Treatment Effect Modeling for FTIR Signals Subject to Multiple Sources of Uncertainties

Hongzhen Tian, Andi Wang, Jialei Chen, Xuzhou Jiang, Jianjun Shi, Chuck Zhang, Yajun Mei, Ben Wang

Research output: Contribution to journalArticlepeer-review


Fourier-transform infrared spectroscopy (FTIR) is a widely adopted technique for characterizing the chemical composition in many physical and chemical analyses. However, FTIR spectra are subject to multiple sources of uncertainty, and thus the analysis of them relies on domain experts and can only lead to qualitative conclusions. This study aims to analyze the effect of a certain treatment on FTIR spectra subject to two commonly observed uncertainties, the offset shift and the multiplicative error. Due to these uncertainties, the pre-exposure FTIR spectra are modeled according to the physical understanding of the uncertainty--observed spectra can be viewed as translating and stretchering an underlying template signal, and the post-exposure FTIR spectra are modeled as the translated and stretchered template signal plus an extra functional treatment effect. To provide engineering interpretation, the treatment effect is modeled as the product of the pattern of modification and its corresponding magnitude. A two-step parameter estimation algorithm is developed to estimate the underlying template signal, the pattern of modification, and the magnitude of modification at various treatment strengths. The effectiveness of the proposed method is validated in a simulation study. Furtherly, in a real case study, the proposed method is used to investigate the effect of plasma exposure on the FTIR spectra. As a result, the proposed method effectively identifies the pattern of modification under uncertainties in the manufacturing environment, which matches the knowledge of the affected chemical components by the plasma treatment. And the recovered magnitude of modification provides guidance in selecting the control parameter of the plasma treatment.

Original languageEnglish (US)
JournalIEEE Transactions on Automation Science and Engineering
StateAccepted/In press - 2021
Externally publishedYes


  • Chemicals
  • Composite material
  • Fourier-transform infrared spectroscopy (FTIR)
  • Manufacturing
  • Measurement uncertainty
  • Plasma measurements
  • plasma surface treatment
  • Plasmas
  • spectral data analysis.
  • Surface treatment
  • Uncertainty

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering


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