Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits

Yusuf Tufail, Alexei Matyushov, Nathan Baldwin, Monica L. Tauchmann, Joseph Georges, Anna Yoshihiro, Stephen Helms Tillery, William Tyler

Research output: Contribution to journalArticle

335 Citations (Scopus)

Abstract

Electromagnetic-based methods of stimulating brain activity require invasive procedures or have other limitations. Deep-brain stimulation requires surgically implanted electrodes. Transcranial magnetic stimulation does not require surgery, but suffers from low spatial resolution. Optogenetic-based approaches have unrivaled spatial precision, but require genetic manipulation. In search of a potential solution to these limitations, we began investigating the influence of transcranial pulsed ultrasound on neuronal activity in the intact mouse brain. In motor cortex, ultrasound-stimulated neuronal activity was sufficient to evoke motor behaviors. Deeper in subcortical circuits, we used targeted transcranial ultrasound to stimulate neuronal activity and synchronous oscillations in the intact hippocampus. We found that ultrasound triggers TTX-sensitive neuronal activity in the absence of a rise in brain temperature (<0.01°C). Here, we also report that transcranial pulsed ultrasound for intact brain circuit stimulation has a lateral spatial resolution of approximately 2 mm and does not require exogenous factors or surgical invasion.

Original languageEnglish (US)
Pages (from-to)681-694
Number of pages14
JournalNeuron
Volume66
Issue number5
DOIs
StatePublished - Jun 2010

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Brain
Optogenetics
Implanted Electrodes
Deep Brain Stimulation
Transcranial Magnetic Stimulation
Electromagnetic Phenomena
Motor Cortex
Hippocampus
Temperature
Ultrasonic Waves

Keywords

  • Sysneuro

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Tufail, Y., Matyushov, A., Baldwin, N., Tauchmann, M. L., Georges, J., Yoshihiro, A., ... Tyler, W. (2010). Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits. Neuron, 66(5), 681-694. https://doi.org/10.1016/j.neuron.2010.05.008

Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits. / Tufail, Yusuf; Matyushov, Alexei; Baldwin, Nathan; Tauchmann, Monica L.; Georges, Joseph; Yoshihiro, Anna; Helms Tillery, Stephen; Tyler, William.

In: Neuron, Vol. 66, No. 5, 06.2010, p. 681-694.

Research output: Contribution to journalArticle

Tufail, Y, Matyushov, A, Baldwin, N, Tauchmann, ML, Georges, J, Yoshihiro, A, Helms Tillery, S & Tyler, W 2010, 'Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits', Neuron, vol. 66, no. 5, pp. 681-694. https://doi.org/10.1016/j.neuron.2010.05.008
Tufail Y, Matyushov A, Baldwin N, Tauchmann ML, Georges J, Yoshihiro A et al. Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits. Neuron. 2010 Jun;66(5):681-694. https://doi.org/10.1016/j.neuron.2010.05.008
Tufail, Yusuf ; Matyushov, Alexei ; Baldwin, Nathan ; Tauchmann, Monica L. ; Georges, Joseph ; Yoshihiro, Anna ; Helms Tillery, Stephen ; Tyler, William. / Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits. In: Neuron. 2010 ; Vol. 66, No. 5. pp. 681-694.
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