Trophic factors for Parkinson's disease: To live or let die

C. Warren Olanow; Raymond T. Bartus; Laura A. Volpicelli-Daley; Jeffrey H. Kordower

doi:10.1002/mds.26426

Trophic factors for Parkinson's disease: To live or let die

C. Warren Olanow, Raymond T. Bartus, Laura A. Volpicelli-Daley, Jeffrey H. Kordower

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Trophic factors show great promise in laboratory studies as potential therapies for PD. However, multiple double-blind, clinical trials have failed to show benefits in comparison to a placebo control. This article will review the scientific rationale for testing trophic factors in PD, the results of the different clinical trials that have been performed to date, and the possible explanations for these failed outcomes. We will also consider future directions and the likelihood that trophic factors will become a viable therapy for patients with PD.

Original language	English (US)
Pages (from-to)	1715-1724
Number of pages	10
Journal	Movement Disorders
Volume	30
Issue number	13
DOIs	https://doi.org/10.1002/mds.26426
State	Published - Nov 1 2015
Externally published	Yes

Keywords

Trophic Factors; Parkinson's Disease; GDNF; Neurturin

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.26426

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title = "Trophic factors for Parkinson's disease: To live or let die",

abstract = "Trophic factors show great promise in laboratory studies as potential therapies for PD. However, multiple double-blind, clinical trials have failed to show benefits in comparison to a placebo control. This article will review the scientific rationale for testing trophic factors in PD, the results of the different clinical trials that have been performed to date, and the possible explanations for these failed outcomes. We will also consider future directions and the likelihood that trophic factors will become a viable therapy for patients with PD.",

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author = "Olanow, {C. Warren} and Bartus, {Raymond T.} and Volpicelli-Daley, {Laura A.} and Kordower, {Jeffrey H.}",

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AU - Kordower, Jeffrey H.

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AB - Trophic factors show great promise in laboratory studies as potential therapies for PD. However, multiple double-blind, clinical trials have failed to show benefits in comparison to a placebo control. This article will review the scientific rationale for testing trophic factors in PD, the results of the different clinical trials that have been performed to date, and the possible explanations for these failed outcomes. We will also consider future directions and the likelihood that trophic factors will become a viable therapy for patients with PD.

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Trophic factors for Parkinson's disease: To live or let die

Abstract

Keywords

ASJC Scopus subject areas

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