Abstract

The study of the behavior of ion-channels can provide significant information to detect metal ions and small organic molecules in solution. Discrimination of different analytes can be performed by extracting appropriate features from the ion-channel signals and using them for classification. In this paper, we consider features extracted from the Fourier, Wavelet and Walsh-Hadamard domain representations of the ion-channel signals. The proposed approach uses the power distribution information in the transform domains as features for discrimination. We compare the performance of all the three sets of features using support vector machines for classification of analytes and present the results. Results obtained show that the transform domain features achieve high classification rates in addition to high sensitivity and specificity rates.

Original languageEnglish (US)
Title of host publicationFinal Program and Abstract Book - 9th International Conference on Information Technology and Applications in Biomedicine, ITAB 2009
DOIs
StatePublished - 2009
Event9th International Conference on Information Technology and Applications in Biomedicine, ITAB 2009 - Larnaca, Cyprus
Duration: Nov 4 2009Nov 7 2009

Other

Other9th International Conference on Information Technology and Applications in Biomedicine, ITAB 2009
CountryCyprus
CityLarnaca
Period11/4/0911/7/09

Fingerprint

Ion Channels
Support vector machines
Ions
Information Dissemination
Metal ions
Metals
Sensitivity and Specificity
Molecules
Support Vector Machine

Keywords

  • Feature extraction
  • Fourier transforms
  • Ion-channel signals
  • Walsh-Hadamard transforms
  • Wavelet transforms

ASJC Scopus subject areas

  • Computer Science Applications
  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

Cite this

Ramamurthy, K. N., Thiagarajan, J. J., Sattigeri, P., Konnanath, B., Spanias, A., Thornton, T., ... Goodnick, S. (2009). Transform domain features for ion-channel signal classification using support vector machines. In Final Program and Abstract Book - 9th International Conference on Information Technology and Applications in Biomedicine, ITAB 2009 [5394297] https://doi.org/10.1109/ITAB.2009.5394297

Transform domain features for ion-channel signal classification using support vector machines. / Ramamurthy, Karthikeyan Natesan; Thiagarajan, Jayaraman J.; Sattigeri, Prasanna; Konnanath, Bharatan; Spanias, Andreas; Thornton, Trevor; Prasad, Shalini; Goryll, Michael; Phillips, Stephen; Goodnick, Stephen.

Final Program and Abstract Book - 9th International Conference on Information Technology and Applications in Biomedicine, ITAB 2009. 2009. 5394297.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ramamurthy, KN, Thiagarajan, JJ, Sattigeri, P, Konnanath, B, Spanias, A, Thornton, T, Prasad, S, Goryll, M, Phillips, S & Goodnick, S 2009, Transform domain features for ion-channel signal classification using support vector machines. in Final Program and Abstract Book - 9th International Conference on Information Technology and Applications in Biomedicine, ITAB 2009., 5394297, 9th International Conference on Information Technology and Applications in Biomedicine, ITAB 2009, Larnaca, Cyprus, 11/4/09. https://doi.org/10.1109/ITAB.2009.5394297
Ramamurthy KN, Thiagarajan JJ, Sattigeri P, Konnanath B, Spanias A, Thornton T et al. Transform domain features for ion-channel signal classification using support vector machines. In Final Program and Abstract Book - 9th International Conference on Information Technology and Applications in Biomedicine, ITAB 2009. 2009. 5394297 https://doi.org/10.1109/ITAB.2009.5394297
Ramamurthy, Karthikeyan Natesan ; Thiagarajan, Jayaraman J. ; Sattigeri, Prasanna ; Konnanath, Bharatan ; Spanias, Andreas ; Thornton, Trevor ; Prasad, Shalini ; Goryll, Michael ; Phillips, Stephen ; Goodnick, Stephen. / Transform domain features for ion-channel signal classification using support vector machines. Final Program and Abstract Book - 9th International Conference on Information Technology and Applications in Biomedicine, ITAB 2009. 2009.
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