Abstract
The PitzHugh-Nagumo equations have been used as a caricature of the Hodgkin-Huxley equations of neuron firing and to capture, qualitatively, the general properties of an excitable membrane. In this paper, we utilize a modified version of the FitzHugh-Nagumo equations to model the spatial propagation of neuron firing; we assume that this propagation is (at least, partially) caused by the cross-diffusion connection between the potential and recovery variables. We show that the cross-diffusion version of the model, besides giving rise to the typical fast traveling wave solution exhibited in the original "diffusion" FitzHugh-Nagumo equations, additionally gives rise to a slow traveling wave solution. We analyze all possible traveling wave solutions of the model and show that there exists a threshold of the cross-diffusion coefficient (for a given speed of propagation), which bounds the area where "normal" impulse propagation is possible.
Original language | English (US) |
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Pages (from-to) | 239-260 |
Number of pages | 22 |
Journal | Mathematical Biosciences and Engineering |
Volume | 5 |
Issue number | 2 |
DOIs | |
State | Published - Apr 2008 |
Keywords
- Cross-diffusion
- Fitzhugh
- Traveling wave solutions
ASJC Scopus subject areas
- Modeling and Simulation
- Agricultural and Biological Sciences(all)
- Computational Mathematics
- Applied Mathematics