Abstract
Guanidinium ions tethered to an electrode form electrical contacts to DNA via hydrogen bonding with the backbone phosphates, thus providing a sequence-independent electrical connector for native DNA submerged in an aqueous electrolyte. DNA adlayers on a guanidinium modified electrode can be imaged by scanning tunneling microscopy with tens of pS gap conductance. The image resolution suggests that multiatom contacts contribute to the tunnel conductance, so we estimate that the single-nucleotide pair conductance may be on the order of 1 pS.
Original language | English (US) |
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Pages (from-to) | 2530-2534 |
Number of pages | 5 |
Journal | Nano Letters |
Volume | 8 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2008 |
ASJC Scopus subject areas
- Bioengineering
- General Chemistry
- General Materials Science
- Condensed Matter Physics
- Mechanical Engineering