Tumor necrosis factor and interferon

cytokines in harmony

Eric Bartee, Mohamed R. Mohamed, Douglas McFadden

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

Individually, tumor necrosis factor (TNF) and the various interferons frequently display strong antiviral activities. Certain combinations of these cytokines, however, induce a synergistic antiviral state which is distinct from that induced by either one alone. This novel synergistic antiviral state likely occurs through several possible mechanisms, involves multiple signaling pathways, and inhibits a wider range of viruses than the individual cytokines alone. While underappreciated when first discovered, this synergistic phenomenon is proving to be of a much broader scope than initially thought. More work is needed to refine our understanding of this observation and its physiological implications for anti-pathogen responses.

Original languageEnglish (US)
Pages (from-to)378-383
Number of pages6
JournalCurrent Opinion in Microbiology
Volume11
Issue number4
DOIs
StatePublished - Aug 1 2008
Externally publishedYes

Fingerprint

Interferons
Antiviral Agents
Tumor Necrosis Factor-alpha
Cytokines
Viruses

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Tumor necrosis factor and interferon : cytokines in harmony. / Bartee, Eric; Mohamed, Mohamed R.; McFadden, Douglas.

In: Current Opinion in Microbiology, Vol. 11, No. 4, 01.08.2008, p. 378-383.

Research output: Contribution to journalReview article

Bartee, Eric ; Mohamed, Mohamed R. ; McFadden, Douglas. / Tumor necrosis factor and interferon : cytokines in harmony. In: Current Opinion in Microbiology. 2008 ; Vol. 11, No. 4. pp. 378-383.
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