Translational studies on Cox-2 inhibitors in the prevention and treatment of colon cancer

Rajnish A. Gupta, Raymond N. DuBois

    Research output: Contribution to journalArticlepeer-review

    41 Scopus citations

    Abstract

    Inhibitors of the inducible cyclooxygenase (COX-2) have emerged as a promising new class of drugs that may be useful for the prevention of colorectal cancer. Experimental evidence to support such a claim has come from both clinical and laboratory findings that show that both selective and nonselective COX inhibitors effectively block tumor growth. Although the precise mechanism(s) by which these drugs modulate tumor growth is not known, there is evidence from colon carcinoma cell culture studies that COX-2 activity may play an important role in regulating angiogenesis and apoptosis. Recent data obtained in animal studies suggest that COX-2 inhibitors may also be useful in the treatment of established colorectal tumors. Treatment of COX-2 expressing tumor cells with selective COX-2 inhibitors appears to reset the balance between cell proliferation and cell death such that there is no increase in tumor volume.

    Original languageEnglish (US)
    Pages (from-to)196-206
    Number of pages11
    JournalAnnals of the New York Academy of Sciences
    Volume910
    DOIs
    StatePublished - 2000

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • History and Philosophy of Science

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