; Ros, Alexandra.

In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, Vol. 71, No. 1, 011905, 01.2005.

Research output: Contribution to journalArticle

Streek, Martin ; Schmid, Friederike ; Duong, Thanh Tu ; Anselmetti, Dario ; Ros, Alexandra. / Two-state migration of DNA in a structured microchannel. In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 2005 ; Vol. 71, No. 1.
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