Tumour oxygen dynamics measured simultaneously by near-infrared spectroscopy and 19F magnetic resonance imaging in rats

Mengna Xia, Vikram Kodibagkar, Hanli Liu, Ralph P. Mason

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Simultaneous near-infrared spectroscopy (NIRS) and magnetic resonance imaging (MRI) were used to investigate the correlation between tumour vascular oxygenation and tissue oxygen tension dynamics in rat breast 13762NF tumours with respect to hyperoxic gas breathing. NIRS directly detected global variations in the oxygenated haemoglobin concentration (Δ[HbO 2]) within tumours and oxygen tension (pO2) maps were achieved using 19F MRI of the reporter molecule hexafluorobenzene. Multiple correlations were examined between rates and magnitudes of vascular (Δ[HbO2]) and tissue (pO2) responses. Significant correlations were found between response to oxygen and carbogen breathing using either modality. Comparison of results for the two methods showed a correlation between the vascular perfusion rate ratio and the mean pO2 values (R2 > 0.7). The initial rates of increase of Δ[HbO 2] and the slope of dynamic pO2 response, d(pO 2)/dt, of well-oxygenated voxels in response to hyperoxic challenge were also correlated. These results demonstrate the feasibility of simultaneous measurements using NIRS and MRI. As expected, the rate of pO2 response to oxygen is primarily dependent upon the well perfused rather than poorly perfused vasculature.

Original languageEnglish (US)
Pages (from-to)45-60
Number of pages16
JournalPhysics in Medicine and Biology
Volume51
Issue number1
DOIs
StatePublished - Jan 7 2006
Externally publishedYes

Fingerprint

Near infrared spectroscopy
Near-Infrared Spectroscopy
Magnetic resonance
rats
magnetic resonance
Rats
Tumors
tumors
oxygen tension
infrared spectroscopy
Magnetic Resonance Imaging
Oxygen
Blood Vessels
Imaging techniques
oxygen
breathing
Neoplasms
Respiration
oxygen breathing
Tissue

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Tumour oxygen dynamics measured simultaneously by near-infrared spectroscopy and 19F magnetic resonance imaging in rats. / Xia, Mengna; Kodibagkar, Vikram; Liu, Hanli; Mason, Ralph P.

In: Physics in Medicine and Biology, Vol. 51, No. 1, 07.01.2006, p. 45-60.

Research output: Contribution to journalArticle

@article{230721922ab8466f9618d9e03a5acc99,
title = "Tumour oxygen dynamics measured simultaneously by near-infrared spectroscopy and 19F magnetic resonance imaging in rats",
abstract = "Simultaneous near-infrared spectroscopy (NIRS) and magnetic resonance imaging (MRI) were used to investigate the correlation between tumour vascular oxygenation and tissue oxygen tension dynamics in rat breast 13762NF tumours with respect to hyperoxic gas breathing. NIRS directly detected global variations in the oxygenated haemoglobin concentration (Δ[HbO 2]) within tumours and oxygen tension (pO2) maps were achieved using 19F MRI of the reporter molecule hexafluorobenzene. Multiple correlations were examined between rates and magnitudes of vascular (Δ[HbO2]) and tissue (pO2) responses. Significant correlations were found between response to oxygen and carbogen breathing using either modality. Comparison of results for the two methods showed a correlation between the vascular perfusion rate ratio and the mean pO2 values (R2 > 0.7). The initial rates of increase of Δ[HbO 2] and the slope of dynamic pO2 response, d(pO 2)/dt, of well-oxygenated voxels in response to hyperoxic challenge were also correlated. These results demonstrate the feasibility of simultaneous measurements using NIRS and MRI. As expected, the rate of pO2 response to oxygen is primarily dependent upon the well perfused rather than poorly perfused vasculature.",
author = "Mengna Xia and Vikram Kodibagkar and Hanli Liu and Mason, {Ralph P.}",
year = "2006",
month = "1",
day = "7",
doi = "10.1088/0031-9155/51/1/004",
language = "English (US)",
volume = "51",
pages = "45--60",
journal = "Physics in Medicine and Biology",
issn = "0031-9155",
publisher = "IOP Publishing Ltd.",
number = "1",

}

TY - JOUR

T1 - Tumour oxygen dynamics measured simultaneously by near-infrared spectroscopy and 19F magnetic resonance imaging in rats

AU - Xia, Mengna

AU - Kodibagkar, Vikram

AU - Liu, Hanli

AU - Mason, Ralph P.

PY - 2006/1/7

Y1 - 2006/1/7

N2 - Simultaneous near-infrared spectroscopy (NIRS) and magnetic resonance imaging (MRI) were used to investigate the correlation between tumour vascular oxygenation and tissue oxygen tension dynamics in rat breast 13762NF tumours with respect to hyperoxic gas breathing. NIRS directly detected global variations in the oxygenated haemoglobin concentration (Δ[HbO 2]) within tumours and oxygen tension (pO2) maps were achieved using 19F MRI of the reporter molecule hexafluorobenzene. Multiple correlations were examined between rates and magnitudes of vascular (Δ[HbO2]) and tissue (pO2) responses. Significant correlations were found between response to oxygen and carbogen breathing using either modality. Comparison of results for the two methods showed a correlation between the vascular perfusion rate ratio and the mean pO2 values (R2 > 0.7). The initial rates of increase of Δ[HbO 2] and the slope of dynamic pO2 response, d(pO 2)/dt, of well-oxygenated voxels in response to hyperoxic challenge were also correlated. These results demonstrate the feasibility of simultaneous measurements using NIRS and MRI. As expected, the rate of pO2 response to oxygen is primarily dependent upon the well perfused rather than poorly perfused vasculature.

AB - Simultaneous near-infrared spectroscopy (NIRS) and magnetic resonance imaging (MRI) were used to investigate the correlation between tumour vascular oxygenation and tissue oxygen tension dynamics in rat breast 13762NF tumours with respect to hyperoxic gas breathing. NIRS directly detected global variations in the oxygenated haemoglobin concentration (Δ[HbO 2]) within tumours and oxygen tension (pO2) maps were achieved using 19F MRI of the reporter molecule hexafluorobenzene. Multiple correlations were examined between rates and magnitudes of vascular (Δ[HbO2]) and tissue (pO2) responses. Significant correlations were found between response to oxygen and carbogen breathing using either modality. Comparison of results for the two methods showed a correlation between the vascular perfusion rate ratio and the mean pO2 values (R2 > 0.7). The initial rates of increase of Δ[HbO 2] and the slope of dynamic pO2 response, d(pO 2)/dt, of well-oxygenated voxels in response to hyperoxic challenge were also correlated. These results demonstrate the feasibility of simultaneous measurements using NIRS and MRI. As expected, the rate of pO2 response to oxygen is primarily dependent upon the well perfused rather than poorly perfused vasculature.

UR - http://www.scopus.com/inward/record.url?scp=29144475774&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29144475774&partnerID=8YFLogxK

U2 - 10.1088/0031-9155/51/1/004

DO - 10.1088/0031-9155/51/1/004

M3 - Article

C2 - 16357430

AN - SCOPUS:29144475774

VL - 51

SP - 45

EP - 60

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

IS - 1

ER -