Abstract
Individually, tumor necrosis factor (TNF) and the various interferons frequently display strong antiviral activities. Certain combinations of these cytokines, however, induce a synergistic antiviral state which is distinct from that induced by either one alone. This novel synergistic antiviral state likely occurs through several possible mechanisms, involves multiple signaling pathways, and inhibits a wider range of viruses than the individual cytokines alone. While underappreciated when first discovered, this synergistic phenomenon is proving to be of a much broader scope than initially thought. More work is needed to refine our understanding of this observation and its physiological implications for anti-pathogen responses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 378-383 |
| Number of pages | 6 |
| Journal | Current Opinion in Microbiology |
| Volume | 11 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 1 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Microbiology
- Microbiology (medical)
- Infectious Diseases
Cite this
Tumor necrosis factor and interferon : cytokines in harmony. / Bartee, Eric; Mohamed, Mohamed R.; McFadden, Douglas.
In: Current Opinion in Microbiology, Vol. 11, No. 4, 01.08.2008, p. 378-383.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Tumor necrosis factor and interferon
T2 - cytokines in harmony
AU - Bartee, Eric
AU - Mohamed, Mohamed R.
AU - McFadden, Douglas
PY - 2008/8/1
Y1 - 2008/8/1
N2 - Individually, tumor necrosis factor (TNF) and the various interferons frequently display strong antiviral activities. Certain combinations of these cytokines, however, induce a synergistic antiviral state which is distinct from that induced by either one alone. This novel synergistic antiviral state likely occurs through several possible mechanisms, involves multiple signaling pathways, and inhibits a wider range of viruses than the individual cytokines alone. While underappreciated when first discovered, this synergistic phenomenon is proving to be of a much broader scope than initially thought. More work is needed to refine our understanding of this observation and its physiological implications for anti-pathogen responses.
AB - Individually, tumor necrosis factor (TNF) and the various interferons frequently display strong antiviral activities. Certain combinations of these cytokines, however, induce a synergistic antiviral state which is distinct from that induced by either one alone. This novel synergistic antiviral state likely occurs through several possible mechanisms, involves multiple signaling pathways, and inhibits a wider range of viruses than the individual cytokines alone. While underappreciated when first discovered, this synergistic phenomenon is proving to be of a much broader scope than initially thought. More work is needed to refine our understanding of this observation and its physiological implications for anti-pathogen responses.
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UR - http://www.scopus.com/inward/citedby.url?scp=48749096246&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2008.05.015
DO - 10.1016/j.mib.2008.05.015
M3 - Review article
VL - 11
SP - 378
EP - 383
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
SN - 1369-5274
IS - 4
ER -