Transcriptional response of avian cells to infection with Newcastle disease virus

Shirin Munir, Jagdev M. Sharma, Vivek Kapur

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Newcastle disease virus (NDV) causes widespread disease in poultry and wild-birds throughout the world. cDNA microarray analysis was used to examine the effect of NDV infection on host cell transcription. The results show that NDV infection causes an apparent suppression of the interferon response genes during the early stages of infection. In addition, the results reveal transcriptional silencing of cytoskeletal proteins such as the α, β, and γ types of actin, and a downregulation of the thioredoxin gene, a likely mediator of apoptosis with possible implications in NDV pathogenesis. Comparative analyses show that a majority of genes that were transcriptionally regulated during infection with another common respiratory pathogen of poultry, the avian pneumovirus, remained unaltered during NDV infection, suggesting that even phylogenetically related viruses elicit unique or "signature" patterns of host transcriptional profiles during infection of host cells.

Original languageEnglish (US)
Pages (from-to)103-108
Number of pages6
JournalVirus research
Volume107
Issue number1
DOIs
StatePublished - Jan 1 2005

Keywords

  • Avian pneumovirus
  • Gene expression
  • Host transcription
  • Microarray
  • Newcastle disease virus
  • Poultry
  • Respiratory infection

ASJC Scopus subject areas

  • Cancer Research
  • Virology
  • Infectious Diseases

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