TY - JOUR
T1 - Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits
AU - Tufail, Yusuf
AU - Matyushov, Alexei
AU - Baldwin, Nathan
AU - Tauchmann, Monica L.
AU - Georges, Joseph
AU - Yoshihiro, Anna
AU - Helms Tillery, Stephen
AU - Tyler, William
N1 - Funding Information:
We thank Dr. William T. Newsome of Stanford University for his critical feedback and insightful discussions regarding this manuscript. We thank Joshua Nichols, Zachary Gilbert, and Erik Handberg for their assistance in performing some of the behavioral experiments. Funding for this research was provided by start-up funds from Arizona State University to W.J.T. and a Department of Defense grant to W.J.T. from the US Army Research, Development, and Engineering Command (RDECOMW911NF-09-0431). W.J.T. is the cofounder of SynSonix.
PY - 2010/6
Y1 - 2010/6
N2 - Electromagnetic-based methods of stimulating brain activity require invasive procedures or have other limitations. Deep-brain stimulation requires surgically implanted electrodes. Transcranial magnetic stimulation does not require surgery, but suffers from low spatial resolution. Optogenetic-based approaches have unrivaled spatial precision, but require genetic manipulation. In search of a potential solution to these limitations, we began investigating the influence of transcranial pulsed ultrasound on neuronal activity in the intact mouse brain. In motor cortex, ultrasound-stimulated neuronal activity was sufficient to evoke motor behaviors. Deeper in subcortical circuits, we used targeted transcranial ultrasound to stimulate neuronal activity and synchronous oscillations in the intact hippocampus. We found that ultrasound triggers TTX-sensitive neuronal activity in the absence of a rise in brain temperature (<0.01°C). Here, we also report that transcranial pulsed ultrasound for intact brain circuit stimulation has a lateral spatial resolution of approximately 2 mm and does not require exogenous factors or surgical invasion.
AB - Electromagnetic-based methods of stimulating brain activity require invasive procedures or have other limitations. Deep-brain stimulation requires surgically implanted electrodes. Transcranial magnetic stimulation does not require surgery, but suffers from low spatial resolution. Optogenetic-based approaches have unrivaled spatial precision, but require genetic manipulation. In search of a potential solution to these limitations, we began investigating the influence of transcranial pulsed ultrasound on neuronal activity in the intact mouse brain. In motor cortex, ultrasound-stimulated neuronal activity was sufficient to evoke motor behaviors. Deeper in subcortical circuits, we used targeted transcranial ultrasound to stimulate neuronal activity and synchronous oscillations in the intact hippocampus. We found that ultrasound triggers TTX-sensitive neuronal activity in the absence of a rise in brain temperature (<0.01°C). Here, we also report that transcranial pulsed ultrasound for intact brain circuit stimulation has a lateral spatial resolution of approximately 2 mm and does not require exogenous factors or surgical invasion.
KW - Sysneuro
UR - http://www.scopus.com/inward/record.url?scp=77953668583&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953668583&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2010.05.008
DO - 10.1016/j.neuron.2010.05.008
M3 - Article
C2 - 20547127
AN - SCOPUS:77953668583
SN - 0896-6273
VL - 66
SP - 681
EP - 694
JO - Neuron
JF - Neuron
IS - 5
ER -