Abstract
The use of immune checkpoint inhibitors is becoming more commonplace in clinical trials across the nation. Two important factors in the tumour-immune response are the checkpoint protein programmed death-1 (PD-1) and its ligand PD-L1. We propose a mathematical tumour-immune model using a system of ordinary differential equations to study dynamics with and without the use of anti-PD-1. A sensitivity analysis is conducted, and series of simulations are performed to investigate the effects of intermittent and continuous treatments on the tumour-immune dynamics. We consider the system without the anti-PD-1 drug to conduct a mathematical analysis to determine the stability of the tumour-free and tumorous equilibria. Through simulations, we found that a normally functioning immune system may control tumour. We observe treatment with anti-PD-1 alone may not be sufficient to eradicate tumour cells. Therefore, it may be beneficial to combine single agent treatments with additional therapies to obtain a better antitumour response.
Original language | English (US) |
---|---|
Pages (from-to) | S137-S159 |
Journal | Letters in Biomathematics |
Volume | 5 |
Issue number | sup1 |
DOIs | |
State | Published - Jun 30 2018 |
Keywords
- Immunotherapy
- PD-1
- PD-L1
- anti-PD-1
- checkpoint inhibitor
- mathematical oncology
- tumour
- tumour/immune model
ASJC Scopus subject areas
- Statistics and Probability
- Biochemistry, Genetics and Molecular Biology (miscellaneous)
- Applied Mathematics