Treatment with Focused Ultrasound Waves Softens the Rat Cervix During Pregnancy

Daishen Luo, Heng Yu, Robert E. Garfield, Shao Qing Shi, Bruce Towe

Research output: Contribution to journalArticle

Abstract

Application of focused ultrasound stimulation (FUS) to the rat cervix during pregnancy has significant physiologic effects. One-millisecond-long pulses of 680-kHz ultrasound with a repetition frequency of 25 Hz, at ISPTA (spatial-peak, temporal-average intensity) of 1, 2 and 4W/cm2, were applied to the rat abdomen over the cervix. FUS produced a significant change in cervical elasticity known as softening, which is part of the ripening process, comparable to the degree seen just before delivery. Timed-pregnant Sprague-Dawley rats (n = 40) were used. During gestation, the FUS system was applied to the cervix for variable times up to 1 h. Daily measurements of cervix light-induced florescence were made to estimate changes in softening. In addition, cervical stretch estimates of softening were made of isolated cervices of control and FUS-treated rats to measure distensiblity. The ultrasound power with ISPPA (spatial-peak, pulse-average intensity) of 40 W/cm2 was considered tolerable ; the U.S. Food and Drug Administration regulatory limit is 190 W/cm2 for both the body periphery and the fetus. This is the first report of alterations induced by ultrasound in the connective tissue of the cervix and suggests the therapeutic application of ultrasound for the facilitation of labor and delivery.

Original languageEnglish (US)
Pages (from-to)2107-2112
Number of pages6
JournalUltrasound in Medicine and Biology
Volume40
Issue number9
DOIs
StatePublished - 2014

Fingerprint

pregnancy
stimulation
Cervix Uteri
rats
softening
Pregnancy
delivery
connective tissue
abdomen
labor
fetuses
estimates
pulses
repetition
elastic properties
Elasticity
United States Food and Drug Administration
Abdomen
Connective Tissue
Sprague Dawley Rats

Keywords

  • Cervical softening and ripening
  • Focused ultrasound stimulation
  • Ultrasound bio-effects

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics
  • Medicine(all)

Cite this

Treatment with Focused Ultrasound Waves Softens the Rat Cervix During Pregnancy. / Luo, Daishen; Yu, Heng; Garfield, Robert E.; Shi, Shao Qing; Towe, Bruce.

In: Ultrasound in Medicine and Biology, Vol. 40, No. 9, 2014, p. 2107-2112.

Research output: Contribution to journalArticle

Luo, Daishen ; Yu, Heng ; Garfield, Robert E. ; Shi, Shao Qing ; Towe, Bruce. / Treatment with Focused Ultrasound Waves Softens the Rat Cervix During Pregnancy. In: Ultrasound in Medicine and Biology. 2014 ; Vol. 40, No. 9. pp. 2107-2112.
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