Translocation of single-stranded DNA through single-walled carbon nanotubes

Haitao Liu, Jin He, Jinyao Tang, Hao Liu, Pei Pang, Di Cao, Predrag Krstic, Sony Joseph, Stuart Lindsay, Colin Nuckolls

Research output: Contribution to journalArticle

220 Scopus citations

Abstract

We report the fabrication of devices in which one single-walled carbon nanotube spans a barrier between two fluid reservoirs, enabling direct electrical measurement of ion transport through the tube. A fraction of the tubes pass anomalously high ionic currents. Electrophoretic transport of small single-stranded DNA oligomers through these tubes is marked by large transient increases in ion current and was confirmed by polymerase chain reaction analysis. Each current pulse contains about 107 charges, an enormous amplification of the translocated charge. Carbon nanotubes simplify the construction of nanopores, permit new types of electrical measurements, and may open avenues for control of DNA translocation.

Original languageEnglish (US)
Pages (from-to)64-67
Number of pages4
JournalScience
Volume327
Issue number5961
DOIs
StatePublished - Jan 1 2010

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Cite this

Liu, H., He, J., Tang, J., Liu, H., Pang, P., Cao, D., Krstic, P., Joseph, S., Lindsay, S., & Nuckolls, C. (2010). Translocation of single-stranded DNA through single-walled carbon nanotubes. Science, 327(5961), 64-67. https://doi.org/10.1126/science.1181799